Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.44 |
| ▸ | USP2 | O75604 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 6/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.43 |
| ▸ | RPS6KB1 | P23443 | 4/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.43 |
| ▸ | PDE5A | O76074 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6324691 | 0.83 | AURKA (0.48) | MAPK1ALDH1A1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL8304320 | 0.83 | ALDH1A1 (0.49) | MAPK1ALDH1A1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL6329487 | 0.82 | AURKA (0.43) | MAPK1ALDH1A1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL6322361 | 0.80 | AURKA (0.49) | POLBLMNAHPGDAURKAAURKB | |
| SCHEMBL6325892 | 0.79 | F10 (0.48) | POLBLMNAHPGDAURKAAURKB | |
| SCHEMBL8307208 | 0.79 | F10 (0.48) | POLBLMNAHPGDAURKAAURKB | |
| SCHEMBL6322321 | 0.79 | AURKA (0.42) | AURKAAURKBRPS6KB1PDE5ACNR1 | |
| Hydrochloric Acid SCHEMBL6325502 | 0.78 | F10 (0.47) | POLBLMNAHPGDAURKAAURKB | |
| SCHEMBL6329960 | 0.78 | F10 (0.48) | MAPK1AURKAAURKBRPS6KB1PDE5A | |
| Hydrochloric Acid SCHEMBL6326766 | 0.77 | F10 (0.48) | MAPK1AURKAAURKBRPS6KB1PDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050107409-A1 | Aromatic bicyclic compounds, preparation thereof and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2005-05-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050107409-A1 | Aromatic bicyclic compounds, preparation thereof and their use as pharmaceutical compositions | F12, F2, F11 | POLB 3545/4885MAPK1 2554/4885ALDH1A1 1078/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.