Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | MEN1 | O00255 | 5/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 5/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3175667 | 0.82 | ALDH1A1 (0.51) | ALDH1A1MEN1KMT2AKDM4EMAPT | |
| SCHEMBL3175654 | 0.81 | NPC1 (0.56) | ALDH1A1MEN1KMT2AKDM4EMAPT | |
| SCHEMBL28093168 | 0.76 | RAB9A (0.71) | ALDH1A1MEN1KMT2AKDM4EMAPT | |
| SCHEMBL6856233 | 0.74 | NPC1 (0.58) | ALDH1A1MEN1KMT2AKDM4EMAPT | |
| SCHEMBL12327906 | 0.74 | ALDH1A1 (0.52) | ALDH1A1MEN1KMT2AKDM4EMAPT | |
| SCHEMBL128781 | 0.74 | CA1 (0.61) | ALDH1A1MEN1KMT2AKDM4EMAPT | |
| SCHEMBL312754 | 0.74 | ALDH1A1 (0.72) | ALDH1A1MEN1KMT2AKDM4EMAPT | |
| SCHEMBL29431885 | 0.74 | CA1 (0.61) | ALDH1A1MEN1KMT2AKDM4EMAPT | |
| SCHEMBL29445806 | 0.74 | ALDH1A1 (0.72) | ALDH1A1MEN1KMT2AKDM4EMAPT | |
| SCHEMBL17089323 | 0.74 | ALDH1A1 (0.52) | ALDH1A1MEN1KMT2AKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8933129-B2 | Compounds and methods for modulating activity of calcium release channels | STATE OF OREGON BY AND THROUGH THE STATE BOARD OF HIGHER EDUCATION ON BEHALF OF PORTLAND STATE UNIVERSITY (US) | 2015-01-13 | — | — | US | disclosed |
| US-20120101085-A1 | Compounds And Methods For Modulating Activity Of Calcium Release Channels | State of Oregon by and through the State Board of Higher Education on behalf of Portland State Univ. (US) | 2012-04-26 | — | — | US | disclosed |
| EP-2418950-A1 | COMPOUNDS AND METHODS FOR MODULATING ACTIVITY OF CALCIUM RELEASE CHANNELS | State Of Oregon By&Through The State Board Of Higher Education On Behalf Of Portland State Unv. (US) | 2012-02-22 | — | — | EP | disclosed |
| WO-2010120382-A1 | COMPOUNDS AND METHODS FOR MODULATING ACTIVITY OF CALCIUM RELEASE CHANNELS | STATE OF OREGON BY AND THROUGH THE STATE BOARD OF HIGHER EDUCATION ON BEHALF OF PORTLAND STATE UNIVERSITY (US) | 2010-10-21 | — | — | WO | disclosed |
| US-4539412-A | ANTITUMOR AGENTS | RENSSELAER POLYTECHNIC INSTITUTE (US) | 1985-09-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120101085-A1 | Compounds And Methods For Modulating Activity Of Calcium Release Channels | RYR2, RYR1, CACNA1E | ALDH1A1 2115/4885MEN1 3019/4885KMT2A 4517/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.