Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.30 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.35 |
| ▸ | HTR2A | P28223 | 2/20 | 0.32 |
| ▸ | HTR2C | P28335 | 2/20 | 0.32 |
| ▸ | HTR2B | P41595 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL27636305 | 0.72 | NR3C1 (0.32) | ADRA1A | |
| Hydrochloric Acid SCHEMBL28066485 | 0.72 | NR3C1 (0.32) | ADRA1A | |
| SCHEMBL17014295 | 0.71 | NR3C1 (0.38) | ADRA1AACHE | |
| Hydrochloric Acid SCHEMBL6142328 | 0.70 | — | — | |
| Hydrochloric Acid SCHEMBL7553845 | 0.70 | NR3C1 (0.32) | ADRA1A | |
| Hydrochloric Acid SCHEMBL29911832 | 0.70 | NR3C1 (0.32) | ADRA1A | |
| Hydrochloric Acid SCHEMBL5909810 | 0.70 | CA12 (0.34) | ADRA1AHTR2AHTR2CHTR2B | |
| Hydrochloric Acid SCHEMBL4004708 | 0.70 | ADRA1A (0.32) | ADRA1A | |
| SCHEMBL28331513 | 0.69 | NR3C1 (0.33) | ADRA1AACHE | |
| SCHEMBL27282348 | 0.69 | NR3C1 (0.33) | ADRA1AACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 97 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230137384-A1 | ARTICLE OF MANUFACTURE COMPRISING LOCAL ANESTHETIC, BUFFER, AND GLYCOSAMINOGLYCAN IN SYRINGE WITH IMPROVED STABILITY | URIGEN PHARMACEUTICALS, INC. | 2023-05-04 | — | — | US | disclosed |
| US-20210283172-A1 | ARTICLE OF MANUFACTURE COMPRISING LOCAL ANESTHETIC, BUFFER, AND GLYCOSAMINOGLYCAN IN SYRINGE WITH IMPROVED STABILITY | URIGEN PHARMACEUTICALS, INC. | 2021-09-16 | — | — | US | disclosed |
| EP-3609483-A1 | ARTICLE OF MANUFACTURE COMPRISING LOCAL ANESTHETIC, BUFFER, AND GLYCOSAMINOGLYCAN IN SYRINGE WITH IMPROVED STABILITY | Urigen Pharmaceuticals, Inc. (US) | 2020-02-19 | — | — | EP | disclosed |
| WO-2018191412-A9 | ARTICLE OF MANUFACTURE COMPRISING LOCAL ANESTHETIC, BUFFER, AND GLYCOSAMINOGLYCAN IN SYRINGE WITH IMPROVED STABILITY | URIGEN PHARMACEUTICALS, INC. (US) | 2019-05-31 | — | — | WO | disclosed |
| WO-2018191412-A1 | ARTICLE OF MANUFACTURE COMPRISING LOCAL ANESTHETIC, BUFFER, AND GLYCOSAMINOGLYCAN IN SYRINGE WITH IMPROVED STABILITY | URIGEN PHARMACEUTICALS, INC. (US) | 2018-10-18 | — | — | WO | disclosed |
| US-20050020437-A1 | Microparticulate material | MERCK PATENT GMBH (DE) | 2005-01-27 | — | — | US | disclosed |
| EP-0328348-B2 | Olefin polymerization catalyst and process for the polymerization of olefins | MITSUI CHEMICALS INC (JP) | 2004-09-15 | — | — | EP | disclosed |
| US-20040014917-A1 | Catalyst support, production and use thereof in the polymerization of olefins | MERCK PATENT GMBH (DE) | 2004-01-22 | — | — | US | disclosed |
| EP-0442725-B2 | Olefin polymerization solid catalysts and process for the polymerization of olefins | MITSUI CHEMICALS INC (JP) | 2003-10-22 | — | — | EP | disclosed |
| EP-0812862-B1 | Process for polymerizing olefins | MITSUI CHEMICALS INC (JP) | 2002-11-13 | — | — | EP | disclosed |
| EP-0327649-A1 | CATALYST FOR OLEFIN POLYMERIZATION AND PROCESS FOR ITS PREPARATION | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1989-08-16 | — | — | EP | disclosed |
| EP-0328348-A2 | Olefin polymerization catalyst and process for the polymerization of olefins | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1989-08-16 | — | — | EP | disclosed |
| EP-0324856-A1 | PROCESS FOR POLYMERIZING OLEFIN | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1989-07-26 | — | — | EP | disclosed |
| EP-0314797-A1 | OLEFIN POLYMERIZATION CATALYST AND PROCESS FOR POLYMERIZING OLEFIN | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1989-05-10 | — | — | EP | disclosed |
| EP-0295312-A1 | SOLID CATALYST FOR OLEFIN POLYMERIZATION AND PROCESS FOR ITS PREPARATION | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1988-12-21 | — | — | EP | disclosed |
| EP-0294942-A1 | Solid catalyst for polymerizing an olefin | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1988-12-14 | — | — | EP | disclosed |
| EP-0285443-A1 | Process for producing solid catalyst for polymerization of olefins | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1988-10-05 | — | — | EP | disclosed |
| EP-0283164-A2 | Cyclo-olefinic random copolymer, olefinic random copolymer, and process for producing cyclo-olefinic random copolymers | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1988-09-21 | — | — | EP | disclosed |
| EP-0279863-A1 | CATALYST FOR POLYMERIZING ALPHA-OLEFIN AND POLYMERIZATION PROCESS | MITSUI CHEMICALS, INC. (JP) | 1988-08-31 | — | — | EP | disclosed |
| EP-0279586-A2 | Finely divided aluminoxane, process for producing same and its use | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1988-08-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210283172-A1 | ARTICLE OF MANUFACTURE COMPRISING LOCAL ANESTHETIC, BUFFER, AND GLYCOSAMINOGLYCAN IN SYRINGE WITH IMPROVED STABILITY | OGFR, ALOX5, PTGS1 | ACHE 1647/4885ADRA1A 3063/4885HTR2A 2553/4885 |
| US-20230137384-A1 | ARTICLE OF MANUFACTURE COMPRISING LOCAL ANESTHETIC, BUFFER, AND GLYCOSAMINOGLYCAN IN SYRINGE WITH IMPROVED STABILITY | OGFR, ALOX5, PTGS1 | ACHE 1647/4885ADRA1A 3063/4885HTR2A 2553/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.