Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | GLA | P06280 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | ACLY | P53396 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | GPR3 | P46089 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | NQO2 | P16083 | 1/20 | 0.43 |
| ▸ | SRC | P12931 | 3/20 | 0.42 |
| ▸ | EGFR | P00533 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | APEX1 | P27695 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pyridine SCHEMBL632139 | 0.89 | ACLY (0.45) | KDM4EALDH1A1HPGDHSD17B10GAA | |
| SCHEMBL20050622 | 0.84 | KDM4E (0.50) | KDM4EALDH1A1HPGDHSD17B10GAA | |
| SCHEMBL631543 | 0.82 | KDM4E (0.49) | KDM4EALDH1A1HPGDHSD17B10GAA | |
| SCHEMBL11321983 | 0.79 | KDM4E (0.43) | KDM4EALDH1A1HPGDHSD17B10HTT | |
| SCHEMBL7819876 | 0.78 | ALDH1A1 (0.56) | KDM4EALDH1A1HPGDHSD17B10GAA | |
| SCHEMBL11330268 | 0.78 | ALDH1A1 (0.50) | KDM4EALDH1A1HPGDHSD17B10CYP2C19 | |
| SCHEMBL11339416 | 0.78 | ALDH1A1 (0.58) | KDM4EALDH1A1HPGDHSD17B10CYP2C19 | |
| SCHEMBL27597589 | 0.77 | KDM4E (0.39) | KDM4EALDH1A1HPGDHSD17B10GAA | |
| SCHEMBL11517081 | 0.73 | CNR1 (0.38) | KDM4EALDH1A1HTTTDP1KMT2A | |
| SCHEMBL11517395 | 0.73 | HTR6 (0.43) | KDM4EALDH1A1TDP1POLBAPEX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10407389-B2 | Method for the preparation of H-Arg(MIS)-OH | POLYPEPTIDE LABORATORIES HOLDING (PPL) AB (SE) | 2019-09-10 | — | — | US | disclosed |
| US-20190241517-A1 | Method for the Preparation of H-Arg(MIS)-OH | POLYPEPTIDE LABORATORIES HOLDING PPL AB (SE) | 2019-08-08 | — | — | US | disclosed |
| EP-3315490-A1 | METHOD FOR THE PREPARATION OF H-ARG(MIS)-OH | Polypeptide Laboratories Holding (PPL) AB (SE) | 2018-05-02 | — | — | EP | disclosed |
| WO-2018064829-A1 | METHOD FOR THE PREPARATION OF H-ARG (MIS) -OH | POLYPEPTIDE LABORATORIES HOLDING (PPL) AB (SE) | 2018-04-12 | — | — | WO | disclosed |
| EP-3305780-A1 | METHOD FOR THE PREPARATION OF H-ARG(MIS)-OH | Lonza Ltd (CH) | 2018-04-11 | — | — | EP | disclosed |
| EP-2420489-B1 | Indolesulfonyl protecting groups for protection of guanidino and amino groups | LONZA AG (CH) | 2014-04-23 | — | — | EP | disclosed |
| CN-101578265-B | Sulfonamide derivatives as chymase inhibitors | HOFFMANN LA ROCHE | 2013-05-08 | — | — | CN | disclosed |
| US-8431720-B2 | Indolesulfonyl protecting groups for protection of guanidino and amino groups | LONZA LTD. (CH) | 2013-04-30 | — | — | US | disclosed |
| EP-2420489-A1 | Indolesulfonyl protecting groups for protection of guanidino and amino groups | Lonza Ltd (CH) | 2012-02-22 | — | — | EP | disclosed |
| CN-102026971-A | Indolesulfonyl protecting groups for protection of guanidino and amino groups | LONZA AG | 2011-04-20 | — | — | CN | disclosed |
| US-20110060125-A1 | INDOLESULFONYL PROTECTING GROUPS FOR PROTECTION OF GUANIDINO AND AMINO GROUPS | POLYPEPTIDE LABORATORIES HOLDING (PPL) AB (SE) | 2011-03-10 | — | — | US | disclosed |
| CN-101578265-A | Sulfonamide derivatives as chymase inhibitors | HOFFMANN LA ROCHE (CH) | 2009-11-11 | — | — | CN | disclosed |
| US-4243584-A | Monoazo dyestuffs containing diazo component substituted by disulfimide and trifluoromethyl groups | BAYER AKTIENGESELLSCHAFT (DE) | 1981-01-06 | — | — | US | disclosed |
| US-4159265-A | Phenylazopyrazolo dyestuffs including disulfimide substituent | BAYER AKTIENGESELLSCHAFT (DE) | 1979-06-26 | — | — | US | disclosed |
| US-4000123-A | POLYAMIDES | BAYER AKTIENGESELLSCHAFT (DT) | 1976-12-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10407389-B2 | Method for the preparation of H-Arg(MIS)-OH | ARG1, HNMT, PRMT3 | KDM4E 2232/4885ALDH1A1 2269/4885HPGD 327/4885 |
| US-20110060125-A1 | INDOLESULFONYL PROTECTING GROUPS FOR PROTECTION OF GUANIDINO AND AMINO GROUPS | INMT, IDO1, IDO2 | KDM4E 399/4885ALDH1A1 1372/4885HPGD 1944/4885 |
| US-20190241517-A1 | Method for the Preparation of H-Arg(MIS)-OH | ARG1, HNMT, PRMT3 | KDM4E 2232/4885ALDH1A1 2269/4885HPGD 327/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.