Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | CES1 | P23141 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.43 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.43 |
| ▸ | FEN1 | P39748 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL902241 | 0.84 | ALOX15 (0.53) | TDP1L3MBTL1MAPTSMN1; SMN2KMT2A | |
| SCHEMBL9787031 | 0.80 | NPC1 (0.47) | TDP1L3MBTL1NPC1MAPTRAB9A | |
| SCHEMBL7472455 | 0.79 | ALDH1A1 (0.32) | L3MBTL1MAPTKMT2AMEN1ALDH1A1 | |
| SCHEMBL11850746 | 0.79 | KMT2A (0.39) | L3MBTL1NPC1RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL1803317 | 0.79 | KDM4E (0.46) | L3MBTL1MAPTSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL7476929 | 0.77 | HPGD (0.44) | TDP1L3MBTL1NPC1MAPTRAB9A | |
| SCHEMBL7048126 | 0.76 | HSD11B1 (0.35) | L3MBTL1NPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL2565533 | 0.76 | KMT2A (0.40) | L3MBTL1MAPTSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL9695964 | 0.76 | PTGDR2 (0.33) | TDP1ALDH1A1MAPK1ALOX15CYP1A2 | |
| SCHEMBL6314235 | 0.75 | LMNA (0.54) | L3MBTL1NPC1RAB9ASMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4181800-A | ANTIBIOTICS FROM SUBSTITUTED PERHYDRO-S-TRIAZINES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1980-01-01 | — | — | US | claimed |
| US-6908996-B2 | Compounds and method for preparing 3-methylcephams | IMPERIAL COLLEGE OF LONDON (GB) | 2005-06-21 | — | — | US | disclosed |
| US-20040106790-A1 | Novel compounds and method for preparing 3-methylcephams | COOPER CONSULTING | 2004-06-03 | — | — | US | disclosed |
| US-6683176-B2 | FOR USE IN PRODUCING AMINO ACID DERIVATIVE ANTIBIOTICS | COOPER CONSULTING | 2004-01-27 | — | — | US | disclosed |
| EP-1183262-A4 | INTERMEDIATES FOR AND SYNTHESIS OF 3-METHYLENE CEPHAMS | COOPER CONSULTING INC (US) | 2003-04-09 | — | — | EP | disclosed |
| US-20030036650-A1 | Intermediates for and synthesis of 3-methylene cephams | IMPERIAL COLLEGE OF LONDON (GB) | 2003-02-20 | — | — | US | disclosed |
| EP-1183262-A1 | INTERMEDIATES FOR AND SYNTHESIS OF 3-METHYLENE CEPHAMS | Cooper Consulting Inc. (US) | 2002-03-06 | — | — | EP | disclosed |
| WO-2001060828-A1 | INTERMEDIATES FOR AND SYNTHESIS OF 3-METHYLENE CEPHAMS | COOPER CONSULTING INC. (US) | 2001-08-23 | — | — | WO | disclosed |
| US-5380875-A | Purification of N-(9-fluorenylmethoxycarbonyl)-4-hydroxyproline | HITACHI CHEMICAL COMPANY, LTD. (JP) | 1995-01-10 | — | — | US | disclosed |
| US-4988662-A | MULTILAYER ELEMENT OF A COATED SUBSTRATE, A FILM WITH A COLOR-FORMING LACTONE, AN ACID AND A SENSITIZER | DAINIPPON INK AND CHEMICALS, INC. (JP) | 1991-01-29 | — | — | US | disclosed |
| EP-0019401-B1 | PROCESS FOR PREPARING ENAMINE DERIVATIVES, COMPOUNDS SO PRODUCED AND PROCESS FOR PREPARING A 3-HYDROXY-CEPHALOSPORIN | Lilly Industries Limited (GB) | 1984-03-21 | — | — | EP | disclosed |
| US-4301280-A | Preparation of 3-substituted cephalosporins | LILLY INDUSTRIES LIMITED (GB) | 1981-11-17 | — | — | US | disclosed |
| EP-0019401-A1 | Process for preparing enamine derivatives, compounds so produced and process for preparing a 3-hydroxy-cephalosporin | Lilly Industries Limited (GB) | 1980-11-26 | — | — | EP | disclosed |
| US-4176231-A | Process for preparing 3-exomethylenecepham sulfoxides | LILLY INDUSTRIES LIMITED (GB) | 1979-11-27 | — | — | US | disclosed |
| US-4159266-A | AZETIDINONE SULFINIC ACID DERIVATIVES | ELI LILLY AND COMPANY (US) | 1979-06-26 | — | — | US | disclosed |
| US-4052387-A | METHOD OF PREPARATION OF 3-METHYLENECEPHAMS | ELI LILLY AND COMPANY (US) | 1977-10-04 | — | — | US | disclosed |
| US-4048163-A | Process for preparation of 7-alkoxy-3-chloromethylcephems | ELI LILLY AND COMPANY (US) | 1977-09-13 | — | — | US | disclosed |
| US-4048160-A | Process for preparation of 7-alkoxy-3-bromomethylcephems | ELI LILLY AND COMPANY (US) | 1977-09-13 | — | — | US | disclosed |
| US-4042585-A | Process for preparation of 3-halomethylcephems | ELI LILLY AND COMPANY (US) | 1977-08-16 | — | — | US | disclosed |
| US-4038275-A | PROCESS FOR PREPARATION OF 3-HYDROXYMETHYLCEPHEMS | ELI LILLY AND COMPANY (US) | 1977-07-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030036650-A1 | Intermediates for and synthesis of 3-methylene cephams | LSS, DHPS, COASY | TDP1 4456/4885L3MBTL1 2255/4885NPC1 2026/4885 |
| US-20040106790-A1 | Novel compounds and method for preparing 3-methylcephams | DHPS, FDPS, COASY | TDP1 4727/4885L3MBTL1 4697/4885NPC1 2054/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.