Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.49 |
| ▸ | RAB9A | P51151 | 5/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.48 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6355682 | 0.86 | SMN1; SMN2 (0.48) | SMN1; SMN2RAB9AMEN1KMT2AKDM4E | |
| SCHEMBL2004241 | 0.84 | SRD5A2 (0.56) | RAB9AMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL28659544 | 0.81 | MMP13 (0.57) | SMN1; SMN2RAB9AMEN1KMT2AKDM4E | |
| SCHEMBL7680542 | 0.79 | SRD5A2 (0.49) | SMN1; SMN2RAB9AMEN1KMT2AKDM4E | |
| SCHEMBL28677621 | 0.79 | MMP13 (0.59) | SMN1; SMN2RAB9AMEN1KMT2AKDM4E | |
| SCHEMBL700753 | 0.78 | SRD5A2 (0.73) | SMN1; SMN2RAB9AMEN1KMT2AKDM4E | |
| SCHEMBL28463263 | 0.78 | FBP1 (0.55) | RAB9AMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL701020 | 0.77 | KDM4E (0.57) | SMN1; SMN2RAB9AMEN1KMT2AKDM4E | |
| SCHEMBL27886632 | 0.77 | KDM4E (0.58) | SMN1; SMN2RAB9AMEN1KMT2AKDM4E | |
| SCHEMBL28687264 | 0.76 | HRH3 (0.54) | SMN1; SMN2RAB9AMEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6911465-B1 | Anti-inflammatory indole derivatives | ASTRAZENECA AB (SE) | 2005-06-28 | — | — | US | disclosed |
| US-20050026975-A1 | Anti-inflammatory indole derivatives | ASTRAZENECA AB (SE) | 2005-02-03 | — | — | US | disclosed |
| EP-1159269-B1 | ANTI-IMFLAMMATORY INDOLE DERIVATIVES | ASTRAZENECA AB (SE) | 2003-03-26 | — | — | EP | disclosed |
| EP-1159269-A1 | ANTI-IMFLAMMATORY INDOLE DERIVATIVES | AstraZeneca AB (SE) | 2001-12-05 | — | — | EP | disclosed |
| WO-2000046195-A1 | ANTI-INFLAMMATORY INDOLE DERIVATIVES | ASTRAZENECA AB (SE) | 2000-08-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050026975-A1 | Anti-inflammatory indole derivatives | CCR5, CCR2, CCL5 | SMN1; SMN2 3741/4885RAB9A 4335/4885MEN1 4063/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.