Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACKR3 | P25106 | 10/20 | 0.63 |
| ▸ | FYN | P06241 | 2/20 | 0.44 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | KMT5A | Q9NQR1 | 1/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.36 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL627066 | 0.82 | KDM4E (0.46) | ACKR3FYNGPR119 | |
| SCHEMBL627262 | 0.81 | CCNA2 (0.48) | ACKR3FYNGPR119 | |
| SCHEMBL627015 | 0.80 | ACKR3 (0.61) | ACKR3TLR8KMT5ATGFBR1TGFBR2 | |
| SCHEMBL626544 | 0.79 | ACKR3 (0.55) | ACKR3FYN | |
| SCHEMBL627340 | 0.79 | NAMPT (0.49) | ACKR3GPR119 | |
| SCHEMBL623028 | 0.78 | ACKR3 (0.54) | ACKR3FYN | |
| SCHEMBL626662 | 0.78 | ADORA3 (0.40) | ACKR3FYN | |
| SCHEMBL625491 | 0.77 | NAMPT (0.41) | ACKR3GPR119 | |
| SCHEMBL627264 | 0.77 | CKS1B (0.43) | GPR119LMNA | |
| SCHEMBL622971 | 0.74 | ALDH1A1 (0.41) | GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012020217-A1 | AMINO- IMIDAZOLOTHIADIAZOLES FOR USE AS PROTEIN OR LIPID KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2012-02-16 | — | — | WO | disclosed |
| WO-2012020215-A1 | AMINO- IMIDAZOLOTHIADIAZOLES FOR USE AS PROTEIN OR LIPID KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2012-02-16 | — | — | WO | disclosed |