SCHEMBL628328

SCHEMBL628328

CN1c2ccccc2Sc2ccc(Cl)cc21

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOA P21397 1/20 0.68
ITGB2 P05107 1/20 0.60
ICAM1 P05362 1/20 0.60
ITGAL P20701 1/20 0.60
LMNA P02545 4/20 0.58
MAPT P10636 4/20 0.58
TDP1 Q9NUW8 3/20 0.58
MAPK1 P28482 3/20 0.58
L3MBTL1 Q9Y468 2/20 0.58
NOX1 Q9Y5S8 2/20 0.58
CYP1A2 P05177 3/20 0.57
HTR1A P08908 3/20 0.57
CYP2D6 P10635 3/20 0.57
DRD2 P14416 3/20 0.57
CYP2C19 P33261 3/20 0.57
SMN1; SMN2 Q16637 3/20 0.57
ADRA2A P08913 3/20 0.57
ADRA2B P18089 3/20 0.57
ADRA2C P18825 3/20 0.57
CHRM3 P20309 3/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL628020 0.89 MAOA (0.68) MAOAITGB2ICAM1ITGALLMNA
SCHEMBL12626152 0.87 NOX1 (0.49) MAOAITGB2ICAM1ITGALLMNA
SCHEMBL231247 0.82 MAOA (1.00) MAOALMNAMAPTTDP1MAPK1
SCHEMBL29377505 0.82 MAOA (1.00) MAOALMNAMAPTTDP1MAPK1
SCHEMBL4708655 0.82 ITGB2 (0.46) MAOAITGB2ICAM1ITGALLMNA
SCHEMBL10923052 0.81 BCHE (0.56) ITGB2ICAM1ITGALLMNAMAPT
SCHEMBL28640004 0.80 NOX1 (0.43) MAOAITGB2ICAM1ITGALLMNA
SCHEMBL627989 0.80 MAOA (0.70) MAOALMNAMAPTTDP1MAPK1
SCHEMBL14292499 0.79 ITGB2 (0.72) ITGB2ICAM1ITGALLMNAMAPT
SCHEMBL21449095 0.79 BCHE (0.54) ITGB2ICAM1ITGALLMNAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 103 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1883987-A1 SUBSTITUTED PHENOTHIAZINE REDOX SHUTTLES FOR RECHARGEABLE LITHIUM-ION CELL 3M Innovative Properties Company (US) 2008-02-06 EP claimed
US-20060263697-A1 Substituted phenothiazine redox shuttles for rechargeable lithium-ion cell 3M INNOVATIVE PROPERTIES COMPANY 2006-11-23 US claimed
WO-2006124738-A1 SUBSTITUTED PHENOTHIAZINE REDOX SHUTTLES FOR RECHARGEABLE LITHIUM-ION CELL 3M INNOVATIVE PROPERTIES COMPANY (US) 2006-11-23 WO claimed
US-20040049859-A1 Enzyme composition for bleaching human keratinous fibres and bleaching method L'OREAL S.A. (FR) 2004-03-18 US claimed
US-20040025265-A1 Enzyme composition for bleaching human keratinous fibres and bleaching method LANG GERARD (FR) 2004-02-12 US claimed
CN-1443059-A Enzyme composition for bleaching human keratinous fibres and bleaching method OREAL (FR) 2003-09-17 CN claimed
CN-1443058-A Enzyme composition for bleaching human keratinous fibres and bleaching method OREAL (FR) 2003-09-17 CN claimed
CN-1443060-A Enzyme-based composition and process for bleaching human keratin fibers OREAL (FR) 2003-09-17 CN claimed
US-20030159706-A1 Enzyme composition for bleaching human keratinous fibres and bleaching method L'OREAL S.A. (FR) 2003-08-28 US claimed
EP-1304996-A1 ENZYME COMPOSITION FOR BLEACHING HUMAN KERATINOUS FIBRES AND BLEACHING METHOD L'OREAL (FR) 2003-05-02 EP claimed
EP-1304997-A1 ENZYME COMPOSITION FOR BLEACHING HUMAN KERATINOUS FIBRES AND BLEACHING METHOD L'OREAL (FR) 2003-05-02 EP claimed
US-20020119136-A1 Antimicrobial peroxidase compositions NOVOZYMES A/S (DK) 2002-08-29 US claimed
WO-2002007689-A1 ENZYME COMPOSITION FOR BLEACHING HUMAN KERATINOUS FIBRES AND BLEACHING METHOD L'OREAL (FR) 2002-01-31 WO claimed
WO-2002007688-A1 ENZYME COMPOSITION FOR BLEACHING HUMAN KERATINOUS FIBRES AND BLEACHING METHOD L'OREAL (FR) 2002-01-31 WO claimed
WO-2002007687-A1 ENZYME COMPOSITION FOR BLEACHING HUMAN KERATINOUS FIBRES AND BLEACHING METHOD L'OREAL (FR) 2002-01-31 WO claimed
JP-2000512267-A 2000-09-19 JP claimed
EP-0912097-A1 ANTIMICROBIAL PEROXIDASE COMPOSITIONS NOVO NORDISK A/S (DK) 1999-05-06 EP claimed
WO-1997042825-A1 ANTIMICROBIAL PEROXIDASE COMPOSITIONS NOVO NORDISK A/S (DK) 1997-11-20 WO claimed
EP-0679183-A1 ENHANCEMENT OF ENZYME REACTIONS NOVO NORDISK A/S (DK) 1995-11-02 EP claimed
WO-1994012621-A1 ENHANCEMENT OF ENZYME REACTIONS NOVO NORDISK (DK) 1994-06-09 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030159706-A1 Enzyme composition for bleaching human keratinous fibres and bleaching method KRT18, LPO, MPO MAOA 90/4885ITGB2 2634/4885ICAM1 4296/4885
US-20040025265-A1 Enzyme composition for bleaching human keratinous fibres and bleaching method KRT18, LPO, ALDH1A2 MAOA 162/4885ITGB2 3588/4885ICAM1 4823/4885
US-20040049859-A1 Enzyme composition for bleaching human keratinous fibres and bleaching method KRT18, COXFA4, LPO MAOA 108/4885ITGB2 3371/4885ICAM1 4685/4885
US-20020119136-A1 Antimicrobial peroxidase compositions LPO, MPO, GPX4 MAOA 1245/4885ITGB2 4230/4885ICAM1 1930/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.