Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Methylhydrazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methylhydrazine SCHEMBL29201448 | 0.94 | — | — | |
| Methylhydrazine SCHEMBL28476147 | 0.94 | — | — | |
| Methylhydrazine SCHEMBL3175579 | 0.93 | — | — | |
| Methylhydrazine SCHEMBL3103 | 0.93 | — | — | |
| Methylhydrazine SCHEMBL4168780 | 0.86 | — | — | |
| Methylhydrazine SCHEMBL8172656 | 0.86 | — | — | |
| Methylhydrazine SCHEMBL1472053 | 0.86 | — | — | |
| Methylhydrazine SCHEMBL30951729 | 0.86 | — | — | |
| Methylhydrazine SCHEMBL437692 | 0.86 | — | — | |
| Methylhydrazine SCHEMBL8766840 | 0.86 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 194 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119269704-A | Method for measuring methyl hydrazine content by pre-column derivatization-high performance liquid chromatography | 湖北泰盛化工有限公司 | 2025-01-07 | — | — | CN | claimed |
| CN-116574028-B | Preparation method of high-purity methyl hydrazine | 北京航天凯恩新材料有限公司 | 2024-11-29 | — | — | CN | claimed |
| CN-116574028-A | Preparation method of high-purity methyl hydrazine | 北京航天凯恩新材料有限公司 | 2023-08-11 | — | — | CN | claimed |
| CN-115819346-A | Synthetic method of 3- (difluoromethyl) -1-methyl-1H-pyrazole-4-ethyl formate | 湖南化工研究院有限公司 | 2023-03-21 | — | — | CN | claimed |
| CN-112480008-B | Synthesis method of 1-methyl-5-hydroxypyrazole | 浙江工业大学 | 2022-10-11 | — | — | CN | claimed |
| CN-112094210-A | Preparation method of substituted sulfinate | 江苏扬农化工股份有限公司 | 2020-12-18 | — | — | CN | claimed |
| CN-107098934-B | A kind of method of phthalic aldehyde derivative phosphoramidite monomer, synthetic method and the quick coupling protein matter of DNA | 厦门大学 | 2019-03-12 | — | — | CN | claimed |
| US-20150353501-A1 | PROCESS FOR THE PREPARATION OF ALKYL 3-DIFLUOROMETHYL-1-METHYL-1H-PYRAZOLE-4-CARBOXYLATE AND ITS ANALOGS | KingChem LLC. | 2015-12-10 | — | — | US | claimed |
| EP-2951145-A1 | PREPARATION OF ALKYL 3-DIFLUOROMETHYL-1-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID ESTER | Kingchem, LLC (US) | 2015-12-09 | — | — | EP | claimed |
| US-9139507-B2 | Process for the preparation of alkyl 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylate and its analogs | KingChem LLC. (US) | 2015-09-22 | — | — | US | claimed |
| WO-2015085464-A1 | PROCESS FOR PREPARING ALKYL 3-DIFLUOROMETHYL-1-METHYL-1H-PYRAZOLE-4-CARBOXYLATE AND ITS ANALOGS | KING CHEM, LLC (US) | 2015-06-18 | — | — | WO | claimed |
| US-20150158808-A1 | A PROCESS FOR THE PREPARATION OF ALKYL 3-DIFLUOROMETHYL-1-METHYL-1H-PYRAZOLE-4-CARBOXYLATE AND ITS ANALOGS | KingChem LLC. | 2015-06-11 | — | — | US | claimed |
| US-8957254-B2 | Process for chemical synthesis from an alkenone made from a halogenated precursor | SOLVAY SA (BE) | 2015-02-17 | — | — | US | claimed |
| US-8871947-B2 | Preparation of alkyl 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid ester | KingChem LLC (US) | 2014-10-28 | — | — | US | claimed |
| CN-104105684-A | Preparation of alkyl 3-difluoromethyl-1-methyl-1h-pyrazole-4-carboxylic acid ester | KingChem LLC | 2014-10-15 | — | — | CN | claimed |
| WO-2014120397-A1 | PREPARATION OF ALKYL 3-DIFLUOROMETHYL-1-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID ESTER | KINGCHEM, LLC (US) | 2014-08-07 | — | — | WO | claimed |
| US-20140221669-A1 | PREPARATION OF ALKYL 3-DIFLUOROMETHYL-1-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID ESTER | KingChem LLC | 2014-08-07 | — | — | US | claimed |
| US-20140051892-A1 | Process for chemical synthesis from an alkenone made from a halogenated precursor | SOLVAY SA (BE) | 2014-02-20 | — | — | US | claimed |
| EP-1871753-B1 | PREPARATION OF TAXANES FROM 9-DIHYDRO-13-ACETYLBACCATIN III | ACCORD HEALTHCARE INC (CA) | 2012-07-18 | — | — | EP | claimed |
| JP-1156963-A | — | — | None | — | — | JP | disclosed |
