Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACLY | P53396 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 3/20 | 0.39 |
| ▸ | CNR2 | P34972 | 2/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22070145 | 0.74 | KDM4E (0.46) | ALDH1A1KDM4EHPGDHSD17B10GLA | |
| SCHEMBL10467315 | 0.72 | ALDH1A1 (0.43) | ALDH1A1KDM4EHPGDHSD17B10GLA | |
| SCHEMBL631892 | 0.72 | KDM4E (0.53) | ACLYALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL11578980 | 0.70 | ADAMTS4 (0.59) | ALDH1A1HPGDHSD17B10HTTCA14 | |
| SCHEMBL20050622 | 0.70 | KDM4E (0.50) | ACLYALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL631543 | 0.69 | KDM4E (0.49) | ACLYALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL25269775 | 0.66 | TSHR (0.58) | ALDH1A1KDM4EHPGDHSD17B10CYP2C19 | |
| SCHEMBL7138463 | 0.66 | TSHR (0.58) | ALDH1A1KDM4EHPGDHSD17B10CYP2C19 | |
| SCHEMBL7889040 | 0.66 | TSHR (0.58) | ALDH1A1KDM4EHPGDHSD17B10CYP2C19 | |
| SCHEMBL15987388 | 0.66 | SRC (0.56) | ALDH1A1KDM4EHPGDHSD17B10GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2420489-B1 | Indolesulfonyl protecting groups for protection of guanidino and amino groups | LONZA AG (CH) | 2014-04-23 | — | — | EP | disclosed |
| US-8431720-B2 | Indolesulfonyl protecting groups for protection of guanidino and amino groups | LONZA LTD. (CH) | 2013-04-30 | — | — | US | disclosed |
| EP-2420489-A1 | Indolesulfonyl protecting groups for protection of guanidino and amino groups | Lonza Ltd (CH) | 2012-02-22 | — | — | EP | disclosed |
| US-20110060125-A1 | INDOLESULFONYL PROTECTING GROUPS FOR PROTECTION OF GUANIDINO AND AMINO GROUPS | POLYPEPTIDE LABORATORIES HOLDING (PPL) AB (SE) | 2011-03-10 | — | — | US | disclosed |
| EP-2280942-A1 | INDOLESULFONYL PROTECTING GROUPS FOR PROTECTION OF GUANIDINO AND AMINO GROUPS | Lonza Ltd. (CH) | 2011-02-09 | — | — | EP | disclosed |
| WO-2009135645-A1 | INDOLESULFONYL PROTECTING GROUPS FOR PROTECTION OF GUANIDINO AND AMINO GROUPS | LONZA LTD (CH) | 2009-11-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110060125-A1 | INDOLESULFONYL PROTECTING GROUPS FOR PROTECTION OF GUANIDINO AND AMINO GROUPS | INMT, IDO1, IDO2 | ACLY 3993/4885ALDH1A1 1372/4885KDM4E 399/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.