Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | VDR | P11473 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Water SCHEMBL16927693 | 0.98 | KMT2A (0.49) | KMT2AMEN1VDRSMN1; SMN2PKM | |
| SCHEMBL2531424 | 0.98 | VDR (0.51) | KMT2AMEN1VDRSMN1; SMN2PKM | |
| SCHEMBL28290954 | 0.95 | PKM (0.53) | KMT2AMEN1VDRSMN1; SMN2PKM | |
| SCHEMBL5185491 | 0.91 | VDR (0.54) | KMT2AMEN1VDRSMN1; SMN2PKM | |
| SCHEMBL8217662 | 0.84 | CYP2D6 (0.52) | KMT2AVDRPKMALDH1A1POLB | |
| SCHEMBL890525 | 0.83 | USP2 (0.48) | KMT2AMEN1VDRSMN1; SMN2PKM | |
| SCHEMBL3739465 | 0.83 | VDR (0.51) | KMT2AMEN1VDRSMN1; SMN2PKM | |
| SCHEMBL5875363 | 0.83 | VDR (0.47) | VDRPKMALDH1A1POLBHTT | |
| SCHEMBL40765 | 0.81 | VDR (0.46) | VDRPKMALDH1A1POLBHTT | |
| SCHEMBL15006565 | 0.81 | VDR (0.46) | KMT2AMEN1VDRPKMALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 193 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2240466-A1 | PHARMACEUTICALLY ACCEPTABLE SALTS OF 2-{4-[(3S)-PIPERIDIN-3- YL]PHENYL} -2H-INDAZOLE-7-CARBOXAMIDE | Merck Sharp & Dohme Limited (GB) | 2010-10-20 | — | — | EP | claimed |
| WO-2009087381-A1 | PHARMACEUTICALLY ACCEPTABLE SALTS OF 2-{4-[(3S)-PIPERIDIN-3- YL]PHENYL} -2H-INDAZOLE-7-CARBOXAMIDE | MERCK SHARP & DOHME LTD (GB) | 2009-07-16 | — | — | WO | claimed |
| US-3988159-A | Light-sensitive material containing nitrone for forming heat-fixed images | AMERICAN CAN COMPANY (US) | 1976-10-26 | — | — | US | claimed |
| EP-4479050-A1 | USE OF NIRAPARIB FOR THE TREATMENT OF BRAIN CANCER | Tesaro, Inc. (US) | 2024-12-25 | — | — | EP | disclosed |
| WO-2023159066-A1 | USE OF NIRAPARIB FOR THE TREATMENT OF BRAIN CANCER | TESARO, INC. (US) | 2023-08-24 | — | — | WO | disclosed |
| US-20230183222-A1 | 8-Amino-2-Oxo-1,3-Diaza-Spiro-[4.5]-Decane Derivatives | GRUENENTHAL GMBH (DE) | 2023-06-15 | — | — | US | disclosed |
| EP-2420891-B1 | Process for immersion lithography | ROHM & HAAS ELECT MAT (US) | 2021-06-23 | — | — | EP | disclosed |
| US-20210179595-A1 | 8-Amino-2-Oxo-1,3-Diaza-Spiro-[4.5]-Decane Derivatives | Grünenthal GmbH (DE) | 2021-06-17 | — | — | US | disclosed |
| US-10809616-B2 | Cholate photoacid generators and photoresists comprising same | ROHM AND HAAS ELECTRONIC MATERIALS LLC (US) | 2020-10-20 | — | — | US | disclosed |
| US-10793556-B2 | 8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives | GRUENENTHAL GMBH (DE) | 2020-10-06 | — | — | US | disclosed |
| US-20200222352-A1 | FORMULATIONS AND USES OF RETINOIC ACID RECEPTOR SELECTIVE AGONISTS | QURETINO THERAPEUTICS, INC. | 2020-07-16 | — | — | US | disclosed |
| WO-2001009076-A2 | RETINOIDS FOR THE TREATMENT OF EMPHYSEMA | F. HOFFMANN-LA ROCHE AG (CH) | 2001-02-08 | — | — | WO | disclosed |
| WO-2000010056-A9 | PHOTOACID GENERATORS AND PHOTORESISTS COMPRISING SAME | SHIPLEY CO LLC (US) | 2000-06-08 | — | — | WO | disclosed |
| US-6048672-A | RELIEF IMAGES ON SUBSTRATES WITH TITANIUM NITRIDE SURFACES, HEATING, COATING, EXPOSURE AND DEVELOPMENT | SHIPLEY COMPANY, L.L.C. (US) | 2000-04-11 | — | — | US | disclosed |
| US-6037107-A | EXPOSING TO ACTIVATION RADIATION A POSITIVE WORKING PHOTORESIST COMPRISING AN ALKALI SOLUBLE RESIN SUBSTITUTED WITH AN ACID LABILE BLOCKING GROUP TO GENERATE HALOGENATED SULFONIC ACID BY PHOTOLYSIS | SHIPLEY COMPANY, L.L.C. (US) | 2000-03-14 | — | — | US | disclosed |
| WO-2000010056-A1 | PHOTOACID GENERATORS AND PHOTORESISTS COMPRISING SAME | SHIPLEY COMPANY, L.L.C. (US) | 2000-02-24 | — | — | WO | disclosed |
| EP-0938029-A2 | Methods using photoresist compositions and articles produced therewith | Shipley Company LLC (US) | 1999-08-25 | — | — | EP | disclosed |
| EP-0666856-A1 | 4-ARYLMETHYLOXYMETHYL PIPERIDINES AS TACHYKININ ANTAGONISTS | MERCK SHARP & DOHME LTD. (GB) | 1995-08-16 | — | — | EP | disclosed |
| US-4343891-A | CONVERTING TO COMPOUND HAVING FEWER THAN FOUR CARBON-TO-BORON BONDS | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1982-08-10 | — | — | US | disclosed |
| US-3988159-A | Light-sensitive material containing nitrone for forming heat-fixed images | AMERICAN CAN COMPANY (US) | 1976-10-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210179595-A1 | 8-Amino-2-Oxo-1,3-Diaza-Spiro-[4.5]-Decane Derivatives | OPRK1, OPRD1, OPRL1 | KMT2A 2401/4885MEN1 3826/4885VDR 78/4885 |
| US-10809616-B2 | Cholate photoacid generators and photoresists comprising same | GGCT, LCAT, SLC7A11 | KMT2A 2499/4885MEN1 1307/4885VDR 1408/4885 |
| US-20200222352-A1 | FORMULATIONS AND USES OF RETINOIC ACID RECEPTOR SELECTIVE AGONISTS | RARA, RARB, RARG | KMT2A 3088/4885MEN1 4260/4885VDR 8/4885 |
| US-10793556-B2 | 8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives | OPRK1, OPRD1, OPRL1 | KMT2A 2401/4885MEN1 3826/4885VDR 78/4885 |
| US-20230183222-A1 | 8-Amino-2-Oxo-1,3-Diaza-Spiro-[4.5]-Decane Derivatives | OPRK1, OPRD1, OPRL1 | KMT2A 2401/4885MEN1 3826/4885VDR 78/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.