Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Benzene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACP1 | P24666 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzene SCHEMBL2148681 | 0.97 | TSHR (0.35) | ACP1TSHRSMN1; SMN2 | |
| Benzene SCHEMBL3130121 | 0.94 | TSHR (0.36) | ACP1TSHRSMN1; SMN2 | |
| Water SCHEMBL9558051 | 0.87 | — | — | |
| SCHEMBL10645073 | 0.87 | — | — | |
| SCHEMBL278347 | 0.83 | — | — | |
| SCHEMBL28227036 | 0.79 | — | — | |
| SCHEMBL28227822 | 0.79 | — | — | |
| SCHEMBL28227840 | 0.79 | — | — | |
| SCHEMBL31707826 | 0.79 | — | — | |
| SCHEMBL28227824 | 0.79 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 113 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2865743-B1 | Improvements in dispensing devices | RECKITT BENCKISER LLC (US) | 2024-03-27 | — | — | EP | disclosed |
| EP-2952570-B1 | IMPROVEMENTS IN DISPENSING DEVICES AND COMPOSITIONS THEREFOR | RECKITT BENCKISER LLC (US) | 2021-07-28 | — | — | EP | disclosed |
| EP-2191077-B1 | CAGELESS DISPENSING DEVICE | RECKITT BENCKISER LLC (US) | 2017-03-15 | — | — | EP | disclosed |
| EP-3088616-A1 | METHOD FOR PRODUCTION OF DISPENSING DEVICES | Reckitt Benckiser LLC (US) | 2016-11-02 | — | — | EP | disclosed |
| EP-2310583-B1 | DISPENSING DEVICE FOR TOILET BOWL | RECKITT BENCKISER LLC (US) | 2016-10-05 | — | — | EP | disclosed |
| US-9334640-B2 | Cageless dispensing device | RECKITT BENCKISER LLC. (US) | 2016-05-10 | — | — | US | disclosed |
| EP-2952570-A1 | IMPROVEMENTS IN DISPENSING DEVICES AND COMPOSITIONS THEREFOR | Reckitt Benckiser LLC (US) | 2015-12-09 | — | — | EP | disclosed |
| EP-1996691-B1 | IMPROVEMENTS IN DISPENSING DEVICES | RECKITT BENCKISER LLC (US) | 2015-05-06 | — | — | EP | disclosed |
| EP-2865743-A1 | Improvements in dispensing devices | Reckitt Benckiser LLC (US) | 2015-04-29 | — | — | EP | disclosed |
| US-8966674-B2 | Dispensing device for toilet bowl | RECKITT BENCKISER LLC (US) | 2015-03-03 | — | — | US | disclosed |
| EP-0133335-A1 | Stabilized bleach-sensitive dyes in automatic dishwasher detergent compositions | UNILEVER N.V. (NL) | 1985-02-20 | — | — | EP | disclosed |
| US-4464281-A | PRECONDITIONED BY AIR FLOW | LEVER BROTHERS COMPANY (US) | 1984-08-07 | — | — | US | disclosed |
| EP-0005618-B1 | DEODORANT PRODUCTS, PREPARATION AND USE THEREOF | UNILEVER PLC (GB) | 1982-06-09 | — | — | EP | disclosed |
| US-4289640-A | IMPROVED FOAMING AND DEGREASING PROPERTIES | COLGATE-PALMOLIVE COMPANY (US) | 1981-09-15 | — | — | US | disclosed |
| US-4193888-A | ABRASIVES, BLEACHING AGENT, DETERGENT, COLORING AGENT | COLGATE-PALMOLIVE COMPANY (US) | 1980-03-18 | — | — | US | disclosed |
| EP-0005618-A1 | Deodorant products, preparation and use thereof | UNILEVER PLC (GB) | 1979-11-28 | — | — | EP | disclosed |
| US-4102799-A | PHOSPHATE-FREE, CONTAINS CITRATE COMPOUND AND INORGANIC BUILDER SALTS SUCH AS SILICATES, CARBONATES, AND SULFATES | COLGATE-PALMOLIVE COMPANY (US) | 1978-07-25 | — | — | US | disclosed |
| US-3966627-A | ALUMINUM SILICATE, BUILDER SALT | COLGATE-PALMOLIVE COMPANY (US) | 1976-06-29 | — | — | US | disclosed |
| US-3965015-A | DETERGENT, AN UREA OR THIOUREA | COLGATE-PALMOLIVE COMPANY (US) | 1976-06-22 | — | — | US | disclosed |
| US-3962149-A | NON-PHOSPHATE SPRAY DRIED DETERGENTS CONTAINING DICARBOXYLIC ACID SALTS | COLGATE-PALMOLIVE COMPANY (US) | 1976-06-08 | — | — | US | disclosed |