Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.38 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.37 |
| ▸ | HTR2A | P28223 | 2/20 | 0.36 |
| ▸ | HTR2C | P28335 | 2/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.35 |
| ▸ | F2RL1 | P55085 | 2/20 | 0.34 |
| ▸ | KCNN4 | O15554 | 3/20 | 0.33 |
| ▸ | KCNA3 | P22001 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.33 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL706070 | 0.88 | CYP19A1 (0.48) | CYP19A1KMT2AADRA1AADRA2AADRA2C | |
| SCHEMBL698787 | 0.87 | CYP19A1 (0.43) | CYP19A1KMT2AADRA1AADRA2AADRA2C | |
| SCHEMBL697775 | 0.84 | TAAR1 (0.44) | CYP19A1KMT2ATAAR1CYP3A4MEN1 | |
| SCHEMBL698375 | 0.83 | CYP19A1 (0.40) | CYP19A1KMT2AADRA1AADRA2AADRA2C | |
| SCHEMBL27733481 | 0.82 | TAAR1 (0.43) | CYP19A1KMT2AADRA1AADRA2AADRA2C | |
| SCHEMBL7914818 | 0.82 | CYP19A1 (0.51) | CYP19A1KMT2ATAAR1CYP3A4MEN1 | |
| SCHEMBL697512 | 0.82 | CYP19A1 (0.51) | CYP19A1KMT2ATAAR1CYP3A4MEN1 | |
| SCHEMBL696482 | 0.82 | CYP19A1 (0.44) | CYP19A1KMT2AADRA1AADRA2AADRA2C | |
| SCHEMBL697816 | 0.82 | CYP19A1 (0.51) | CYP19A1KMT2ATAAR1CYP3A4MEN1 | |
| SCHEMBL1573181 | 0.81 | CYP19A1 (0.40) | CYP19A1TAAR1OPRK1KCNH2F2RL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6943183-B2 | 5-substituted tetralones as inhibitors of ras farnesyl transferase | PFIZER INC (US) | 2005-09-13 | — | — | US | disclosed |
| US-20040044057-A1 | 5- substituted tetralones as inhibitors of ras farnesyl trransferase | WARNER-LAMBERT COMPANY | 2004-03-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040044057-A1 | 5- substituted tetralones as inhibitors of ras farnesyl trransferase | PTAR1, FNTA, GGPS1 | CYP19A1 962/4885KMT2A 3889/4885ADRA1A 1431/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.