Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 3/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | CASP3 | P42574 | 9/20 | 0.40 |
| ▸ | CASP7 | P55210 | 9/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.39 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 2/20 | 0.39 |
| ▸ | CASP6 | P55212 | 1/20 | 0.39 |
| ▸ | CDC25A | P30304 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9050379 | 0.79 | MAOB (0.55) | BCHEALDH1A1ALDH2ALDH3A1 | |
| SCHEMBL4503347 | 0.78 | MAOB (0.56) | CES1BCHECDC25A | |
| SCHEMBL6284754 | 0.77 | MAOB (0.45) | CES1BCHEALDH1A1ALDH2ALDH3A1 | |
| SCHEMBL11147994 | 0.76 | ALDH1A1 (0.62) | CES1BCHEALDH1A1MEN1POLB | |
| SCHEMBL11149802 | 0.75 | PARK7 (0.62) | CES1BCHEALDH1A1ALDH2ALDH3A1 | |
| SCHEMBL29011259 | 0.75 | ALDH3A1 (0.60) | CES1BCHEALDH1A1ALDH2ALDH3A1 | |
| SCHEMBL29011247 | 0.75 | ALDH1A1 (0.60) | CES1BCHEALDH1A1MEN1POLB | |
| SCHEMBL11147281 | 0.75 | ALDH1A1 (0.65) | CES1BCHEALDH1A1MEN1POLB | |
| SCHEMBL6284752 | 0.74 | CES1 (0.40) | CES1BCHECASP3CASP7ALDH1A1 | |
| SCHEMBL9096146 | 0.74 | DRD2 (0.55) | CASP3CASP7ALDH1A1ALDH2ALDH3A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6906090-B1 | Compositions and methods for treating mycobacterial diseases | ASTRAZENECA AB (SE) | 2005-06-14 | — | — | US | claimed |
| EP-1058548-B1 | THE USE OF ISATIN AND OXINDOLE DERIVATIVES IN THE PREPARATION OF A MEDICAMENT FOR USE IN THE TREATMENT OF MYCOBACTERIAL DISEASE | ASTRAZENECA AB (SE) | 2003-09-17 | — | — | EP | claimed |
| EP-1058548-A1 | NEW USE | AstraZeneca AB (SE) | 2000-12-13 | — | — | EP | claimed |
| WO-1999044608-A1 | NEW USE | ASTRAZENECA AB (SE) | 1999-09-10 | — | — | WO | claimed |
| US-6906090-B1 | Compositions and methods for treating mycobacterial diseases | ASTRAZENECA AB (SE) | 2005-06-14 | — | — | US | disclosed |
| EP-1058548-B1 | THE USE OF ISATIN AND OXINDOLE DERIVATIVES IN THE PREPARATION OF A MEDICAMENT FOR USE IN THE TREATMENT OF MYCOBACTERIAL DISEASE | ASTRAZENECA AB (SE) | 2003-09-17 | — | — | EP | disclosed |
| EP-1341849-A1 | POLYAMIDE MOULDING MATERIAL WITH IMPROVED PROPERTIES | EMS-Chemie AG (CH) | 2003-09-10 | — | — | EP | disclosed |
| WO-2002040591-A1 | POLYAMIDE MOULDING MATERIAL WITH IMPROVED PROPERTIES | EMS-CHEMIE AG (CH) | 2002-05-23 | — | — | WO | disclosed |
| EP-1058548-A1 | NEW USE | AstraZeneca AB (SE) | 2000-12-13 | — | — | EP | disclosed |
| WO-1999044608-A1 | NEW USE | ASTRAZENECA AB (SE) | 1999-09-10 | — | — | WO | disclosed |
| EP-0703901-A1 | 1-SUBSTITUTED ISATIN AND OXINDOLE DERIVATIVES AS INHIBITORS OF ACETYLCHOLINESTERASE | Astra Aktiebolag (SE) | 1996-04-03 | — | — | EP | disclosed |
| WO-1994029272-A1 | 1-SUBSTITUTED ISATIN AND OXINDOLE DERIVATIVES AS INHIBITORS OF ACETYLCHOLINESTERASE | ASTRA AKTIEBOLAG (SE) | 1994-12-22 | — | — | WO | disclosed |