Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | CTSD | P07339 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | CTNNB1 | P35222 | 3/20 | 0.44 |
| ▸ | WNT3A | P56704 | 3/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | TDO2 | P48775 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | STAT3 | P40763 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL598461 | 0.76 | L3MBTL1 (0.64) | LMNASMN1; SMN2L3MBTL1ALDH1A1HTT | |
| SCHEMBL29639741 | 0.76 | L3MBTL1 (0.64) | LMNASMN1; SMN2L3MBTL1ALDH1A1HTT | |
| SCHEMBL15079925 | 0.76 | SMN1; SMN2 (0.76) | LMNASMN1; SMN2L3MBTL1ALDH1A1HTT | |
| SCHEMBL7716136 | 0.76 | NPSR1 (0.44) | SMN1; SMN2L3MBTL1ALDH1A1HTTKMT2A | |
| SCHEMBL2565533 | 0.75 | KMT2A (0.40) | LMNASMN1; SMN2L3MBTL1ALDH1A1HTT | |
| SCHEMBL6491544 | 0.75 | TDP1 (0.49) | LMNASMN1; SMN2L3MBTL1ALDH1A1KMT2A | |
| SCHEMBL11850746 | 0.75 | KMT2A (0.39) | SMN1; SMN2L3MBTL1ALDH1A1KMT2ANPC1 | |
| SCHEMBL902241 | 0.73 | ALOX15 (0.53) | LMNASMN1; SMN2L3MBTL1ALDH1A1KMT2A | |
| SCHEMBL6321424 | 0.72 | LMNA (0.71) | LMNASMN1; SMN2L3MBTL1ALDH1A1HTT | |
| SCHEMBL21128714 | 0.72 | NPC1 (0.83) | LMNASMN1; SMN2L3MBTL1ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050119332-A1 | Substituted thiophene compounds as modulators of protein tyrosine phosphatases (PTPases) | JEPPESEN LONE (DK) | 2005-06-02 | — | — | US | claimed |
| US-20050119332-A1 | Substituted thiophene compounds as modulators of protein tyrosine phosphatases (PTPases) | JEPPESEN LONE (DK) | 2005-06-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050119332-A1 | Substituted thiophene compounds as modulators of protein tyrosine phosphatases (PTPases) | PTPRCAP, PTPRS, PTPN1 | LMNA 4870/4885SMN1; SMN2 1880/4885L3MBTL1 3375/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.