Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | PLAU | P00749 | 1/20 | 0.44 |
| ▸ | ELANE | P08246 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CRHBP | P24387 | 1/20 | 0.43 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.43 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6698677 | 0.77 | ALDH1A1 (0.35) | HTTNPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL7905681 | 0.71 | HTT (0.71) | HTTNPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL5846730 | 0.71 | HTT (0.50) | HTTNPC1PLAUELANESMN1; SMN2 | |
| SCHEMBL17993501 | 0.70 | HTT (0.65) | HTTNPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL4162497 | 0.70 | HTT (0.65) | HTTNPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL6790765 | 0.69 | ALDH1A1 (0.52) | NPC1ALDH1A1MAPTLMNAKMT2A | |
| SCHEMBL4928502 | 0.69 | HTT (0.73) | HTTNPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL2494898 | 0.69 | HTT (0.73) | HTTNPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL6484868 | 0.69 | ALDH1A1 (0.35) | HTTNPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL7088459 | 0.68 | ALOX5 (0.41) | SMN1; SMN2ALDH1A1LMNAKMT2ACA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6852761-B2 | Polycyclic aryl and heteroaryl substituted benzenes useful for selective inhibition of the coagulation cascade | PHARMACIA CORPORATION (US) | 2005-02-08 | — | — | US | disclosed |
| US-20030236231-A1 | Polycyclic aryl and heteroaryl substituted benzenes useful for selective inhibition of the coagulation cascade | PHARMACIA CORPORATION | 2003-12-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030236231-A1 | Polycyclic aryl and heteroaryl substituted benzenes useful for selective inhibition of the coagulation cascade | TFPI, TFPI2, PLAT | HTT 1458/4885NPC1 3503/4885RAB9A 4407/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.