| CN-119269704-A | Method for measuring methyl hydrazine content by pre-column derivatization-high performance liquid chromatography | 湖北泰盛化工有限公司 | 2025-01-07 | — | — | CN | disclosed |
| CN-119269704-A | Method for measuring methyl hydrazine content by pre-column derivatization-high performance liquid chromatography | 湖北泰盛化工有限公司 | 2025-01-07 | — | — | CN | disclosed |
| CN-119100988-A | Preparation method of hydroxypyrazole derivative under action of alkali | 山东京博农化科技股份有限公司 | 2024-12-10 | — | — | CN | disclosed |
| CN-116574028-B | Preparation method of high-purity methyl hydrazine | 北京航天凯恩新材料有限公司 | 2024-11-29 | — | — | CN | disclosed |
| CN-116574028-B | Preparation method of high-purity methyl hydrazine | 北京航天凯恩新材料有限公司 | 2024-11-29 | — | — | CN | disclosed |
| WO-2024119117-A1 | MODIFIED 5' CAP FOR MRNA AND METHODS OF USE THEREOF | PRIME MEDICINE, INC. (US) | 2024-06-06 | — | — | WO | disclosed |
| CN-117919755-A | Energy-saving system for methyl hydrazine concentration section by ammonia chloride method | 营口福康精细化工科技有限公司 | 2024-04-26 | — | — | CN | disclosed |
| WO-2024069235-A2 | COMPOSITIONS CONTAINING OLIGONUCLEOTIDES WITH THERANOSTIC APPLICATIONS | Sixfold Bioscience Ltd. (GB) | 2024-04-04 | — | — | WO | disclosed |
| EP-4323517-A2 | COMPOSITIONS CONTAINING NUCLEIC ACID NANOPARTICLES AND PROCESSES RELATED TO ALTERATION OF THEIR PHYSICOCHEMICAL CHARACTERISTICS | Sixfold Bioscience Ltd. (GB) | 2024-02-21 | — | — | EP | disclosed |
| CN-219579916-U | Device for preparing high-purity methyl hydrazine | 北京航天凯恩新材料有限公司 | 2023-08-25 | — | — | CN | disclosed |
| CN-116574028-A | Preparation method of high-purity methyl hydrazine | 北京航天凯恩新材料有限公司 | 2023-08-11 | — | — | CN | disclosed |
| CN-116574028-A | Preparation method of high-purity methyl hydrazine | 北京航天凯恩新材料有限公司 | 2023-08-11 | — | — | CN | disclosed |
| CN-115232023-B | Process for catalytic synthesis of methyl hydrazine | 东力（南通）化工有限公司 | 2023-08-04 | — | — | CN | disclosed |
| US-20230183746-A1 | COMPOSITIONS FOR TRANSFER OF CARGO TO CELLS | Sixfold Bioscience Ltd. (GB) | 2023-06-15 | — | — | US | disclosed |
| CN-115997016-A | Composition comprising nucleic acid nanoparticles having modular functional groups | 西克斯福德生物科学有限公司 | 2023-04-21 | — | — | CN | disclosed |
| CN-115819346-A | Synthetic method of 3- (difluoromethyl) -1-methyl-1H-pyrazole-4-ethyl formate | 湖南化工研究院有限公司 | 2023-03-21 | — | — | CN | disclosed |
| CN-115819346-A | Synthetic method of 3- (difluoromethyl) -1-methyl-1H-pyrazole-4-ethyl formate | 湖南化工研究院有限公司 | 2023-03-21 | — | — | CN | disclosed |
| EP-4143316-A2 | COMPOSITIONS CONTAINING NUCLEIC ACID NANOPARTICLES WITH MODULAR FUNCTIONALITY | Sixfold Bioscience Ltd. (GB) | 2023-03-08 | — | — | EP | disclosed |
| EP-4103577-A1 | NOVEL MRNA 5'-END CAP ANALOGS, RNA MOLECULE INCORPORATING THE SAME, USES THEREOF AND METHOD OF SYNTHESIZING RNA MOLECULE OR PEPTIDE | Uniwersytet Warszawski (PL) | 2022-12-21 | — | — | EP | disclosed |
| CN-112939893-B | Synthesis method of 4- (4-aminophenyl) -3-morpholinone | 普济生物科技（台州）有限公司 | 2022-08-23 | — | — | CN | disclosed |
| EP-4022058-A2 | COMPOSITIONS FOR TRANSFER OF CARGO TO CELLS | Sixfold Bioscience Ltd. (GB) | 2022-07-06 | — | — | EP | disclosed |
| US-11357865-B2 | Compositions containing nucleic acid nanoparticles with modular functionality | Sixfold Bioscience Ltd. (GB) | 2022-06-14 | — | — | US | disclosed |
| US-11358937-B2 | Reagents based on a tertiary amine backbone to introduce chemical functionality in nucleic acids and sequence-controlled polymers | THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY (CA) | 2022-06-14 | — | — | US | disclosed |
| CN-112441978-B | Preparation method of 1-methyl-5-hydroxypyrazole-4-carboxylic acid ethyl ester | 江西天宇化工有限公司 | 2022-04-26 | — | — | CN | disclosed |
| CN-114292208-A | Method for preparing methylhydrazine by solid acid catalysis | 杭州新本立医药有限公司 | 2022-04-08 | — | — | CN | disclosed |
