Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 2/20 | 0.47 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.47 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 6/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.32 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.32 |
| ▸ | PTGIR | P43119 | 2/20 | 0.32 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.32 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.32 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | MAOA | P21397 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9843775 | 0.83 | MAOB (0.44) | LOXL2MAOBSMN1; SMN2TBXA2RPTGIR | |
| SCHEMBL9843997 | 0.83 | LOXL2 (0.35) | GABRA1GABRB2LOXL2MAOB | |
| SCHEMBL21455346 | 0.81 | LOXL2 (0.44) | LOXL2MAOBCA2 | |
| SCHEMBL23115218 | 0.79 | PKM (0.46) | TP53MAOBSMN1; SMN2MEN1KMT2A | |
| SCHEMBL17321025 | 0.78 | CA2 (0.35) | GABRA1GABRB2LOXL2CA2TBXA2R | |
| SCHEMBL13298379 | 0.77 | CYP17A1 (0.40) | MAOBPSMB8PSMB5MEN1KMT2A | |
| SCHEMBL31534803 | 0.77 | LOXL2 (0.32) | LOXL2MAOBTBXA2RPTGIR | |
| SCHEMBL5544888 | 0.77 | LOXL2 (0.33) | LOXL2MAOBTBXA2RPTGIR | |
| SCHEMBL25824617 | 0.76 | LOXL2 (0.36) | LOXL2MAOB | |
| SCHEMBL806348 | 0.75 | ALDH1A1 (0.54) | CA2TBXA2RPTGIRPSMB8PSMB5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6967201-B1 | for increasing activation of the 5-HT2C receptor in mammals; treatment of depression, obesity, bulimia, premenstrual syndrome, alcoholism, tobacco abuse, panic disorder | ELI LILLY AND COMPANY (US) | 2005-11-22 | — | — | US | disclosed |
| EP-1204654-B1 | BENZOFURYLPIPERAZINES: 5-HT2C SEROTONIN RECEPTOR AGONISTS | LILLY CO ELI (US) | 2003-07-23 | — | — | EP | disclosed |
| EP-1204654-A1 | BENZOFURYLPIPERAZINES AND BENZOFURYLHOMOPIPERAZINES: SEROTONIN AGONISTS | ELI LILLY AND COMPANY (US) | 2002-05-15 | — | — | EP | disclosed |
| WO-2001009111-A1 | BENZOFURYLPIPERAZINES AND BENZOFURYLHOMOPIPERAZINES: SEROTONIN AGONISTS | ELI LILLY AND COMPANY (US) | 2001-02-08 | — | — | WO | disclosed |