Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PYGL | P06737 | 3/20 | 0.36 |
| ▸ | BCHE | P06276 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 3/20 | 0.34 |
| ▸ | CTSD | P07339 | 1/20 | 0.34 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.34 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.34 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.33 |
| ▸ | FPR2 | P25090 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6348251 | 0.88 | PYGL (0.37) | PYGLBCHEALDH1A1LMNABACE1 | |
| SCHEMBL6359323 | 0.87 | SMN1; SMN2 (0.37) | PYGLBCHEALDH1A1LMNABACE1 | |
| SCHEMBL6352185 | 0.86 | BACE1 (0.37) | PYGLBCHEALDH1A1LMNABACE1 | |
| SCHEMBL6358303 | 0.84 | HDAC3 (0.35) | PYGLALDH1A1LMNABACE1CTSD | |
| SCHEMBL6358360 | 0.83 | ALDH1A1 (0.40) | ALDH1A1FPR2POLB | |
| SCHEMBL6358371 | 0.83 | ALDH1A1 (0.40) | ALDH1A1FPR2POLB | |
| SCHEMBL6348193 | 0.73 | ABCB1 (0.32) | ALDH1A1FPR2POLB | |
| SCHEMBL6349228 | 0.72 | MEN1 (0.39) | PYGLALDH1A1LMNAPOLB | |
| SCHEMBL6349375 | 0.71 | LTA4H (0.37) | PYGLLMNA | |
| SCHEMBL6356592 | 0.71 | MEN1 (0.35) | PYGLLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6960575-B2 | For use as inhibitors of chymase | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2005-11-01 | — | — | US | disclosed |
| US-6713472-B1 | 2-OXO-1,2,3,4-TETRAHYDROPYRAZINE DERIVATIVES; CHYMASE INHIBITORS | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2004-03-30 | — | — | US | disclosed |