Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHPS | P49366 | 14/20 | 0.45 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA4 | P22748 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1748457 | 0.92 | DHPS (0.50) | DHPSNFE2L2ALDH1A1MAPK1HTT | |
| SCHEMBL7297617 | 0.81 | DHPS (0.58) | DHPSNFE2L2ALDH1A1MAPK1HTT | |
| SCHEMBL1748489 | 0.76 | L3MBTL1 (0.46) | ALDH1A1MAPK1HTTL3MBTL1MEN1 | |
| SCHEMBL618135 | 0.75 | DHPS (0.58) | DHPS | |
| SCHEMBL7303200 | 0.75 | NPBWR1 (0.48) | DHPSNFE2L2ALDH1A1MEN1KMT2A | |
| SCHEMBL29770374 | 0.75 | DHPS (0.58) | DHPS | |
| SCHEMBL7298131 | 0.75 | TRPA1 (0.45) | DHPSNFE2L2ALDH1A1MAPK1MEN1 | |
| SCHEMBL1748336 | 0.75 | SMN1; SMN2 (0.48) | NFE2L2ALDH1A1MAPK1HTTMEN1 | |
| SCHEMBL7204802 | 0.75 | DHPS (0.57) | DHPSALDH1A1MAPK1HTTL3MBTL1 | |
| SCHEMBL5632471 | 0.75 | DHPS (0.57) | DHPSALDH1A1MAPK1HTTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2419421-A1 | PROCESS FOR PREPARATION OF ENDOTHELIAL RECEPTOR ANTAGONIST (BOSENTAN) | Sandoz AG (CH) | 2012-02-22 | — | — | EP | disclosed |
| US-8080549-B2 | Endothelin receptor antagonists | CONCERT PHARMACEUTICALS, INC. (US) | 2011-12-20 | — | — | US | disclosed |
| US-8071596-B2 | Endothelin receptor antagonists | CONCERT PHARMACEUTICALS, INC. (US) | 2011-12-06 | — | — | US | disclosed |
| WO-2010118992-A1 | PROCESS FOR PREPARATION OF ENDOTHELIAL RECEPTOR ANTAGONIST (BOSENTAN) | SANDOZ AG (CH) | 2010-10-21 | — | — | WO | disclosed |
| US-20100063076-A1 | Endothelin receptor antagonists | SUN PHARMACEUTICAL INDUSTRIES, INC. | 2010-03-11 | — | — | US | disclosed |
| US-20090005394-A1 | Endothelin receptor antagonists | SUN PHARMACEUTICAL INDUSTRIES, INC. | 2009-01-01 | — | — | US | disclosed |
| WO-2008088727-A2 | ENDOTHELIN RECEPTOR ANTAGONISTS | CONCERT PHARMACEUTICALS, INC. (US) | 2008-07-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100063076-A1 | Endothelin receptor antagonists | EDNRA, EDNRB, ECE1 | DHPS 2603/4885NFE2L2 846/4885ALDH1A1 3474/4885 |
| US-20090005394-A1 | Endothelin receptor antagonists | EDNRA, EDNRB, ECE1 | DHPS 3146/4885NFE2L2 1042/4885ALDH1A1 3953/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.