Boxidine

Boxidine

SCHEMBL633445

FC(F)(F)c1ccc(-c2ccc(OCCN3CCCC3)cc2)cc1

nearest known ligand 0.83

Full drug profile on Sugi Atlas →

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
LTA4H P09960 7/20 0.83
HRH3 Q9Y5N1 5/20 0.68
KDM4E B2RXH2 1/20 0.66
PSMB1 P20618 3/20 0.64
PSMB5 P28074 3/20 0.64
PSMB2 P49721 3/20 0.64
MEN1 O00255 1/20 0.59
KMT2A Q03164 1/20 0.59
KCNH2 Q12809 1/20 0.59
MCHR1 Q99705 1/20 0.59
PTGS2 P35354 1/20 0.58
DRD2 P14416 1/20 0.56
HRH1 P35367 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14970712 0.94 LTA4H (0.88) LTA4HHRH3KDM4EPSMB1PSMB5
Hydrochloric Acid SCHEMBL14966268 0.92 LTA4H (0.86) LTA4HHRH3KDM4EPSMB1PSMB5
SCHEMBL12439972 0.89 LTA4H (0.67) LTA4HHRH3KDM4EPSMB1PSMB5
SCHEMBL2323902 0.84 MCHR1 (0.75) LTA4HMCHR1
SCHEMBL4174980 0.83 LTA4H (0.71) LTA4HHRH3KDM4EPSMB1PSMB5
SCHEMBL24529993 0.82 LTA4H (0.69) LTA4HHRH3KDM4EPSMB1PSMB5
SCHEMBL1385417 0.81 LTA4H (0.79) LTA4HHRH3PSMB1PSMB5PSMB2
SCHEMBL1899201 0.81 LTA4H (1.00) LTA4HHRH3KCNH2HRH1
SCHEMBL7139384 0.81 LTA4H (1.00) LTA4HKDM4EPSMB1PSMB5PSMB2
SCHEMBL19716249 0.80 PSMB1 (0.97) LTA4HHRH3KDM4EPSMB1PSMB5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 223 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230414575-A1 MK2 ACTIVATING COMPOUNDS FOR USE IN TREATING VASCULAR LEAK AND ENDOTHELIAL BARRIER DISORDERS AKTTYVA THERAPEUTICS INC (US) 2023-12-28 US claimed
EP-4244341-A2 MK2 ACTIVATING COMPOUNDS FOR USE IN TREATING VASCULAR LEAK AND ENDOTHELIAL BARRIER DISORDERS Akttyva Therapeutics, Inc. (US) 2023-09-20 EP claimed
WO-2022104097-A2 MK2 ACTIVATING COMPOUNDS FOR USE IN TREATING VASCULAR LEAK AND ENDOTHELIAL BARRIER DISORDERS AKTTYVA THERAPEUTICS, INC. (US) 2022-05-19 WO claimed
CN-106810485-A A kind of Preparation Method And Their Intermediate of chiral boxidine alkanone 上海现代制药股份有限公司 2017-06-09 CN claimed
US-9016221-B2 Surface topographies for non-toxic bioadhesion control UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2015-04-28 US claimed
US-8268352-B2 Modified release composition for highly soluble drugs TORRENT PHARMACEUTICALS LIMITED (IN) 2012-09-18 US claimed
US-8263125-B2 Dosage form for high dose-high solubility active ingredients that provides for immediate release and modified release of the active ingredients TORRENT PHARMACEUTICALS LIMITED (IN) 2012-09-11 US claimed
US-20100226943-A1 SURFACE TOPOGRAPHIES FOR NON-TOXIC BIOADHESION CONTROL UNIVERSITY OF FLORIDA (US) 2010-09-09 US claimed
CN-101330905-A Freeze-drying process and products obtained thereby SCIDOSE LLC (US) 2008-12-24 CN claimed
EP-1954244-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY Scidose, Llc (US) 2008-08-13 EP claimed
WO-2007061529-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY SCIDOSE LLC. (US) 2007-05-31 WO claimed
US-20070116729-A1 Lyophilization process and products obtained thereby SCIDOSE LLC 2007-05-24 US claimed
US-20060024365-A1 Novel dosage form VAYA NAVIN 2006-02-02 US claimed
US-20060018933-A1 Novel drug delivery system TORRENT PHARMACEUTICALS LIMITED (IN) 2006-01-26 US claimed
US-20060018934-A1 Novel drug delivery system TORRENT PHARMACEUTICALS LIMITED (IN) 2006-01-26 US claimed
EP-4706683-A2 CHEWABLE FORMULATIONS Elanco Tiergesundheit AG (CH) 2026-03-11 EP disclosed
US-20260034059-A1 ORAL FILM COMPOSITIONS AND DOSAGE FORMS HAVING PRECISE ACTIVE DISSOLUTION PROFILES AQUESTIVE THERAPEUTICS, INC. (US) 2026-02-05 US disclosed
EP-0909183-A2 DHA-PHARMACEUTICAL AGENT CONJUGATES Neuromedica, Inc. (US) 1999-04-21 EP disclosed
US-5795909-A ANTICARCINOGENIC AND ANTITUMOR AGENTS; BREAST, COLON, OVARIANCANCERS NEUROMEDICA, INC. (US) 1998-08-18 US disclosed
WO-1997044063-A2 DHA-PHARMACEUTICAL AGENT CONJUGATES NEUROMEDICA, INC. (US) 1997-11-27 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260034059-A1 ORAL FILM COMPOSITIONS AND DOSAGE FORMS HAVING PRECISE ACTIVE DISSOLUTION PROFILES SORD, SLC6A13, CACNA1A LTA4H 3054/4885HRH3 883/4885KDM4E 1515/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.