Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxymorphone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 9/20 | 0.68 |
| ▸ | OPRD1 known ✓ | P41143 | 8/20 | 0.68 |
| ▸ | OPRK1 known ✓ | P41145 | 7/20 | 0.68 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.58 |
| ▸ | MRGPRX2 | Q96LB1 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | BLM | P54132 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxycodone SCHEMBL28142074 | 0.97 | OPRM1 (0.73) | OPRM1OPRD1OPRK1LMNAPDE4D | |
| Oxycodone SCHEMBL3407528 | 0.91 | OPRM1 (0.73) | OPRM1OPRD1OPRK1LMNAPDE4D | |
| Oxycodone SCHEMBL19285728 | 0.88 | OPRM1 (0.61) | OPRM1OPRD1OPRK1LMNAPDE4D | |
| Oxycodone SCHEMBL17165053 | 0.88 | OPRM1 (0.61) | OPRM1OPRD1OPRK1LMNAPDE4D | |
| Oxycodone SCHEMBL4222853 | 0.87 | OPRM1 (0.79) | OPRM1OPRD1OPRK1LMNAPDE4D | |
| Hydrocodone SCHEMBL1683551 | 0.87 | OPRD1 (0.77) | OPRM1OPRD1OPRK1LMNAPDE4D | |
| Dihydrocodeine SCHEMBL16105089 | 0.87 | OPRD1 (0.77) | OPRM1OPRD1OPRK1LMNAPDE4D | |
| Oxycodone SCHEMBL14320307 | 0.87 | OPRM1 (0.79) | OPRM1OPRD1OPRK1LMNAPDE4D | |
| Oxycodone SCHEMBL1029465 | 0.87 | OPRM1 (0.68) | OPRM1OPRD1OPRK1PDE4DMRGPRX2 | |
| Oxymorphone SCHEMBL1828172 | 0.87 | OPRM1 (0.68) | OPRM1OPRD1OPRK1PDE4DMRGPRX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050089568-A1 | Melt-extruded orally administrable opioid formulations | EURO-CELTIQUE S.A. | 2005-04-28 | — | — | US | claimed |