Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP3 | O14638 | 3/20 | 0.62 |
| ▸ | ALPL | P05186 | 3/20 | 0.62 |
| ▸ | XIAP | P98170 | 3/20 | 0.62 |
| ▸ | ELANE | P08246 | 8/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.48 |
| ▸ | F2 | P00734 | 2/20 | 0.47 |
| ▸ | PLAU | P00749 | 1/20 | 0.47 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12204829 | 0.80 | KDM4E (0.51) | ENPP3ALPLXIAPELANEMAPT | |
| Terevalefim SCHEMBL7169262 | 0.79 | ELANE (0.42) | ENPP3ALPLXIAPELANEMAPT | |
| Terevalefim SCHEMBL7169259 | 0.79 | ELANE (0.42) | ENPP3ALPLXIAPELANEMAPT | |
| SCHEMBL8511661 | 0.78 | KMT2A (0.60) | MAPTSMN1; SMN2MAPK1ALDH1A1KMT2A | |
| SCHEMBL2336029 | 0.77 | MAPT (0.59) | MAPTSMN1; SMN2MAPK1KMT2ARAB9A | |
| SCHEMBL15273732 | 0.77 | SMN1; SMN2 (0.48) | ELANEMAPTSMN1; SMN2MAPK1ALDH1A1 | |
| SCHEMBL25632856 | 0.73 | SMN1; SMN2 (0.45) | ELANESMN1; SMN2MAPK1ALDH1A1KMT2A | |
| SCHEMBL203843 | 0.73 | CA12 (0.68) | MAPTSMN1; SMN2ALDH1A1SIRT3KMT2A | |
| SCHEMBL1894879 | 0.70 | LMNA (0.52) | MAPTSMN1; SMN2ALDH1A1KMT2ARAB9A | |
| SCHEMBL2071194 | 0.70 | SMN1; SMN2 (0.57) | MAPTSMN1; SMN2MAPK1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050096372-A1 | Small-molecule modulators of hepatocyte growth factor/scatter factor activities | PILLARISETTI SIVARAM (US) | 2005-05-05 | — | — | US | disclosed |
| US-6855728-B2 | Small-molecule modulators of hepatocyte growth factor / scatter factor activities | NORTH SHORE-LONG ISLAND JEWISH HEALTH SYSTEM (US) | 2005-02-15 | — | — | US | disclosed |
| US-20030216459-A1 | Small-molecule modulators of hepatocyte growth factor / scatter factor activities | THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH | 2003-11-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030216459-A1 | Small-molecule modulators of hepatocyte growth factor / scatter factor activities | HGF, HDGF, MET | ENPP3 4055/4885ALPL 997/4885XIAP 1625/4885 |
| US-20050096372-A1 | Small-molecule modulators of hepatocyte growth factor/scatter factor activities | HGF, HDGF, MET | ENPP3 4055/4885ALPL 997/4885XIAP 1625/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.