| CN-112694448-B | Process for the preparation of triazine rings | 山东金城柯瑞化学有限公司 | 2022-02-22 | — | — | CN | disclosed |
| CN-113979944-A | Synthesis method of high-selectivity 1-methyl-3- (trifluoromethyl) -1H-pyrazole-5-alcohol | 杭州欧晨科技有限公司 | 2022-01-28 | — | — | CN | disclosed |
| CN-113979944-A | Synthesis method of high-selectivity 1-methyl-3- (trifluoromethyl) -1H-pyrazole-5-alcohol | 杭州欧晨科技有限公司 | 2022-01-28 | — | — | CN | disclosed |
| WO-2021220053-A2 | COMPOSITIONS CONTAINING NUCLEIC ACID NANOPARTICLES WITH MODULAR FUNCTIONALITY | Sixfold Bioscience Ltd. (GB) | 2021-11-04 | — | — | WO | disclosed |
| US-20210330810-A1 | COMPOSITIONS CONTAINING NUCLEIC ACID NANOPARTICLES WITH MODULAR FUNCTIONALITY | Sixfold Bioscience Ltd. (GB) | 2021-10-28 | — | — | US | disclosed |
| US-20210324198-A1 | SILICON-SUBSTITUTED RHODAMINE DYES AND DYE CONJUGATES | Life Technologies Corporation | 2021-10-21 | — | — | US | disclosed |
| WO-2021162567-A1 | NOVEL MRNA 5'-END CAP ANALOGS, RNA MOLECULE INCORPORATING THE SAME, USES THEREOF AND METHOD OF SYNTHESIZING RNA MOLECULE OR PEPTIDE | UNIWERSYTET WARSZAWSKI (PL) | 2021-08-19 | — | — | WO | disclosed |
| WO-2021140636-A1 | STRETCHABLE FILM | 株式会社ダイセル | 2021-07-15 | — | — | WO | disclosed |
| EP-3833673-A1 | REAGENTS BASED ON A TERTIARY AMINE BACKBONE TO INTRODUCE CHEMICAL FUNCTIONALITY IN NUCLEIC ACIDS AND SEQUENCE-CONTROLLED POLYMERS | The Royal Institution for the Advancement of Learning / McGill University (CA) | 2021-06-16 | — | — | EP | disclosed |
| CN-112939893-A | Synthesis method of 4- (4-aminophenyl) -3-morpholinone | 普济生物科技（台州）有限公司 | 2021-06-11 | — | — | CN | disclosed |
| US-20210163422-A1 | REAGENTS BASED ON A TERTIARY AMINE BACKBONE TO INTRODUCE CHEMICAL FUNCTIONALITY IN NUCLEIC ACIDS AND SEQUENCE-CONTROLLED POLYMERS | THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY (CA) | 2021-06-03 | — | — | US | disclosed |
| CN-112566986-A | Silicon-substituted rhodamine dyes and dye conjugates | 生命技术公司 | 2021-03-26 | — | — | CN | disclosed |
| CN-112441978-A | Preparation method of 1-methyl-5-hydroxypyrazole-4-carboxylic acid ethyl ester | 江西天宇化工有限公司 | 2021-03-05 | — | — | CN | disclosed |
| CN-112094210-A | Preparation method of substituted sulfinate | 江苏扬农化工股份有限公司 | 2020-12-18 | — | — | CN | disclosed |
| US-10786582-B2 | Gd(III)-dithiolane gold nanoparticle conjugates | NORTHWESTERN UNIVERSITY (US) | 2020-09-29 | — | — | US | disclosed |
| WO-2020142825-A1 | REAGENTS BASED ON A TERTIARY AMINE BACKBONE TO INTRODUCE CHEMICAL FUNCTIONALITY IN NUCLEIC ACIDS AND SEQUENCE-CONTROLLED POLYMERS | THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY (CA) | 2020-07-16 | — | — | WO | disclosed |
| CN-107406373-B | Boron-containing diacylhydrazine compounds | 英特瑞克斯顿股份有限公司 | 2020-04-28 | — | — | CN | disclosed |
| EP-3194359-B1 | BORON-CONTAINING DIACYLHYDRAZINE COMPOUNDS | INTREXON CORP (US) | 2020-04-08 | — | — | EP | disclosed |
| WO-2020053373-A1 | NOVEL TRF1 MODULATORS AND ANALOGUES THEREOF | Fundación Del Sector Público Estatal Centro Nacional De Investigaciones Oncológicas Carlos III (F.S.P. CNIO) (ES) | 2020-03-19 | — | — | WO | disclosed |
| EP-3623370-A1 | NOVEL TRF1 MODULATORS AND ANALOGUES THEREOF | Fundación del Sector Público Estatal Centro Nacional de Investigaciones Oncológicas Carlos III (F.S.P. CNIO) (ES) | 2020-03-18 | — | — | EP | disclosed |
| US-10570158-B2 | Boron-containing diacylhydrazine compounds | INTREXON CORPORATION (US) | 2020-02-25 | — | — | US | disclosed |
| US-10544146-B2 | Bicyclic compounds and their use as antibacterial agents and β-lactamase inhibitors | FEDORA PHARMACEUTICALS INC. (CA) | 2020-01-28 | — | — | US | disclosed |
| US-20190321492-A1 | Gd(III)-Dithiolane Gold Nanoparticle Conjugates | NORTHWESTERN UNIVERSITY | 2019-10-24 | — | — | US | disclosed |
| US-10406249-B2 | Gd(III)-dithiolane gold nanoparticle conjugates | NORTHWESTERN UNIVERSITY (US) | 2019-09-10 | — | — | US | disclosed |
