Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | THRB | P10828 | 4/20 | 0.42 |
| ▸ | RECQL | P46063 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | APEX1 | P27695 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | VDR | P11473 | 1/20 | 0.33 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.30 |
| ▸ | ALPG | P10696 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7532656 | 0.98 | MEN1 (0.40) | MEN1MAPTTHRBRECQLKMT2A | |
| SCHEMBL26782791 | 0.79 | LTA4H (0.38) | MEN1MAPTTHRBRECQLKMT2A | |
| Iodide SCHEMBL6832522 | 0.79 | MEN1 (0.42) | MEN1MAPTTHRBRECQLKMT2A | |
| SCHEMBL18745572 | 0.76 | MEN1 (0.40) | MEN1MAPTTHRBRECQLKMT2A | |
| SCHEMBL15315509 | 0.76 | MEN1 (0.40) | MEN1MAPTTHRBRECQLKMT2A | |
| SCHEMBL16696020 | 0.76 | MEN1 (0.40) | MEN1MAPTTHRBRECQLKMT2A | |
| SCHEMBL3961483 | 0.76 | TDP1 (0.40) | MEN1MAPTTHRBRECQLKMT2A | |
| SCHEMBL4615881 | 0.74 | VDR (0.58) | MEN1MAPTTHRBRECQLKMT2A | |
| Iodide SCHEMBL7033663 | 0.73 | MEN1 (0.43) | MEN1MAPTTHRBRECQLKMT2A | |
| Iodide SCHEMBL10758793 | 0.73 | MEN1 (0.40) | MEN1MAPTTHRBRECQLKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6977001-B2 | Dye compositions containing quinolinium salts | WELLA AG (DE) | 2005-12-20 | — | — | US | disclosed |
| US-6835212-B2 | Compound with a nucleophilic reaction center, aryl alcohol or benzyl alcohol derivatives and an oxidizing enzyme | WELLA AKTIENGESELLSCHAFT (DE) | 2004-12-28 | — | — | US | disclosed |
| US-6740128-B2 | BLEND CONTAINING ENAMINE AND ALKALINE MIXTURE OF ALDEHYDE AND PRIMARY AMINE | WELLA AKTIENGESELLSCHAFT (DE) | 2004-05-25 | — | — | US | disclosed |
| US-6669739-B2 | Agent for coloring fibers and method for temporarily coloring fibers | WELLA AKTIENGESELLSCHAFT (DE) | 2003-12-30 | — | — | US | disclosed |
| US-6652601-B2 | For dyeing and subsequently decolorizing fibers such as keratin fibers | WELLA AKTIENGESELLSCHAFT (DE) | 2003-11-25 | — | — | US | disclosed |
| US-20030177592-A1 | Dye compositions containing quinolinium salts | HFC PRESTIGE INTERNATIONAL HOLDING SWITZERLAND S.A.R.L (CH) | 2003-09-25 | — | — | US | disclosed |
| US-20030101520-A1 | Agent for coloring fibers | WELLA INTERNATIONAL OPERATIONS SWITZERLAND SARL (CH) | 2003-06-05 | — | — | US | disclosed |
| US-20030079301-A1 | Agent for dyeing fibers comprising an indoline/indolium derivative | WELLA INTERNATIONAL OPERATIONS SWITZERLAND SARL (CH) | 2003-05-01 | — | — | US | disclosed |
| US-20030041391-A1 | Agent and method for dyeing keratin fibres | Wella GmbH (DE) | 2003-03-06 | — | — | US | disclosed |
| US-20020172651-A1 | Agent for coloring fibers and method for temporarily coloring fibers | WELLA INTERNATIONAL OPERATIONS SWITZERLAND SARL (CH) | 2002-11-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030079301-A1 | Agent for dyeing fibers comprising an indoline/indolium derivative | IDO1, IDO2, KIT | MEN1 1860/4885MAPT 1104/4885THRB 4443/4885 |
| US-20030101520-A1 | Agent for coloring fibers | COL1A1, ENO1, H1-5 | MEN1 996/4885MAPT 960/4885THRB 4522/4885 |
| US-20020172651-A1 | Agent for coloring fibers and method for temporarily coloring fibers | ENO1, H1-5, H1-2 | MEN1 1144/4885MAPT 1635/4885THRB 4482/4885 |
| US-20030041391-A1 | Agent and method for dyeing keratin fibres | KRT18, AKR7A2, ADH5 | MEN1 4837/4885MAPT 844/4885THRB 4463/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.