Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 13/20 | 0.39 |
| ▸ | IGF1R | P08069 | 9/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | ROS1 | P08922 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL4118677 | 0.84 | ACHE (0.45) | ALKIGF1RACHEBACE1KMT2A | |
| Maleic Acid SCHEMBL4118674 | 0.84 | ACHE (0.45) | ALKIGF1RACHEBACE1KMT2A | |
| Hydrochloric Acid SCHEMBL6326444 | 0.79 | CHEK1 (0.34) | ACHEBACE1 | |
| SCHEMBL13800060 | 0.79 | TP53 (0.48) | ALKIGF1RACHEBACE1ROS1 | |
| Fumaric Acid SCHEMBL6328236 | 0.79 | THRB (0.44) | ALKIGF1RACHEBACE1KMT2A | |
| Hydrochloric Acid SCHEMBL6321579 | 0.77 | ZAP70 (0.31) | — | |
| SCHEMBL6322182 | 0.77 | PDCD1 (0.39) | KMT2A | |
| SCHEMBL6168415 | 0.75 | ALDH1A1 (0.55) | ALKIGF1RACHEBACE1ROS1 | |
| SCHEMBL6320777 | 0.72 | ALDH1A1 (0.48) | KMT2A | |
| Hydrochloric Acid SCHEMBL6319371 | 0.72 | MAP3K11 (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050176764-A1 | Medicine for treating cancer | KOWA CO., LTD (JP) | 2005-08-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050176764-A1 | Medicine for treating cancer | HDAC4, HDAC3, NR4A3 | ALK 1859/4885IGF1R 689/4885ACHE 4596/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.