Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 1/20 | 0.37 |
| ▸ | NOS2 | P35228 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | XIAP | P98170 | 1/20 | 0.35 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.34 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 4/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.32 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.32 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.32 |
| ▸ | PLAU | P00749 | 1/20 | 0.32 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
| ▸ | CCR1 | P32246 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7369952 | 0.78 | ALDH1A1 (0.48) | ALDH1A1MAPTRAB9ACCNE2CCNE1 | |
| SCHEMBL6279299 | 0.78 | P2RX7 (0.47) | NOS3NOS2KDM4EALDH1A1RAB9A | |
| SCHEMBL5793588 | 0.76 | KMT2A (0.49) | KDM4EALDH1A1MAPTRAB9ACDK2 | |
| SCHEMBL6372981 | 0.75 | KMT2A (0.48) | NOS3NOS2KDM4EALDH1A1HSD17B10 | |
| SCHEMBL13434954 | 0.74 | MAPT (0.47) | NOS3NOS2KDM4EALDH1A1HSD17B10 | |
| SCHEMBL9832118 | 0.71 | POLB (0.51) | ALDH1A1MAPTCCNE2CCNE1CDK2 | |
| SCHEMBL22426391 | 0.69 | RAB9A (0.49) | KDM4EALDH1A1HSD17B10MAPTRAB9A | |
| SCHEMBL5821360 | 0.69 | ALDH1A1 (0.49) | KDM4EALDH1A1HSD17B10MAPTRAB9A | |
| SCHEMBL21449253 | 0.69 | GPR84 (0.59) | ALDH1A1MAPTRAB9ANPC1TP53 | |
| SCHEMBL3982930 | 0.68 | MAPT (0.52) | ALDH1A1HSD17B10MAPTCCNE2CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005108401-A1 | 2-PYRIDINYL[7-(SUBSTITUTED-PYRIDIN-4-YL) PYRAZOLO[1,5-A]PYRIMIDIN-3-YL]METHANONES | DOV PHARMACEUTICAL, INC. (US) | 2005-11-17 | — | — | WO | disclosed |
| US-20050245517-A1 | 2-pyridinyl[7-(substituted-pyridin-4-yl) pyrazolo[1,5-a]pyrimidin-3-yl]methanones | SKOLNICK PHIL | 2005-11-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050245517-A1 | 2-pyridinyl[7-(substituted-pyridin-4-yl) pyrazolo[1,5-a]pyrimidin-3-yl]methanones | HTR1A, HTR2B, HTR3B | NOS3 2602/4885NOS2 2629/4885KDM4E 3614/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.