Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11109505 | 0.88 | DRD2 (0.56) | DRD2HTR1ASIGMAR1 | |
| SCHEMBL6356804 | 0.88 | HTR1A (0.61) | DRD2HTR1ASIGMAR1 | |
| SCHEMBL6350367 | 0.88 | DRD2 (0.56) | DRD2HTR1ASIGMAR1LMNA | |
| Hydrochloric Acid SCHEMBL11101250 | 0.87 | DRD2 (0.55) | DRD2HTR1ASIGMAR1 | |
| Hydrochloric Acid SCHEMBL11105514 | 0.87 | HTR1A (0.60) | DRD2HTR1ASIGMAR1 | |
| SCHEMBL6349876 | 0.83 | DRD2 (0.52) | DRD2HTR1ASIGMAR1LMNA | |
| SCHEMBL10832670 | 0.81 | DRD2 (0.47) | DRD2HTR1A | |
| SCHEMBL11104487 | 0.81 | ADRA2A (0.56) | DRD2HTR1ASIGMAR1 | |
| SCHEMBL11107605 | 0.80 | HTR1A (0.55) | DRD2HTR1ASIGMAR1 | |
| SCHEMBL11107203 | 0.80 | ADRA2A (0.55) | DRD2HTR1ASIGMAR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1723199-A | 1,4-disubstituted piperidine derivatives and their use as 11-beta hsd1 inhibitors | ASTRAZENECA AB (SE) | 2006-01-18 | — | — | CN | disclosed |
| US-20050256159-A1 | 1,4-disubstituted piperidine derivatives and their use as 11,betahsd1 inhibitors | ASTRAZENECA AB (SE) | 2005-11-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050256159-A1 | 1,4-disubstituted piperidine derivatives and their use as 11,betahsd1 inhibitors | HSD11B1, HSD3B1, P4HA1 | DRD2 144/4885HTR1A 408/4885SIGMAR1 1024/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.