Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 2/20 | 0.52 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.45 |
| ▸ | GPR84 | Q9NQS5 | 8/20 | 0.44 |
| ▸ | PPARG | P37231 | 6/20 | 0.43 |
| ▸ | PPARD | Q03181 | 6/20 | 0.43 |
| ▸ | PPARA | Q07869 | 6/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.43 |
| ▸ | TSHR | P16473 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | TLR2 | O60603 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | FABP4 | P15090 | 2/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.43 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.43 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinic Acid SCHEMBL899288 | 0.90 | CA2 (0.61) | CA2CA1NFKB1GPR84FABP3 | |
| Butyric Acid SCHEMBL10765538 | 0.84 | FFAR3 (0.64) | CA2CA1NFKB1GPR84FABP3 | |
| SCHEMBL253165 | 0.82 | CA1 (0.60) | CA2CA1NFKB1GPR84FABP3 | |
| Succinic Acid SCHEMBL17839040 | 0.82 | DNM1 (0.58) | CA2CA1NFKB1GPR84FABP3 | |
| Hexanoate SCHEMBL28546350 | 0.82 | CA1 (0.60) | CA2CA1NFKB1GPR84FABP3 | |
| Bicarbonate SCHEMBL5275078 | 0.81 | DNM1 (0.55) | CA2CA1NFKB1GPR84TSHR | |
| Decanoic Acid SCHEMBL3323693 | 0.80 | FABP3 (0.60) | CA2CA1NFKB1GPR84FABP3 | |
| Dodecanoate SCHEMBL230531 | 0.80 | FABP3 (0.60) | CA2CA1NFKB1GPR84FABP3 | |
| Myristic Acid SCHEMBL15091865 | 0.80 | FABP3 (0.60) | CA2CA1NFKB1GPR84FABP3 | |
| Stearic Acid SCHEMBL9063410 | 0.80 | FABP3 (0.60) | CA2CA1NFKB1GPR84FABP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6927253-B2 | Transparent coating powder dispersions transparent coating powder slurry, method for the production and use thereof | BASF COATINGS AG (DE) | 2005-08-09 | — | — | US | disclosed |
| US-20030158332-A1 | Transparent coating powder dispersions (transparent coating powder slurry, method for the production and use thereof | BASF COATINGS AKTIENGESELLSCHAFT (DE) | 2003-08-21 | — | — | US | disclosed |