| CN-109574853-A | For synthesizing method, catalyst and its application of amino benzenes compounds | 普济生物科技（台州）有限公司 | 2019-04-05 | — | — | CN | disclosed |
| CN-109475531-A | The heterocycle inhibitor of PTPN11 | 得克萨斯州立大学董事会 | 2019-03-15 | — | — | CN | disclosed |
| CN-107098934-B | A kind of method of phthalic aldehyde derivative phosphoramidite monomer, synthetic method and the quick coupling protein matter of DNA | 厦门大学 | 2019-03-12 | — | — | CN | disclosed |
| CN-109336921-A | DNA base analog, purposes and its synthetic method | 厦门大学 | 2019-02-15 | — | — | CN | disclosed |
| CN-109097032-A | The preparation method of carbon quantum dot fluorescent material and its application in copper ion detection | 上海大学 | 2018-12-28 | — | — | CN | disclosed |
| US-10125363-B2 | Compositions and methods for the treatment of parkinson disease by the selective delivery of oligonucleotide molecules to specific neuron types | NLIFE THERAPEUTICS, S.L. (ES) | 2018-11-13 | — | — | US | disclosed |
| EP-3398941-A1 | HETEROCYCLIC P2X7 ANTAGONISTS | AXXAM S.p.A. (IT) | 2018-11-07 | — | — | EP | disclosed |
| US-20180305359-A1 | BICYCLIC COMPOUNDS AND THEIR USE AS ANTIBACTERIAL AGENTS AND BETA-LACTAMASE INHIBITORS | FEDORA PHARMACEUTICALS INC. (CA) | 2018-10-25 | — | — | US | disclosed |
| CN-108682466-A | A kind of oxidation unit and method of the feed liquid containing plutonium | 中国原子能科学研究院 | 2018-10-19 | — | — | CN | disclosed |
| US-10030019-B2 | Bicyclic compounds and their use as antibacterial agents and β-lactamase inhibitors | FEDORA PHARMACEUTICALS INC. (CA) | 2018-07-24 | — | — | US | disclosed |
| US-20180201628-A1 | Boron-Containing Diacylhydrazine Compounds | INTREXON CORP (US) | 2018-07-19 | — | — | US | disclosed |
| CN-107980001-A | Compounds and compositions comprising phosphorothioated oligodeoxynucleotides and methods of use thereof | 希望之城 | 2018-05-01 | — | — | CN | disclosed |
| US-9944659-B2 | Boron-containing diacylhydrazine compounds | INTREXON CORPORATION (US) | 2018-04-17 | — | — | US | disclosed |
| CN-106543026-B | A kind of preparation method of methyl hydrazine | 石家庄金派医药化工有限公司 | 2018-01-16 | — | — | CN | disclosed |
| CN-107406373-A | Boron-containing diacylhydrazine compounds | 英特瑞克斯顿股份有限公司 | 2017-11-28 | — | — | CN | disclosed |
| EP-3194359-A1 | BORON-CONTAINING DIACYLHYDRAZINE COMPOUNDS | Intrexon Corporation (US) | 2017-07-26 | — | — | EP | disclosed |
| CN-106543026-A | A kind of preparation method of methyl hydrazine | 重庆锦杉科技有限公司 | 2017-03-29 | — | — | CN | disclosed |
| CN-104379551-B | The preparation method of 3 difluoromethyl, 1 methyl 1H pyrazoles 4 alkyl carboxylates and the like | 金凯有限责任公司 | 2017-03-08 | — | — | CN | disclosed |
| US-20160375154-A1 | Gd(III)-Dithiolane Gold Nanoparticle Conjugates | NORTHWESTERN UNIVERSITY | 2016-12-29 | — | — | US | disclosed |
| US-9505761-B2 | Bicyclic compounds and their use as antibacterial agents and beta-lactamase inhibitors | FEDORA PHARMACEUTICALS INC. (CA) | 2016-11-29 | — | — | US | disclosed |
| US-20160297817-A1 | BICYCLIC COMPOUNDS AND THEIR USE AS ANTIBACTERIAL AGENTS AND BETA-LACTAMASE INHIBITORS | FEDORA PHARMACEUTICALS INC. (CA) | 2016-10-13 | — | — | US | disclosed |
| CN-105873930-A | Novel bicyclic compounds and their use as antibacterial agents and beta-lactamase inhibitors | 费多拉制药公司 | 2016-08-17 | — | — | CN | disclosed |
| US-9393239-B2 | Bicyclic compounds and their use as antibacterial agents and betalactamase inhibitors | FEDORA PHARMACEUTICALS INC. (CA) | 2016-07-19 | — | — | US | disclosed |
| WO-2016044390-A1 | BORON-CONTAINING DIACYLHYDRAZINE COMPOUNDS | INTREXON CORPORATION (US) | 2016-03-24 | — | — | WO | disclosed |
| US-20160083726-A1 | Compositions and Methods for the Treatment of Parkinson Disease by the Selective Delivery of Oligonucleotide Molecules to Specific Neuron Types | PALOMO LIMITED (CY) | 2016-03-24 | — | — | US | disclosed |
