Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Adipic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 8/20 | 0.65 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.65 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.65 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 5/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.48 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.46 |
| ▸ | PPARG | P37231 | 6/20 | 0.44 |
| ▸ | PPARD | Q03181 | 6/20 | 0.44 |
| ▸ | PPARA | Q07869 | 6/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | TLR2 | O60603 | 2/20 | 0.44 |
| ▸ | FABP4 | P15090 | 2/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.44 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.44 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sebacic Acid SCHEMBL20164089 | 0.98 | GPR84 (0.70) | GPR84FFAR1FFAR4CAMK2ALMNA | |
| Adipic Acid SCHEMBL902718 | 0.93 | GPR84 (0.54) | GPR84FFAR1FFAR4CAMK2ALMNA | |
| Adipic Acid SCHEMBL346488 | 0.93 | LMNA (0.58) | GPR84FFAR1FFAR4LMNATSHR | |
| Adipic Acid SCHEMBL27922095 | 0.93 | LMNA (0.58) | GPR84FFAR1FFAR4LMNATSHR | |
| Adipic Acid SCHEMBL10936251 | 0.93 | LMNA (0.58) | GPR84FFAR1FFAR4LMNATSHR | |
| Adipic Acid SCHEMBL28436413 | 0.91 | LMNA (0.55) | GPR84FFAR1FFAR4LMNATSHR | |
| Azelaic Acid SCHEMBL347853 | 0.91 | TSHR (0.60) | GPR84FFAR1FFAR4LMNATSHR | |
| Sebacic Acid SCHEMBL347212 | 0.91 | TSHR (0.60) | GPR84FFAR1FFAR4LMNATSHR | |
| Octanedioate SCHEMBL28872523 | 0.91 | TSHR (0.60) | GPR84FFAR1FFAR4LMNATSHR | |
| Propylene Glycol SCHEMBL5035967 | 0.91 | TSHR (0.60) | GPR84FFAR1FFAR4LMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109776734-B | Temperature-sensitive polyurethane-acrylic resin, preparation method thereof and hot melt adhesive film | 广东盈通新材料有限公司 | 2022-02-25 | — | — | CN | disclosed |
| EP-2931793-B1 | COPOLYESTERS PLASTICIZED WITH POLYMERIC PLASTICIZER FOR SHRINK FILM APPLICATIONS | EASTMAN CHEM CO (US) | 2017-01-25 | — | — | EP | disclosed |
| US-6841603-B1 | Polymer blends containing polyhydroxyalkanoates and compositions with good retention of elongation | METABOLIX, INC. (US) | 2005-01-11 | — | — | US | disclosed |
| US-6191203-B1 | BIODEGRADABLE; RECYCLABLE, COMPOSTABLE; FOR MAKING PACKING BAGS, PERSONAL HYGIENE PRODUCTS; DUCTILITY | MONSANTO COMPANY | 2001-02-20 | — | — | US | disclosed |
| EP-1027384-A2 | POLYMER BLENDS CONTAINING POLYHYDROXYALKANOATES AND COMPOSITIONS WITH GOOD RETENTION OF ELONGATION | THE MONSANTO COMPANY (US) | 2000-08-16 | — | — | EP | disclosed |
| WO-1999023161-A2 | POLYMER BLENDS CONTAINING POLYHYDROXYALKANOATES AND COMPOSITIONS WITH GOOD RETENTION OF ELONGATION | MONSANTO COMPANY (US) | 1999-05-14 | — | — | WO | disclosed |