Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PYGL | P06737 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.35 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | BACE1 | P56817 | 4/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SLC6A11 | P48066 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6359323 | 0.89 | SMN1; SMN2 (0.37) | PYGLALDH1A1LMNAITGB3ITGA2B | |
| SCHEMBL6352185 | 0.88 | BACE1 (0.37) | PYGLALDH1A1LMNAPOLBBACE1 | |
| SCHEMBL6348190 | 0.88 | PYGL (0.36) | PYGLALDH1A1LMNAITGB3ITGA2B | |
| SCHEMBL6358303 | 0.86 | HDAC3 (0.35) | PYGLALDH1A1LMNAITGB3ITGA2B | |
| SCHEMBL6347737 | 0.82 | ALDH1A1 (0.41) | ALDH1A1LMNAPOLBKMT2AL3MBTL1 | |
| SCHEMBL6347742 | 0.82 | ALDH1A1 (0.41) | ALDH1A1LMNAPOLBKMT2AL3MBTL1 | |
| SCHEMBL6349228 | 0.73 | MEN1 (0.39) | PYGLALDH1A1LMNAPOLBKMT2A | |
| SCHEMBL6349375 | 0.72 | LTA4H (0.37) | PYGLLMNANPC1RAB9A | |
| SCHEMBL6356592 | 0.72 | MEN1 (0.35) | PYGLLMNAKMT2A | |
| SCHEMBL6348255 | 0.72 | PKM (0.33) | ALDH1A1POLBKMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6960575-B2 | For use as inhibitors of chymase | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2005-11-01 | — | — | US | disclosed |
| US-6713472-B1 | 2-OXO-1,2,3,4-TETRAHYDROPYRAZINE DERIVATIVES; CHYMASE INHIBITORS | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2004-03-30 | — | — | US | disclosed |