| US-20160083403-A1 | Boron-Containing Diacylhydrazine Compounds | INTREXON CORPORATION | 2016-03-24 | — | — | US | disclosed |
| US-20150353501-A1 | PROCESS FOR THE PREPARATION OF ALKYL 3-DIFLUOROMETHYL-1-METHYL-1H-PYRAZOLE-4-CARBOXYLATE AND ITS ANALOGS | KingChem LLC. | 2015-12-10 | — | — | US | disclosed |
| EP-2951145-A1 | PREPARATION OF ALKYL 3-DIFLUOROMETHYL-1-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID ESTER | Kingchem, LLC (US) | 2015-12-09 | — | — | EP | disclosed |
| US-9193969-B2 | Compositions and methods for selective delivery of oligonucleotide molecules to specific neuron types | NLIFE THERAPEUTICS, S.L. (ES) | 2015-11-24 | — | — | US | disclosed |
| EP-2931723-A1 | NEW BICYCLIC COMPOUNDS AND THEIR USE AS ANTIBACTERIAL AGENTS AND -LACTAMASE INHIBITORS | Fedora Pharmaceuticals Inc. (CA) | 2015-10-21 | — | — | EP | disclosed |
| US-9139507-B2 | Process for the preparation of alkyl 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylate and its analogs | KingChem LLC. (US) | 2015-09-22 | — | — | US | disclosed |
| US-9084825-B2 | Compositions and methods for the treatment of parkinson disease by the selective delivery of oligonucleotide molecules to specific neuron types | NLIFE THERAPEUTICS, S.L. (ES) | 2015-07-21 | — | — | US | disclosed |
| WO-2015085464-A1 | PROCESS FOR PREPARING ALKYL 3-DIFLUOROMETHYL-1-METHYL-1H-PYRAZOLE-4-CARBOXYLATE AND ITS ANALOGS | KING CHEM, LLC (US) | 2015-06-18 | — | — | WO | disclosed |
| US-20150158808-A1 | A PROCESS FOR THE PREPARATION OF ALKYL 3-DIFLUOROMETHYL-1-METHYL-1H-PYRAZOLE-4-CARBOXYLATE AND ITS ANALOGS | KingChem LLC. | 2015-06-11 | — | — | US | disclosed |
| US-8957254-B2 | Process for chemical synthesis from an alkenone made from a halogenated precursor | SOLVAY SA (BE) | 2015-02-17 | — | — | US | disclosed |
| US-8877743-B2 | Bicyclic compounds and their use as antibacterial agents and β-lactamase inhibitors | NAEJA PHARMACEUTICAL INC. (CA) | 2014-11-04 | — | — | US | disclosed |
| US-8871947-B2 | Preparation of alkyl 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid ester | KingChem LLC (US) | 2014-10-28 | — | — | US | disclosed |
| CN-104105684-A | Preparation of alkyl 3-difluoromethyl-1-methyl-1h-pyrazole-4-carboxylic acid ester | KingChem LLC | 2014-10-15 | — | — | CN | disclosed |
| US-20140288051-A1 | BICYCLIC COMPOUNDS AND THEIR USE AS ANTIBACTERIAL AGENTS AND BETA-LACTAMASE INHIBITORS | FEDORA PHARMACEUTICALS INC. (CA) | 2014-09-25 | — | — | US | disclosed |
| US-20140221341-A1 | BICYCLIC COMPOUNDS AND THEIR USE AS ANTIBACTERIAL AGENTS AND BETALACTAMASE INHIBITORS | NAEJA PHARMACEUTICAL INC. (CA) | 2014-08-07 | — | — | US | disclosed |
| WO-2014120397-A1 | PREPARATION OF ALKYL 3-DIFLUOROMETHYL-1-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID ESTER | KINGCHEM, LLC (US) | 2014-08-07 | — | — | WO | disclosed |
| US-20140221669-A1 | PREPARATION OF ALKYL 3-DIFLUOROMETHYL-1-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID ESTER | KingChem LLC | 2014-08-07 | — | — | US | disclosed |
| US-8796257-B2 | Bicyclic compounds and their use as antibacterial agents and β-lactamase inhibitors | NAEJA PHARMACEUTICAL INC. (CA) | 2014-08-05 | — | — | US | disclosed |
| WO-2014091268-A1 | NEW BICYCLIC COMPOUNDS AND THEIR USE AS ANTIBACTERIAL AGENTS AND β-LACTAMASE INHIBITORS | NAEJA PHARMACEUTICAL INC. (CA) | 2014-06-19 | — | — | WO | disclosed |
| US-20140120158-A1 | Compositions and Methods for the Treatment of Parkinson Disease by the Selective Delivery of Oligonucleotide Molecules to Specific Neuron Types | PALOMO LIMITED (CY) | 2014-05-01 | — | — | US | disclosed |
| US-20140051892-A1 | Process for chemical synthesis from an alkenone made from a halogenated precursor | SOLVAY SA (BE) | 2014-02-20 | — | — | US | disclosed |
