Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 5/20 | 0.59 |
| ▸ | NPC1 | O15118 | 4/20 | 0.54 |
| ▸ | RAB9A | P51151 | 4/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | HTR1A | P08908 | 1/20 | 0.54 |
| ▸ | DRD2 | P14416 | 1/20 | 0.54 |
| ▸ | HTR2A | P28223 | 1/20 | 0.54 |
| ▸ | HTR7 | P34969 | 1/20 | 0.54 |
| ▸ | HTR6 | P50406 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.44 |
| ▸ | RELA | Q04206 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28563755 | 0.85 | NPC1 (0.63) | NPC1RAB9ASMN1; SMN2HTR1ADRD2 | |
| SCHEMBL10916421 | 0.76 | HSP90AA1 (0.61) | HSP90AA1NPC1RAB9ASMN1; SMN2HSP90AB1 | |
| SCHEMBL6315157 | 0.76 | HSP90AA1 (0.60) | HSP90AA1HSP90AB1ADORA2AADORA1 | |
| SCHEMBL6315250 | 0.74 | NPC1 (0.71) | HSP90AA1NPC1RAB9ASMN1; SMN2HTR1A | |
| SCHEMBL6309423 | 0.74 | HSP90AA1 (0.57) | HSP90AA1HTR2AHSP90AB1ADORA2AADORA1 | |
| SCHEMBL6307180 | 0.74 | HSP90AA1 (0.57) | HSP90AA1RAB9ASMN1; SMN2HSP90AB1ADORA2A | |
| SCHEMBL6315112 | 0.70 | HSP90AA1 (0.52) | HSP90AA1RAB9ASMN1; SMN2HSP90AB1ADORA2A | |
| SCHEMBL4093530 | 0.68 | HSP90AA1 (1.00) | HSP90AA1NPC1RAB9AKMT2AHSP90AB1 | |
| SCHEMBL24022696 | 0.68 | KDM4E (0.59) | HSP90AA1NPC1RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL2117682 | 0.67 | L3MBTL1 (0.46) | NPC1RAB9ASMN1; SMN2HTR1ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6919339-B2 | ABCA-1 elevating compounds | CV THEAPEUTICS, INC. (US) | 2005-07-19 | — | — | US | disclosed |
| US-20020128266-A1 | ABCA-1 elevating compounds | CV THERAPEUTICS, INC. | 2002-09-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020128266-A1 | ABCA-1 elevating compounds | ABCD3, ABCE1, ABCB4 | HSP90AA1 1676/4885NPC1 6/4885RAB9A 2138/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.