Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8652754 | 0.95 | — | — | |
| Hydrochloric Acid SCHEMBL9231643 | 0.81 | — | — | |
| Hydrochloric Acid SCHEMBL9229955 | 0.80 | — | — | |
| Hydrochloric Acid SCHEMBL9231715 | 0.80 | — | — | |
| Hydrochloric Acid SCHEMBL9232040 | 0.80 | NPC1 (0.31) | — | |
| Hydrochloric Acid SCHEMBL9229934 | 0.77 | LMNA (0.33) | — | |
| Hydrochloric Acid SCHEMBL7938762 | 0.76 | MEN1 (0.33) | — | |
| SCHEMBL9230171 | 0.76 | ALDH1A1 (0.33) | — | |
| SCHEMBL1453000 | 0.76 | PGR (0.31) | — | |
| Hydrochloric Acid SCHEMBL6560403 | 0.76 | GPR3 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6852660-B2 | Solid metallocene catalyst system | CHEVRON PHILLIPS CHEMICAL COMPANY, LP (US) | 2005-02-08 | — | — | US | claimed |
| US-20030144436-A1 | Coorination catalyst for polyalpha-olefins | MITCHELL KENT E (US) | 2003-07-31 | — | — | US | claimed |
| EP-0685495-B1 | Method for using a supported metallocene catalyst system | PHILLIPS PETROLEUM CO (US) | 1998-04-08 | — | — | EP | claimed |
| US-20050171305-A1 | Solid metallocene catalyst system | MITCHELL KENT E (US) | 2005-08-04 | — | — | US | disclosed |
| US-6852660-B2 | Solid metallocene catalyst system | CHEVRON PHILLIPS CHEMICAL COMPANY, LP (US) | 2005-02-08 | — | — | US | disclosed |
| US-6746981-B2 | OLEFIN POLYMERIZATION CATALYSTS WITH PRODUCTIVITY WHEN FRESH OF >/= 18,000 GRAMS OF POLYETHYLENE PER GRAM OF CATALYST IN ONE HOUR, AND A SPECIFIC SURFACE AREA OF </= 20 M2/G | ALBEMARLE CORPORATION | 2004-06-08 | — | — | US | disclosed |
| US-20030144436-A1 | Coorination catalyst for polyalpha-olefins | MITCHELL KENT E (US) | 2003-07-31 | — | — | US | disclosed |
| US-20030105253-A1 | Particulate group 4 metallocene-aluminoxane catalyst compositions devoid of preformed support, and their preparation and their use | ALBEMARLE CORPORATION | 2003-06-05 | — | — | US | disclosed |
| US-6534609-B2 | Making by combining an organoaluminoxane and a metallocene having olefinic unsaturated substituent(s) in an aliphatic liquid, prepolymerizing olefin(s) to produce a prepolymerized solid catalyst and separating from the liquid | CHEVRON PHILLIPS CHEMICAL COMPANY LP | 2003-03-18 | — | — | US | disclosed |
| US-6521728-B1 | Particulate group 4 metallocene-aluminoxane catalyst compositions devoid of preformed support, and their preparation and their use | ALBEMARLE CORPORATION | 2003-02-18 | — | — | US | disclosed |
| US-20020177676-A1 | Method for making and using a metallocene catalyst system | CHEVRON PHILLIPS CHEMICAL COMPANY LP, A DELAWARE LIMITED PARTNERSHIP | 2002-11-28 | — | — | US | disclosed |
| US-6166152-A | Process to produce low density polymer in a loop reactor | PHILLIPS PETROLEUM COMPANY (US) | 2000-12-26 | — | — | US | disclosed |
| EP-0810234-B1 | Method for making and using a supported metallocene catalyst system | PHILLIPS PETROLEUM CO (US) | 2000-02-16 | — | — | EP | disclosed |
| WO-1999043724-A1 | METHOD FOR POLYMERIZING MONOMERS TO PRODUCE LINEAR, LOW DENSITY POLYMER | PHILLIPS PETROLEUM COMPANY (US) | 1999-09-02 | — | — | WO | disclosed |
| US-5830958-A | Polynuclear metallocene preparation and use | PHILLIPS PETROLEUM COMPANY (US) | 1998-11-03 | — | — | US | disclosed |
| EP-0685495-B1 | Method for using a supported metallocene catalyst system | PHILLIPS PETROLEUM CO (US) | 1998-04-08 | — | — | EP | disclosed |
| EP-0810234-A2 | Method for making and using a supported metallocene catalyst system | PHILLIPS PETROLEUM COMPANY (US) | 1997-12-03 | — | — | EP | disclosed |
| US-5498581-A | OLEFIN POLYMERIZATION | PHILLIPS PETROLEUM COMPANY (US) | 1996-03-12 | — | — | US | disclosed |
| EP-0685495-A1 | Method for making and using a supported metallocene catalyst system | PHILLIPS PETROLEUM COMPANY (US) | 1995-12-06 | — | — | EP | disclosed |