| US-20130281359-A1 | NEW BICYCLIC COMPOUNDS AND THEIR USE AS ANTIBACTERIAL AGENTS AND BETA-LACTAMASE INHIBITORS | FEDORA PHARMACEUTICALS INC. (CA) | 2013-10-24 | — | — | US | disclosed |
| US-20130225554-A1 | NEW BICYCLIC COMPOUNDS AND THEIR USE AS ANTIBACTERIAL AGENTS AND BETA-LACTAMASE INHIBITORS | NAEJA PHARMACEUTICAL INC. (CA) | 2013-08-29 | — | — | US | disclosed |
| CN-101072758-B | Quinazoline derivatives | ASTRAZENECA AB | 2013-07-31 | — | — | CN | disclosed |
| US-20120322991-A1 | Compositions and methods for selective delivery of oligonucleotide molecules to specific neuron types | NLIFE THERAPEUTICS, S.L. (ES) | 2012-12-20 | — | — | US | disclosed |
| EP-1871753-B1 | PREPARATION OF TAXANES FROM 9-DIHYDRO-13-ACETYLBACCATIN III | ACCORD HEALTHCARE INC (CA) | 2012-07-18 | — | — | EP | disclosed |
| US-20120165351-A1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2012-06-28 | — | — | US | disclosed |
| US-8206914-B2 | Evolving new molecular function | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2012-06-26 | — | — | US | disclosed |
| US-8153643-B2 | Quinazoline derivatives | ASTRAZENECA AB (SE) | 2012-04-10 | — | — | US | disclosed |
| EP-1441011-B1 | Energy transfer dye containing an aromatic-substituted xanthene dye as donor dye and/or acceptor dye | LIFE TECHNOLOGIES CORP (US) | 2012-02-22 | — | — | EP | disclosed |
| EP-1802591-B1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2012-01-11 | — | — | EP | disclosed |
| US-20110190141-A1 | Evolving New Molecular Function | PRESIDENT AND FELLOWS OF HAVARD COLLEGE (US) | 2011-08-04 | — | — | US | disclosed |
| US-7771935-B2 | Evolving new molecular function | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2010-08-10 | — | — | US | disclosed |
| CN-101245030-B | Process for producing 1,2-bis(2,4-diaminophenyloxy)benzene | UNIV DONGHUA | 2010-06-30 | — | — | CN | disclosed |
| US-7667033-B2 | Compositions and methods for the use of FMOC derivatives in DNA/RNA synthesis | SYNGEN, INC. (US) | 2010-02-23 | — | — | US | disclosed |
| US-20090233924-A1 | Quinazoline derivatives | ASTRAZENECA AB (SE) | 2009-09-17 | — | — | US | disclosed |
| US-20090171076-A1 | COMPOSITIONS AND METHODS FOR THE USE OF FMOC DERIVATIVES IN DNA/RNA SYNTHESIS | SYNGEN, INC. | 2009-07-02 | — | — | US | disclosed |
| CN-101367853-A | 13-membered azalides and their use as antibiotic agents | PFIZER PROD INC (US) | 2009-02-18 | — | — | CN | disclosed |
| US-7491494-B2 | Evolving new molecular function | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2009-02-17 | — | — | US | disclosed |
| CN-101245023-A | Process for producing 2,2-bis[2,4-diaminophenyloxy)phenyl]hexafluoropropane | UNIV DONGHUA (CN) | 2008-08-20 | — | — | CN | disclosed |
| CN-101245025-A | Process for producing 1,3-bis(2,4-diaminophenyloxy)naphthalin | UNIV DONGHUA (CN) | 2008-08-20 | — | — | CN | disclosed |
| CN-101245031-A | Process for producing 1,2-bis(2,4-diaminophenyloxy)naphthalin | UNIV DONGHUA (CN) | 2008-08-20 | — | — | CN | disclosed |
| CN-101245022-A | Process for producing 3,5-bis(2,4-diaminophenyloxy)-2-naphthoic acid | UNIV DONGHUA (CN) | 2008-08-20 | — | — | CN | disclosed |
| CN-101245026-A | Process for producing 1,4-(2,4-diaminophenyloxy)-2,5-di-t-butyl benzene | UNIV DONGHUA (CN) | 2008-08-20 | — | — | CN | disclosed |
| CN-101245024-A | Process for producing 1,3-bis(2,4-diaminophenyloxy)benzene | UNIV DONGHUA (CN) | 2008-08-20 | — | — | CN | disclosed |
| CN-101245028-A | Process for producing 2,2-bis[3-amido-4-(4-aminophenoxy)phenyl] hexafluoropropane | UNIV DONGHUA (CN) | 2008-08-20 | — | — | CN | disclosed |
| CN-101245030-A | Process for producing 1,2-bis(2,4-diaminophenyloxy)benzene | UNIV DONGHUA (CN) | 2008-08-20 | — | — | CN | disclosed |
| CN-101245027-A | Process for producing 2,2-bis[3-amido-4-(4-aminophenoxy)phenyl]propane | UNIV DONGHUA (CN) | 2008-08-20 | — | — | CN | disclosed |
