Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | TSHR | P16473 | 3/20 | 0.48 |
| ▸ | CD38 | P28907 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.43 |
| ▸ | PTGES | O14684 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6358545 | 0.86 | SMN1; SMN2 (0.49) | SMN1; SMN2ALOX15ALOX5RAB9AMEN1 | |
| SCHEMBL4044123 | 0.78 | CDK1 (0.57) | SMN1; SMN2ALOX15CDK1CCNB1ALOX5 | |
| SCHEMBL28659544 | 0.76 | MMP13 (0.57) | SMN1; SMN2TSHRALOX15RAB9AMEN1 | |
| SCHEMBL28677621 | 0.74 | MMP13 (0.59) | SMN1; SMN2TSHRALOX15RAB9AMEN1 | |
| SCHEMBL29865229 | 0.74 | IDO1 (0.58) | ALOX15CNR1CDK1CCNB1PTGES | |
| SCHEMBL28844597 | 0.74 | IDO1 (0.58) | ALOX15CNR1CDK1CCNB1PTGES | |
| SCHEMBL30525427 | 0.73 | ALOX15 (0.57) | SMN1; SMN2ALOX15CDK1CCNB1ALOX5 | |
| SCHEMBL699665 | 0.73 | ALOX15 (0.57) | SMN1; SMN2ALOX15CDK1CCNB1ALOX5 | |
| SCHEMBL7954222 | 0.73 | ALOX15 (0.57) | SMN1; SMN2ALOX15CDK1CCNB1ALOX5 | |
| SCHEMBL701020 | 0.73 | KDM4E (0.57) | SMN1; SMN2ALOX15CDK1CCNB1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6911465-B1 | Anti-inflammatory indole derivatives | ASTRAZENECA AB (SE) | 2005-06-28 | — | — | US | disclosed |
| US-20050026975-A1 | Anti-inflammatory indole derivatives | ASTRAZENECA AB (SE) | 2005-02-03 | — | — | US | disclosed |
| EP-1150954-B1 | ANTI-IMFLAMMATORY INDOLE DERIVATIVES | ASTRAZENECA AB (SE) | 2004-10-13 | — | — | EP | disclosed |
| US-6569888-B1 | Such as ethyl-N-(dichlorobenzyl)-4-(3-hydroxypropylthio) indole-2-carboxylate; for treatment of arthritis | ASTRAZENECA AB (SE) | 2003-05-27 | — | — | US | disclosed |
| EP-1159269-B1 | ANTI-IMFLAMMATORY INDOLE DERIVATIVES | ASTRAZENECA AB (SE) | 2003-03-26 | — | — | EP | disclosed |
| EP-1159269-A1 | ANTI-IMFLAMMATORY INDOLE DERIVATIVES | AstraZeneca AB (SE) | 2001-12-05 | — | — | EP | disclosed |
| EP-1150954-A1 | ANTI-IMFLAMMATORY INDOLE DERIVATIVES | AstraZeneca AB (SE) | 2001-11-07 | — | — | EP | disclosed |
| WO-2000046198-A1 | ANTI-INFLAMMATORY INDOLE DERIVATIVES | ASTRAZENECA AB (SE) | 2000-08-10 | — | — | WO | disclosed |
| WO-2000046195-A1 | ANTI-INFLAMMATORY INDOLE DERIVATIVES | ASTRAZENECA AB (SE) | 2000-08-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050026975-A1 | Anti-inflammatory indole derivatives | CCR5, CCR2, CCL5 | SMN1; SMN2 3741/4885TSHR 535/4885CD38 2929/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.