Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 7/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 7/20 | 0.43 |
| ▸ | DCTPP1 | Q9H773 | 3/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 4/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 4/20 | 0.36 |
| ▸ | GABRA3 | P34903 | 4/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6297254 | 0.84 | PDE2A (0.36) | PDE2APDE10AHSD11B1GABRG2GABRB3 | |
| SCHEMBL6292716 | 0.77 | HSD17B10 (0.41) | POLB | |
| SCHEMBL5231248 | 0.75 | DCTPP1 (0.41) | DCTPP1HSD11B1GABRG2GABRB3GABRA3 | |
| SCHEMBL6297146 | 0.72 | DCTPP1 (0.41) | PDE2APDE10ADCTPP1HSD11B1POLB | |
| SCHEMBL5228914 | 0.67 | GABRG2 (0.44) | DCTPP1GABRG2GABRB3GABRA3 | |
| SCHEMBL5228723 | 0.67 | GABRG2 (0.44) | DCTPP1GABRG2GABRB3GABRA3 | |
| SCHEMBL9691130 | 0.65 | HSD11B1 (0.43) | PDE2APDE10ADCTPP1HSD11B1POLB | |
| SCHEMBL6519834 | 0.63 | HSD11B1 (0.44) | PDE2APDE10ADCTPP1HSD11B1POLB | |
| SCHEMBL14077015 | 0.63 | HSD11B1 (0.58) | PDE2APDE10ADCTPP1HSD11B1POLB | |
| SCHEMBL9690834 | 0.63 | PDE2A (0.46) | PDE2APDE10ADCTPP1HSD11B1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6872720-B2 | Pyrazolo-triazine derivatives as ligands for gaba receptors | MERCK SHARP & DOHME LTD. | 2005-03-29 | — | — | US | disclosed |
| US-20030060467-A1 | Pyrazolo-triazine derivatives as ligands for gaba receptors | MERCK SHARP & DOHME LTD. (GB) | 2003-03-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030060467-A1 | Pyrazolo-triazine derivatives as ligands for gaba receptors | GABRA5, GABRA3, GABRA4 | PDE2A 1468/4885PDE10A 1597/4885DCTPP1 4745/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.