Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.51 |
| ▸ | MEN1 | O00255 | 6/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.51 |
| ▸ | HPGD | P15428 | 6/20 | 0.51 |
| ▸ | RAB9A | P51151 | 5/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.51 |
| ▸ | NPC1 | O15118 | 4/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10372128 | 0.84 | NPC1 (0.63) | ALDH1A1MEN1KMT2AHPGDRAB9A | |
| SCHEMBL628634 | 0.82 | ALDH1A1 (0.48) | ALDH1A1MEN1KMT2AHPGDRAB9A | |
| SCHEMBL11201622 | 0.82 | NPC1 (0.61) | ALDH1A1MEN1KMT2AHPGDRAB9A | |
| SCHEMBL29431885 | 0.80 | CA1 (0.61) | ALDH1A1MEN1KMT2AHPGDRAB9A | |
| SCHEMBL6575931 | 0.80 | MAPT (0.58) | ALDH1A1MEN1KMT2AHPGDKDM4E | |
| SCHEMBL128781 | 0.80 | CA1 (0.61) | ALDH1A1MEN1KMT2AHPGDRAB9A | |
| SCHEMBL865333 | 0.78 | SMN1; SMN2 (0.59) | ALDH1A1MEN1KMT2AHPGDRAB9A | |
| SCHEMBL28093168 | 0.78 | RAB9A (0.71) | ALDH1A1MEN1KMT2AHPGDRAB9A | |
| SCHEMBL6715407 | 0.76 | CA12 (0.60) | ALDH1A1MEN1KMT2AKDM4ELMNA | |
| SCHEMBL6856233 | 0.76 | NPC1 (0.58) | ALDH1A1MEN1KMT2AHPGDRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4539412-A | ANTITUMOR AGENTS | RENSSELAER POLYTECHNIC INSTITUTE (US) | 1985-09-03 | — | — | US | claimed |
| US-7671195-B2 | Process for preparing dibenzothiazepine compounds | ASTRAZENECA UK LIMITED (GB) | 2010-03-02 | — | — | US | disclosed |
| EP-1996568-A2 | PROCESS FOR PREPARING DIBENZOTHIAZEPINE COMPOUNDS | AstraZeneca UK Limited (GB) | 2008-12-03 | — | — | EP | disclosed |
| US-7314930-B2 | Process for preparing dibenzothiazepine derivatives | UBE INDUSTRIES, LTD. (JP) | 2008-01-01 | — | — | US | disclosed |
| WO-2007102352-A2 | PROCESS FOR PREPARING DIBENZOTHIAZEPINE COMPOUNDS | ASTRAZENECA UK LIMITED (GB) | 2007-09-13 | — | — | WO | disclosed |
| US-20070203336-A1 | Process for preparing dibenzothiazepine compounds | ASTRAZENECA UK LIMITED (GB) | 2007-08-30 | — | — | US | disclosed |
| US-20060173178-A1 | Process for preparing dibenzothiazepine derivatives | UBE INDUSTRIES, LTD. (JP) | 2006-08-03 | — | — | US | disclosed |
| US-7045621-B1 | Process for producing dibenzothiazepine derivatives | UBE INDUSTRIES, LTD. (JP) | 2006-05-16 | — | — | US | disclosed |
| EP-1201663-A1 | PROCESS FOR PRODUCING DIBENZOTHIAZEPINE DERIVATIVES | Ube Industries, Ltd. (JP) | 2002-05-02 | — | — | EP | disclosed |
| EP-0187487-B1 | BENZOTHIOPHENES AND BENZOFURANS HAVING ANTIALLERGIC ACTIVITY | WARNER-LAMBERT COMPANY (US) | 1990-08-29 | — | — | EP | disclosed |
| US-4703053-A | Benzothiophenes and benzofurans and antiallergic use thereof | WARNER-LAMBERT COMPANY (US) | 1987-10-27 | — | — | US | disclosed |
| EP-0187487-A1 | Benzothiophenes and benzofurans having antiallergic activity | WARNER-LAMBERT COMPANY (US) | 1986-07-16 | — | — | EP | disclosed |
| US-4539412-A | ANTITUMOR AGENTS | RENSSELAER POLYTECHNIC INSTITUTE (US) | 1985-09-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060173178-A1 | Process for preparing dibenzothiazepine derivatives | TPMT, BBOX1, NISCH | ALDH1A1 552/4885MEN1 4480/4885KMT2A 3313/4885 |
| US-20070203336-A1 | Process for preparing dibenzothiazepine compounds | TST, ADH1C, ADH5 | ALDH1A1 432/4885MEN1 4595/4885KMT2A 2658/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.