| CN-101072758-A | Quinazoline derivatives | ASTRAZENECA AB (SE) | 2007-11-14 | — | — | CN | disclosed |
| EP-1802591-A1 | QUINAZOLINE DERIVATIVES | AstraZeneca AB (SE) | 2007-07-04 | — | — | EP | disclosed |
| US-7179906-B2 | Asymmetric benzoxanthene dyes | APPLERA CORPORATION (US) | 2007-02-20 | — | — | US | disclosed |
| EP-1540013-A4 | EVOLVING NEW MOLECULAR FUNCTION | HARVARD COLLEGE (US) | 2006-06-28 | — | — | EP | disclosed |
| WO-2006040520-A1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2006-04-20 | — | — | WO | disclosed |
| US-20050170376-A1 | Evolving new molecular function | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2005-08-04 | — | — | US | disclosed |
| EP-1540013-A2 | EVOLVING NEW MOLECULAR FUNCTION | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2005-06-15 | — | — | EP | disclosed |
| US-20050107617-A1 | Mobility-modifying cyanine dyes | APPLERA CORPORATION (US) | 2005-05-19 | — | — | US | disclosed |
| US-20040225119-A1 | Fluorescent dyes for use as diagnostic/signalling tool in nucleotide sequence analysis | APPLERA CORPORATION (US) | 2004-11-11 | — | — | US | disclosed |
| EP-0786468-B1 | Solid support reagents for the direct synthesis of 3'-labeled polynucleotides | APPLERA CORP (US) | 2004-10-13 | — | — | EP | disclosed |
| US-20040180412-A1 | Evolving new molecular function | THE PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2004-09-16 | — | — | US | disclosed |
| EP-1244749-B1 | MOBILITY-MODIFYING CYANINE DYES | APPLERA CORP (US) | 2004-09-01 | — | — | EP | disclosed |
| EP-1441011-A1 | Energy transfer dye containing an aromatic-substituted xanthene dye as donor dye and/or acceptor dye | Applera Corporation (US) | 2004-07-28 | — | — | EP | disclosed |
| US-6716994-B1 | FLUORESCENCE BASED FOUR COLOR NUCLEIC ACID SEQUENCING | APPLERA CORPORATION | 2004-04-06 | — | — | US | disclosed |
| EP-1019453-B1 | AROMATIC-SUBSTITUTED XANTHENE DYES | APPLERA CORP (US) | 2004-03-31 | — | — | EP | disclosed |
| EP-1131331-B1 | 13-MEMBERED AZALIDES AND THEIR USE AS ANTIBIOTIC AGENTS | PFIZER PROD INC (US) | 2004-03-03 | — | — | EP | disclosed |
| WO-2004016767-A2 | EVOLVING NEW MOLECULAR FUNCTION | THE PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2004-02-26 | — | — | WO | disclosed |
| US-6673550-B2 | PROBES FOR USE IN THE DETECTION AND MEASUREMENT OF PREFERENTIAL COMPOUND IN SAMPLE | ACLARA BIOSCIENCES, INC. | 2004-01-06 | — | — | US | disclosed |
| EP-0877751-B1 | LINKER ARM FOR SOLID SUPPORT OLIGONUCLEOTIDE SYNTHESIS AND PROCESS FOR PRODUCTION THEREOF | UNIV TECHNOLOGIES INT (CA) | 2003-10-15 | — | — | EP | disclosed |
| US-20030185878-A1 | Process for producing phospholipid-containing drug | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2003-10-02 | — | — | US | disclosed |
| US-20030158245-A1 | Fused heterocyclic derivatives, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2003-08-21 | — | — | US | disclosed |
| US-20030129593-A1 | Process for producing multiple oligonucleotides on a solid support | UNIVERSITY TECHNOLOGIES INTERNATIONAL INC. | 2003-07-10 | — | — | US | disclosed |
| EP-1293197-A1 | PROCESS FOR PRODUCING PHOSPHOLIPID-CONTAINING DRUGS | Takeda Chemical Industries, Ltd. (JP) | 2003-03-19 | — | — | EP | disclosed |
| EP-1268486-A2 | FUSED HETEROCYCLIC DERIVATIVES, THEIR PRODUCTION AND USE | Takeda Chemical Industries, Ltd. (JP) | 2003-01-02 | — | — | EP | disclosed |
| US-20020146726-A1 | Electrophoretic tag reagents comprising fluorescent compounds | ACLARA BIOSCIENCES, INC. | 2002-10-10 | — | — | US | disclosed |
| US-20020142329-A1 | Compositions and methods employing cleavable electrophoretic tag reagents | ACLARA BIOSCIENCES, INC. | 2002-10-03 | — | — | US | disclosed |
| EP-1244749-A2 | MOBILITY-MODIFYING CYANINE DYES | Applera Corporation (US) | 2002-10-02 | — | — | EP | disclosed |
