Sugi Predict

Sugi Predict / Compounds / SCHEMBL628626

SCHEMBL628626

SCHEMBL628626

Nc1ccc(-c2ncccn2)cc1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KMT2A Q03164 7/20 0.62
▸ MEN1 O00255 6/20 0.62
▸ RAB9A P51151 5/20 0.62
▸ ALDH1A1 P00352 4/20 0.62
▸ MAPT P10636 4/20 0.62
▸ NPC1 O15118 4/20 0.62
▸ HPGD P15428 3/20 0.62
▸ TP53 P04637 2/20 0.62
▸ HSD17B10 Q99714 2/20 0.62
▸ KDM4E B2RXH2 2/20 0.62
▸ SMN1; SMN2 Q16637 1/20 0.62
▸ ADRB2 P07550 1/20 0.58
▸ CLK4 Q9HAZ1 1/20 0.52
▸ CYP3A4 P08684 2/20 0.50
▸ TDP1 Q9NUW8 2/20 0.50
▸ TAAR1 Q96RJ0 1/20 0.48
▸ APAF1 O14727 1/20 0.46
▸ CYP2A6 P11509 1/20 0.44
▸ PIK3CD O00329 1/20 0.44
▸ PIP5K1C O60331 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13978027 0.86 RAB9A (0.48) KMT2AMEN1RAB9AALDH1A1MAPT
SCHEMBL6685962 0.86 CLK4 (0.64) KMT2AMEN1RAB9AALDH1A1MAPT
SCHEMBL16625771 0.83 CLK4 (0.61) KMT2AMEN1RAB9AALDH1A1MAPT
SCHEMBL27934175 0.80 HSD17B10 (0.44) KMT2AMEN1RAB9AALDH1A1MAPT
SCHEMBL12280797 0.79 RAB9A (0.77) KMT2AMEN1RAB9AALDH1A1MAPT
SCHEMBL1110568 0.78 ALDH1A1 (0.50) KMT2AMEN1RAB9AALDH1A1MAPT
SCHEMBL8425035 0.77 MEN1 (0.62) KMT2AMEN1RAB9AALDH1A1MAPT
SCHEMBL19742855 0.77 RAB9A (1.00) KMT2AMEN1RAB9AALDH1A1MAPT
SCHEMBL6565672 0.77 MEN1 (0.60) KMT2AMEN1RAB9AALDH1A1MAPT
SCHEMBL19009569 0.77 L3MBTL1 (0.56) KMT2AMEN1RAB9AALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 158 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114761452-B Method for preparing hollow covalent organic framework material 浙江大学 2024-04-09 — — CN claimed
CN-117753387-A Covalent organic framework nanocapsule material and emulsion acceleration polymerization method thereof 浙江大学 2024-03-26 — — CN claimed
CN-117229506-B Polyamic acid, polyimide film and preparation method 山东华夏神舟新材料有限公司 2024-03-15 — — CN claimed
CN-117229506-A Polyamic acid, polyimide film and preparation method 山东华夏神舟新材料有限公司 2023-12-15 — — CN claimed
CN-114761452-A Method for preparing hollow covalent organic framework material 浙江大学 2022-07-15 — — CN claimed
CN-113004532-A Metamaterial based on covalent organic framework and application of metamaterial in optical device 浙江大学 2021-06-22 — — CN claimed
CN-110172168-A A kind of aminated carbon nano tube/polyimide composite film and preparation method thereof 长安大学 2019-08-27 — — CN claimed
CN-109929129-A A kind of carboxylic carbon nano-tube/polyimide composite film and preparation method thereof 长安大学 2019-06-25 — — CN claimed
CN-103305961-B A kind of preparation method of polyimides-carbon nano tube composite fibre 中国科学院长春应用化学研究所 2016-07-06 — — CN claimed
CN-101857979-B Aramid fibers containing pyrimidine structure and preparation method thereof SINOSELEN HI TECH CO LTD 2012-07-04 — — CN claimed
CN-101857979-A Aramid fibers containing pyrimidine structure and preparation method thereof SINOSELEN HI TECH CO LTD 2010-10-13 — — CN claimed
EP-4734979-A2 TMEM175 AGONISTS, COMPOSITIONS, AND METHODS OF USE Caraway Therapeutics, Inc. (US) 2026-05-06 — — EP disclosed
US-12590071-B2 Hydrazone derivative in which terminal amine group is substituted with aryl group or heteroaryl group, and use thereof KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) 2026-03-31 — — US disclosed
US-12559495-B2 Purine diones as Wnt pathway modulators AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) 2026-02-24 — — US disclosed
EP-4695236-A1 SUBSTITUTED PHENYL-PIPERAZINYL BASED MODULATORS FOR THE TREATMENT OF DISEASE Soley Therapeutics, Inc. (US) 2026-02-18 — — EP disclosed
US-20040043987-A1 Novel compounds and their use as positive AMPA receptor modulators NEUROSEARCH A/S. 2004-03-04 — — US disclosed
EP-1071426-A2 NOVEL COMPOUNDS AND THEIR USE AS POSITIVE AMPA RECEPTOR MODULATORS NEUROSEARCH A/S (DK) 2001-01-31 — — EP disclosed
EP-1056771-A1 STREPTOGRAMIN DERIVATIVES, PREPARATION METHOD AND COMPOSITIONS CONTAINING SAME Aventis Pharma S.A. (FR) 2000-12-06 — — EP disclosed
WO-1999043699-A1 STREPTOGRAMIN DERIVATIVES, PREPARATION METHOD AND COMPOSITIONS CONTAINING SAME AVENTIS PHARMA S.A. (FR) 1999-09-02 — — WO disclosed
WO-1999042456-A2 NOVEL COMPOUNDS AND THEIR USE AS POSITIVE AMPA RECEPTOR MODULATORS NEUROSEARCH A/S (DK) 1999-08-26 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040043987-A1 Novel compounds and their use as positive AMPA receptor modulators GRIK4, GRIA4, GRM2 KMT2A 869/4885MEN1 4649/4885RAB9A 3042/4885
US-12590071-B2 Hydrazone derivative in which terminal amine group is substituted with aryl group or heteroaryl group, and use thereof ABL1, TH, CYP3A43 KMT2A 1604/4885MEN1 1574/4885RAB9A 1131/4885
US-12559495-B2 Purine diones as Wnt pathway modulators WNT1, CTNND1, WNT3A KMT2A 2932/4885MEN1 3612/4885RAB9A 1588/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.