Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.56 |
| ▸ | RAB9A | P51151 | 4/20 | 0.56 |
| ▸ | HPGD | P15428 | 5/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 5/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.54 |
| ▸ | MAPT | P10636 | 5/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.54 |
| ▸ | TP53 | P04637 | 2/20 | 0.54 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.53 |
| ▸ | PGR | P06401 | 2/20 | 0.53 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10372127 | 0.85 | NPC1 (0.72) | NPC1RAB9AHPGDALDH1A1MAPK1 | |
| SCHEMBL28093168 | 0.84 | RAB9A (0.71) | NPC1RAB9AHPGDALDH1A1MAPK1 | |
| SCHEMBL312754 | 0.82 | ALDH1A1 (0.72) | NPC1RAB9AHPGDALDH1A1MAPK1 | |
| SCHEMBL29445806 | 0.82 | ALDH1A1 (0.72) | NPC1RAB9AHPGDALDH1A1MAPK1 | |
| SCHEMBL6856233 | 0.82 | NPC1 (0.58) | NPC1RAB9AHPGDALDH1A1MAPK1 | |
| SCHEMBL128781 | 0.82 | CA1 (0.61) | NPC1RAB9AHPGDALDH1A1MAPK1 | |
| SCHEMBL29431885 | 0.82 | CA1 (0.61) | NPC1RAB9AHPGDALDH1A1MAPK1 | |
| SCHEMBL6575927 | 0.81 | MAPT (0.66) | NPC1RAB9AHPGDALDH1A1MEN1 | |
| SCHEMBL551750 | 0.81 | NPC1 (0.56) | NPC1RAB9AHPGDALDH1A1MAPK1 | |
| SCHEMBL865333 | 0.81 | SMN1; SMN2 (0.59) | NPC1RAB9AHPGDALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4539412-A | ANTITUMOR AGENTS | RENSSELAER POLYTECHNIC INSTITUTE (US) | 1985-09-03 | — | — | US | claimed |
| US-7671195-B2 | Process for preparing dibenzothiazepine compounds | ASTRAZENECA UK LIMITED (GB) | 2010-03-02 | — | — | US | disclosed |
| EP-1996568-A2 | PROCESS FOR PREPARING DIBENZOTHIAZEPINE COMPOUNDS | AstraZeneca UK Limited (GB) | 2008-12-03 | — | — | EP | disclosed |
| US-7314930-B2 | Process for preparing dibenzothiazepine derivatives | UBE INDUSTRIES, LTD. (JP) | 2008-01-01 | — | — | US | disclosed |
| WO-2007102352-A2 | PROCESS FOR PREPARING DIBENZOTHIAZEPINE COMPOUNDS | ASTRAZENECA UK LIMITED (GB) | 2007-09-13 | — | — | WO | disclosed |
| US-20070203336-A1 | Process for preparing dibenzothiazepine compounds | ASTRAZENECA UK LIMITED (GB) | 2007-08-30 | — | — | US | disclosed |
| US-20060173178-A1 | Process for preparing dibenzothiazepine derivatives | UBE INDUSTRIES, LTD. (JP) | 2006-08-03 | — | — | US | disclosed |
| US-7045621-B1 | Process for producing dibenzothiazepine derivatives | UBE INDUSTRIES, LTD. (JP) | 2006-05-16 | — | — | US | disclosed |
| EP-1201663-A1 | PROCESS FOR PRODUCING DIBENZOTHIAZEPINE DERIVATIVES | Ube Industries, Ltd. (JP) | 2002-05-02 | — | — | EP | disclosed |
| EP-0187487-B1 | BENZOTHIOPHENES AND BENZOFURANS HAVING ANTIALLERGIC ACTIVITY | WARNER-LAMBERT COMPANY (US) | 1990-08-29 | — | — | EP | disclosed |
| US-4703053-A | Benzothiophenes and benzofurans and antiallergic use thereof | WARNER-LAMBERT COMPANY (US) | 1987-10-27 | — | — | US | disclosed |
| EP-0187487-A1 | Benzothiophenes and benzofurans having antiallergic activity | WARNER-LAMBERT COMPANY (US) | 1986-07-16 | — | — | EP | disclosed |
| US-4539412-A | ANTITUMOR AGENTS | RENSSELAER POLYTECHNIC INSTITUTE (US) | 1985-09-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060173178-A1 | Process for preparing dibenzothiazepine derivatives | TPMT, BBOX1, NISCH | NPC1 2677/4885RAB9A 3597/4885HPGD 78/4885 |
| US-20070203336-A1 | Process for preparing dibenzothiazepine compounds | TST, ADH1C, ADH5 | NPC1 4278/4885RAB9A 4497/4885HPGD 510/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.