Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 10/20 | 0.65 |
| ▸ | NPC1 | O15118 | 9/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 9/20 | 0.65 |
| ▸ | HPGD | P15428 | 7/20 | 0.65 |
| ▸ | MAPT | P10636 | 4/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.65 |
| ▸ | CASP1 | P29466 | 1/20 | 0.65 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.65 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.58 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.58 |
| ▸ | RELA | Q04206 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7564852 | 0.89 | RAB9A (0.79) | RAB9ANPC1SMN1; SMN2HPGDMAPT | |
| SCHEMBL28979097 | 0.87 | RAB9A (0.63) | RAB9ANPC1SMN1; SMN2HPGDMAPT | |
| SCHEMBL1022959 | 0.84 | RAB9A (0.68) | RAB9ANPC1SMN1; SMN2HPGDMAPT | |
| SCHEMBL6004359 | 0.84 | RAB9A (0.58) | RAB9ANPC1SMN1; SMN2HPGDMAPT | |
| SCHEMBL13387589 | 0.84 | RAB9A (0.72) | RAB9ANPC1SMN1; SMN2HPGDMAPT | |
| SCHEMBL28098528 | 0.84 | RAB9A (0.63) | RAB9ANPC1SMN1; SMN2HPGDMAPT | |
| SCHEMBL2321762 | 0.83 | RAB9A (0.67) | RAB9ANPC1SMN1; SMN2HPGDMAPT | |
| SCHEMBL1699197 | 0.83 | SMN1; SMN2 (0.70) | RAB9ANPC1SMN1; SMN2HPGDMAPT | |
| SCHEMBL7564856 | 0.83 | RAB9A (0.70) | RAB9ANPC1SMN1; SMN2HPGDMAPT | |
| SCHEMBL10192215 | 0.83 | RAB9A (0.70) | RAB9ANPC1SMN1; SMN2HPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050256159-A1 | 1,4-disubstituted piperidine derivatives and their use as 11,betahsd1 inhibitors | ASTRAZENECA AB (SE) | 2005-11-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050256159-A1 | 1,4-disubstituted piperidine derivatives and their use as 11,betahsd1 inhibitors | HSD11B1, HSD3B1, P4HA1 | RAB9A 2595/4885NPC1 1661/4885SMN1; SMN2 3573/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.