Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.68 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.62 |
| ▸ | MEN1 | O00255 | 5/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | MAPT | P10636 | 3/20 | 0.59 |
| ▸ | NPC1 | O15118 | 2/20 | 0.57 |
| ▸ | RAB9A | P51151 | 2/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | RECQL | P46063 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL863168 | 0.94 | MEN1 (0.69) | ALDH1A1L3MBTL1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL14563219 | 0.89 | MEN1 (0.62) | ALDH1A1L3MBTL1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL6305740 | 0.86 | SMN1; SMN2 (0.67) | ALDH1A1KMT2AMEN1SMN1; SMN2LMNA | |
| SCHEMBL17477113 | 0.84 | KMT2A (0.57) | ALDH1A1L3MBTL1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL2337244 | 0.84 | CA1 (0.70) | ALDH1A1L3MBTL1KMT2AMEN1LMNA | |
| SCHEMBL3468387 | 0.84 | MAPT (0.68) | ALDH1A1L3MBTL1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL17477155 | 0.83 | ALDH1A1 (0.72) | ALDH1A1KMT2AMEN1SMN1; SMN2LMNA | |
| SCHEMBL10565877 | 0.82 | KMT2A (0.60) | ALDH1A1L3MBTL1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL18103151 | 0.81 | ALDH1A1 (0.68) | ALDH1A1L3MBTL1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL24347611 | 0.81 | ALDH1A1 (0.80) | ALDH1A1L3MBTL1KMT2AMEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050124664-A1 | Urea thiadiazole inhibitors of plasminogen activator inhibior-1 | BRISTOL-MYERS SQUIBB CO. | 2005-06-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050124664-A1 | Urea thiadiazole inhibitors of plasminogen activator inhibior-1 | SERPINE1, SERPINC1, SERPINB1 | ALDH1A1 155/4885L3MBTL1 2991/4885KMT2A 4128/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.