| US-6348596-B1 | NUCLEIC ACID HYBRIDIZATION ASSAYS; DNA SEQUENCE DETERMINATION | PE CORPORATION (NY) | 2002-02-19 | — | — | US | disclosed |
| CN-1326460-A | Trideca-tertiary azalides and their use as antibiotics | PFIZER PROD INC (US) | 2001-12-12 | — | — | CN | disclosed |
| US-6329345-B1 | 13-membered azalides and their use as antibiotic agents | PFIZER INC | 2001-12-11 | — | — | US | disclosed |
| US-6303775-B1 | POLYNUCLEOTIDE LABELED WITH SPECIFIC FLUORESCENT DYE; NONRADIOACTIVE ANALYSIS | THE PERKIN-ELMER CORPORATION | 2001-10-16 | — | — | US | disclosed |
| WO-2001074823-A2 | FUSED HETEROCYCLIC DERIVATIVES, THEIR PRODUCTION AND USE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-10-11 | — | — | WO | disclosed |
| EP-1131331-A1 | 13-MEMBERED AZALIDES AND THEIR USE AS ANTIBIOTIC AGENTS | Pfizer Products Inc. (US) | 2001-09-12 | — | — | EP | disclosed |
| WO-2001049790-A2 | MOBILITY-MODIFYING CYANINE DYES | APPLERA CORPORATION (US) | 2001-07-12 | — | — | WO | disclosed |
| EP-1019453-A1 | AROMATIC-SUBSTITUTED XANTHENE DYES | THE PERKIN-ELMER CORPORATION (US) | 2000-07-19 | — | — | EP | disclosed |
| WO-2000031097-A1 | 13-MEMBERED AZALIDES AND THEIR USE AS ANTIBIOTIC AGENTS | PFIZER PRODUCTS INC. (US) | 2000-06-02 | — | — | WO | disclosed |
| US-6020481-A | FLUORESCENT LABELING REAGENTS; DIDEOXY POLYNUCLEOTIDE SEQUENCING AND FRAGMENT ANALYSIS METHODS. | THE PERKIN-ELMER CORPORATION (US) | 2000-02-01 | — | — | US | disclosed |
| US-6015895-A | REACTING A LINKER COMPOUND WITH A HYDROXY GROUP OF A NUCLEOSIDE AND A SOLID SUPPORT CAPABLE OF ESTERIFICATION; LINKER IS STABILE AGAINST SPONTANEOUS HYDROLYSIS AND EASILY CLEAVED WHEN NECESSARY | UNIVERSITY TECHNOLOGIES INTERNATIONAL INC. (CA) | 2000-01-18 | — | — | US | disclosed |
| US-6008379-A | USEFUL AS FLUORESCENT DYES FOR LABELING | THE PERKIN-ELMER CORPORATION (US) | 1999-12-28 | — | — | US | disclosed |
| EP-0891393-B1 | ASYMMETRIC BENZOXANTHENE DYES | PERKIN ELMER CORP (US) | 1999-06-30 | — | — | EP | disclosed |
| WO-1999016832-A1 | AROMATIC-SUBSTITUTED XANTHENE DYES | THE PERKIN-ELMER CORPORATION (US) | 1999-04-08 | — | — | WO | disclosed |
| EP-0891393-A1 | ASYMMETRIC BENZOXANTHENE DYES | THE PERKIN-ELMER CORPORATION (US) | 1999-01-20 | — | — | EP | disclosed |
| US-5840999-A | NAPHTHOL INTERMEDIATES FOR FLUORESCENT DYES | THE PERKIN-ELMER CORPORATION (US) | 1998-11-24 | — | — | US | disclosed |
| EP-0877751-A1 | LINKER ARM FOR SOLID SUPPORT OLIGONUCLEOTIDE SYNTHESIS AND PROCESS FOR PRODUCTION THEREOF | UNIVERSITY TECHNOLOGIES INTERNATIONAL INC. (CA) | 1998-11-18 | — | — | EP | disclosed |
| US-5808039-A | 2'-OMe CAC phosphoramidite and methods for preparation and use thereof | BECKMAN INSTRUMENTS, INC. (US) | 1998-09-15 | — | — | US | disclosed |
| US-5736626-A | DIGLYCOLATE SYNTHESIS SUPPORTS | THE PERKIN-ELMER CORPORATION (US) | 1998-04-07 | — | — | US | disclosed |
| WO-1997036960-A1 | ASYMMETRIC BENZOXANTHENE DYES | THE PERKIN-ELMER CORPORATION (US) | 1997-10-09 | — | — | WO | disclosed |
| EP-0786468-A2 | Solid support reagents for the direct synthesis of 3'-labeled polynucleotides | THE PERKIN-ELMER CORPORATION (US) | 1997-07-30 | — | — | EP | disclosed |
| WO-1997023497-A1 | LINKER ARM FOR SOLID SUPPORT OLIGONUCLEOTIDE SYNTHESIS AND PROCESS FOR PRODUCTION THEREOF | UNIVERSITY TECHNOLOGIES INTERNATIONAL INC. (CA) | 1997-07-03 | — | — | WO | disclosed |
| US-5569769-A | Preparation of pyrazole and its derivatives | BASF AKTIENGESELLSCHAFT (DE) | 1996-10-29 | — | — | US | disclosed |
| JP-H01156963-A | PRODUCTION OF 1-SUBSTITUTED 5-AMINOPYRAZOLE | UBE IND LTD | 1989-06-20 | — | — | JP | disclosed |
| US-4013658-A | SYNTHESIS OF 3,5-DIPHENYL-4(1H)-PYRIDAZINONES | ELI LILLY AND COMPANY (US) | 1977-03-22 | — | — | US | disclosed |
| US-4013658-A | SYNTHESIS OF 3,5-DIPHENYL-4(1H)-PYRIDAZINONES | ELI LILLY AND COMPANY (US) | 1977-03-22 | — | — | US | disclosed |