Sugi Predict

Sugi Predict / Compounds / SCHEMBL628078

SCHEMBL628078

SCHEMBL628078

CC(C)CCNc1ccc(Nc2ccccc2)cc1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 6/20 0.53
▸ HSD17B10 Q99714 4/20 0.53
▸ ALOX12 P18054 4/20 0.53
▸ ALOX15 P16050 3/20 0.53
▸ TSHR P16473 3/20 0.53
▸ CYP3A4 P08684 3/20 0.53
▸ MAPK1 P28482 2/20 0.53
▸ HIF1A Q16665 1/20 0.53
▸ L3MBTL1 Q9Y468 4/20 0.52
▸ TDP1 Q9NUW8 2/20 0.52
▸ LMNA P02545 2/20 0.52
▸ THRB P10828 1/20 0.52
▸ RECQL P46063 1/20 0.52
▸ ATM Q13315 1/20 0.52
▸ PTGS1 P23219 1/20 0.50
▸ SLC6A2 P23975 1/20 0.50
▸ PTGS2 P35354 1/20 0.50
▸ HTR2B P41595 1/20 0.50
▸ HPGD P15428 2/20 0.49
▸ MAPT P10636 5/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1548538 0.92 ALDH1A1 (0.56) ALDH1A1HSD17B10ALOX12ALOX15TSHR
Hydrochloric Acid SCHEMBL17710410 0.90 ALDH1A1 (0.54) ALDH1A1HSD17B10ALOX12ALOX15TSHR
SCHEMBL1849087 0.89 ALDH1A1 (0.55) ALDH1A1HSD17B10ALOX12ALOX15TSHR
SCHEMBL9468140 0.86 ALDH1A1 (0.52) ALDH1A1HSD17B10ALOX12ALOX15TSHR
SCHEMBL9468217 0.86 ALDH1A1 (0.52) ALDH1A1HSD17B10ALOX12ALOX15TSHR
SCHEMBL25443755 0.85 MAPT (0.50) ALDH1A1HSD17B10ALOX12TSHRL3MBTL1
SCHEMBL1848362 0.84 ALDH1A1 (0.47) ALDH1A1HSD17B10ALOX12ALOX15TSHR
SCHEMBL19018136 0.81 ALDH1A1 (0.68) ALDH1A1HSD17B10ALOX12ALOX15TSHR
SCHEMBL2255790 0.80 ALDH1A1 (0.64) ALDH1A1HSD17B10ALOX12ALOX15TSHR
SCHEMBL809618 0.80 ALDH1A1 (0.56) ALDH1A1HSD17B10ALOX12ALOX15TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1976821-B1 DIRECT ALKYLATION OF N-ALKYL-N'-PHENYL-P-PHENYLENEDIAMINE CHEMTURA CORP (US) 2011-05-25 — — EP claimed
EP-1976821-A1 DIRECT ALKYLATION OF N-ALKYL-N'-PHENYL-P-PHENYLENEDIAMINE CHEMTURA CORPORATION (US) 2008-10-08 — — EP claimed
US-7361788-B2 Direct alkylation of N-alkyl-N′-phenyl-p-phenylenediamine CHEMTURA CORPORATION (US) 2008-04-22 — — US claimed
WO-2007087195-A1 DIRECT ALKYLATION OF N-ALKYL-N'-PHENYL-P-PHENYLENEDIAMINE CHEMTURA CORPORATION (US) 2007-08-02 — — WO claimed
US-20070173668-A1 Direct alkylation of N-alkyl-N'-phenyl-p-phenylenediamine LANXESS SOLUTIONS US INC. 2007-07-26 — — US claimed
EP-2759341-B1 METHOD FOR PREPARING P-PHENYLENEDIAMINE ANTIOXIDANT USING A SULFUR-CONTAINING PALLADIUM/CARBON CATALYST SENNICS CO LTD (CN) 2020-03-11 — — EP disclosed
EP-2420697-B1 LIQUID ENCLOSED ANTIVIBRATION DEVICE TOYO TIRE CORP (JP) 2019-06-05 — — EP disclosed
US-9248443-B2 Sulfur-containing palladium-carbon catalyst and method for preparing and using the same JIANGSU SINORGCHEM TECHNOLOGY CO., LTD. (CN) 2016-02-02 — — US disclosed
EP-2759341-A1 SULFUR-CONTAINING PALLADIUM/CARBON CATALYST, PREPARATION METHOD THEREFOR, AND METHOD FOR PREPARING P-PHENYLENEDIAMINE ANTIOXIDANT Jiangsu Sinorgchem Technology Co., Ltd. (CN) 2014-07-30 — — EP disclosed
US-20130079559-A1 SULFUR-CONTAINING PALLADIUM-CARBON CATALYST AND METHOD FOR PREPARING AND USING THE SAME JIANGSU SINORGCHEM TECHNOLOGY CO., LTD. (CN) 2013-03-28 — — US disclosed
EP-2420697-A1 LIQUID ENCLOSED ANTIVIBRATION DEVICE Toyo Tire&Rubber Co., Ltd. (JP) 2012-02-22 — — EP disclosed
EP-1976821-A1 DIRECT ALKYLATION OF N-ALKYL-N'-PHENYL-P-PHENYLENEDIAMINE CHEMTURA CORPORATION (US) 2008-10-08 — — EP disclosed
WO-2007087195-A1 DIRECT ALKYLATION OF N-ALKYL-N'-PHENYL-P-PHENYLENEDIAMINE CHEMTURA CORPORATION (US) 2007-08-02 — — WO disclosed
US-20070173668-A1 Direct alkylation of N-alkyl-N'-phenyl-p-phenylenediamine LANXESS SOLUTIONS US INC. 2007-07-26 — — US disclosed
US-5371289-A Preparation of N-substituted-N'-phenyl p-phenylenediamines THE GOODYEAR TIRE & RUBBER COMPANY (US) 1994-12-06 — — US disclosed
EP-0617004-A1 Preparation of N-substituted-N'-phenyl-P-phenylenediamines THE GOODYEAR TIRE & RUBBER COMPANY (US) 1994-09-28 — — EP disclosed
EP-0446554-B1 PREPARATION OF A N-SUBSTITUTED PHENYLENEDIAMINE THE GOODYEAR TIRE & RUBBER COMPANY (US) 1993-10-13 — — EP disclosed
US-5068439-A Chemical intermediates for dyes, drugs, agricultural products and as antoxidants or stabilizers for rubbers THE GOODYEAR TIRE & RUBBER COMPANY (US) 1991-11-26 — — US disclosed
EP-0446554-A1 Preparation of a N-substituted phenylenediamine THE GOODYEAR TIRE & RUBBER COMPANY (US) 1991-09-18 — — EP disclosed
US-4968843-A FROM 4-HYDROXYDIPHENYLAMINE; EXCELLENT YIELDS OF HIGH PURITY THE GOODYEAR TIRE & RUBBER COMPANY (US) 1990-11-06 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070173668-A1 Direct alkylation of N-alkyl-N'-phenyl-p-phenylenediamine PNMT, AAAS, PNN ALDH1A1 663/4885HSD17B10 2077/4885ALOX12 11/4885
US-20130079559-A1 SULFUR-CONTAINING PALLADIUM-CARBON CATALYST AND METHOD FOR PREPARING AND USING THE SAME SOD1, SRM, SOD3 ALDH1A1 786/4885HSD17B10 2345/4885ALOX12 1427/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.