Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 14/20 | 0.77 |
| ▸ | RAB9A | P51151 | 13/20 | 0.77 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.67 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.67 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.67 |
| ▸ | RELA | Q04206 | 1/20 | 0.67 |
| ▸ | LMNA | P02545 | 1/20 | 0.67 |
| ▸ | TP53 | P04637 | 2/20 | 0.62 |
| ▸ | GAA | P10253 | 1/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | TOP1 | P11387 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14642683 | 0.84 | NPC1 (0.72) | NPC1RAB9ASMN1; SMN2ALDH1A1NFKB1 | |
| SCHEMBL13657955 | 0.82 | NPC1 (0.74) | NPC1RAB9ASMN1; SMN2ALDH1A1NFKB1 | |
| SCHEMBL11345273 | 0.82 | NPC1 (0.73) | NPC1RAB9ASMN1; SMN2ALDH1A1NFKB1 | |
| SCHEMBL6232715 | 0.79 | NPC1 (1.00) | NPC1RAB9ASMN1; SMN2ALDH1A1NFKB1 | |
| SCHEMBL6338058 | 0.75 | POLB (0.54) | NPC1RAB9ASMN1; SMN2ALDH1A1NFKB1 | |
| SCHEMBL11343599 | 0.73 | RAB9A (0.79) | NPC1RAB9ASMN1; SMN2ALDH1A1NFKB1 | |
| SCHEMBL9035260 | 0.71 | NPC1 (0.67) | NPC1RAB9ASMN1; SMN2ALDH1A1NFKB1 | |
| SCHEMBL11352738 | 0.71 | ALDH1A1 (0.67) | NPC1RAB9ASMN1; SMN2ALDH1A1NFKB1 | |
| SCHEMBL13062806 | 0.71 | NPC1 (0.70) | NPC1RAB9ASMN1; SMN2ALDH1A1NFKB1 | |
| SCHEMBL8660366 | 0.70 | NPC1 (0.83) | NPC1RAB9ASMN1; SMN2ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6900219-B2 | ABCA-1 elevating compounds | CV THERAPEUTICS, INC. (US) | 2005-05-31 | — | — | US | disclosed |
| US-20030220356-A1 | ABCA-1 elevating compounds | CV THERAPEUTICS, INC. | 2003-11-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030220356-A1 | ABCA-1 elevating compounds | ABCD3, ABCE1, ABCB4 | NPC1 6/4885RAB9A 2138/4885SMN1; SMN2 4558/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.