Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | CCR5 | P51681 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.40 |
| ▸ | GABBR1 | Q9UBS5 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.37 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15868611 | 0.81 | MAPT (0.44) | LMNACCR5MAPTGABBR2GABBR1 | |
| SCHEMBL28053820 | 0.78 | LMNA (0.40) | LMNACCR5MAPTGABBR2GABBR1 | |
| SCHEMBL214563 | 0.74 | LMNA (0.47) | LMNACCR5MAPTGABBR2GABBR1 | |
| SCHEMBL1616269 | 0.73 | MAPT (0.44) | LMNAMAPTPOLBMEN1KMT2A | |
| SCHEMBL13137019 | 0.73 | MAPT (0.44) | LMNACCR5MAPTGABBR2GABBR1 | |
| SCHEMBL12082215 | 0.73 | APAF1 (0.42) | LMNACCR5MAPTGABBR2GABBR1 | |
| SCHEMBL6238050 | 0.73 | LMNA (0.45) | LMNACCR5MAPTGABBR2GABBR1 | |
| SCHEMBL15957862 | 0.73 | HDAC8 (0.44) | CCR5MAPTRIPK1CYP2D6HSD17B10 | |
| SCHEMBL5961369 | 0.72 | PIN1 (0.46) | LMNAMAPTPOLBMEN1KMT2A | |
| SCHEMBL169508 | 0.72 | LMNA (0.56) | LMNACCR5CYP2D6HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6864383-B2 | Potassium channel moderators | MERCK & CO., INC. (US) | 2005-03-08 | — | — | US | disclosed |
| US-20040054213-A1 | Using potassium channel moderators | MERCK SHARP & DOHME CORP. | 2004-03-18 | — | — | US | disclosed |
| EP-0361365-A1 | Aminobenzoic and aminocyclohexane-carboylic acid compounds, compositions, and their method of use | E.R. SQUIBB & SONS, INC. (US) | 1990-04-04 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040054213-A1 | Using potassium channel moderators | KCNN1, KCNN3, KCNJ2 | LMNA 661/4885CCR5 4461/4885MAPT 1769/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.