Teclozan

Teclozan

SCHEMBL635666

CCOCCN(Cc1ccc(CN(CCOCC)C(=O)C(Cl)Cl)cc1)C(=O)C(Cl)Cl

nearest known ligand 0.43

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.43
NAMPT P43490 1/20 0.37
KDM4E B2RXH2 2/20 0.36
SMN1; SMN2 Q16637 2/20 0.36
LMNA P02545 2/20 0.36
TSHR P16473 2/20 0.36
NPC1 O15118 1/20 0.36
ALOX15 P16050 1/20 0.36
MAPK1 P28482 1/20 0.36
HSD17B10 Q99714 1/20 0.36
YAP1 P46937 1/20 0.36
TEAD4 Q15561 1/20 0.36
TEAD2 Q15562 1/20 0.36
HDAC3 O15379 1/20 0.35
HDAC1 Q13547 1/20 0.35
HDAC2 Q92769 1/20 0.35
HDAC6 Q9UBN7 1/20 0.35
NCOR2 Q9Y618 1/20 0.35
USP2 O75604 1/20 0.35
CNR2 P34972 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11611028 0.85 NR1I2 (0.39) ALDH1A1NAMPTSMN1; SMN2TSHRHSD17B10
Etofamide SCHEMBL1163863 0.84 KCNH2 (0.46) ALDH1A1SMN1; SMN2LMNANPC1MAPK1
SCHEMBL11305706 0.81 ALDH1A1 (0.38) ALDH1A1SMN1; SMN2LMNATSHRNPC1
SCHEMBL11306582 0.80 ALDH1A1 (0.49) ALDH1A1KDM4ESMN1; SMN2LMNANPC1
SCHEMBL10598723 0.80 ALDH1A1 (0.43) ALDH1A1LMNATSHRNPC1ALOX15
SCHEMBL11305774 0.80 LMNA (0.45) SMN1; SMN2LMNATSHRNPC1ALOX15
SCHEMBL10598874 0.79 MEN1 (0.44) ALDH1A1KDM4ESMN1; SMN2LMNATSHR
SCHEMBL11591040 0.79 LMNA (0.50) ALDH1A1KDM4ELMNATSHRNPC1
SCHEMBL10428575 0.78 TSHR (0.49) ALDH1A1SMN1; SMN2TSHRHDAC1HDAC6
SCHEMBL11307932 0.78 NPC1 (0.41) ALDH1A1NAMPTSMN1; SMN2LMNATSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 510 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20170291886-A1 METHODS FOR TREATING PROTOZOAN INFECTIONS NEOCULI PTY LTD (AU) 2017-10-12 US claimed
US-9016221-B2 Surface topographies for non-toxic bioadhesion control UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2015-04-28 US claimed
US-8993117-B2 Devices with multiple surface functionality THE TRUSTEES OF PRINCETON UNIVERSITY (US) 2015-03-31 US claimed
US-8268352-B2 Modified release composition for highly soluble drugs TORRENT PHARMACEUTICALS LIMITED (IN) 2012-09-18 US claimed
US-8263125-B2 Dosage form for high dose-high solubility active ingredients that provides for immediate release and modified release of the active ingredients TORRENT PHARMACEUTICALS LIMITED (IN) 2012-09-11 US claimed
US-20120121661-A1 DEVICES WITH MULTIPLE SURFACE FUNCTIONALITY THE TRUSTEES OF PRINCETON UNIVERSITY (US) 2012-05-17 US claimed
US-20100226943-A1 SURFACE TOPOGRAPHIES FOR NON-TOXIC BIOADHESION CONTROL UNIVERSITY OF FLORIDA (US) 2010-09-09 US claimed
EP-1954244-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY Scidose, Llc (US) 2008-08-13 EP claimed
WO-2007061529-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY SCIDOSE LLC. (US) 2007-05-31 WO claimed
US-20070116729-A1 Lyophilization process and products obtained thereby SCIDOSE LLC 2007-05-24 US claimed
US-20060018933-A1 Novel drug delivery system TORRENT PHARMACEUTICALS LIMITED (IN) 2006-01-26 US claimed
US-20060018934-A1 Novel drug delivery system TORRENT PHARMACEUTICALS LIMITED (IN) 2006-01-26 US claimed
US-20050142069-A1 Buccal, polar and non-polar spray or capsule containing drugs for treating an infectious disease or cancer NOVADEL PHARMA, INC. 2005-06-30 US claimed
EP-1545458-A2 BUCCAL, POLAR OR NON-POLAR SPRAY OR CAPSULE CONTAINING DRUGS FOR TREATING AN INFECTIOUS DISEASE OR CANCER Novadel Pharma Inc. (US) 2005-06-29 EP claimed
WO-2004019912-A2 BUCCAL, POLAR OR NON-POLAR SPRAY OR CAPSULE CONTAINING DRUGS FOR TREATING AN INFECTIOUS DISEASE OR CANCER NOVADEL PHARMA INC. (US) 2004-03-11 WO claimed
US-20030082107-A1 Buccal, polar and non-polar spray or capsule containing drugs for treating an infectious disease or cancer NOVADEL PHARMA INC. 2003-05-01 US claimed
CN-1294519-A Pharmaceutical composition containing a compound having an activity of promoting the absorption of an active ingredient INPHARMA SA (CH) 2001-05-09 CN claimed
EP-1073470-A1 PHARMACEUTICAL COMPOSITIONS CONTAINING COMPOUNDS WITH ACTIVITY FOR THE ENHANCEMENT OF ABSORPTION OF ACTIVE INGREDIENTS INPHARMA S.A. (CH) 2001-02-07 EP claimed
US-6114382-A DIAGNOSING INFLAMMATORY BOWEL DISEASE(IBD) BY DETECTING PRESENCE OF MICROSPORIDIA; AND ADMINISTERING A DRUG SUCH AS TECLOZAN TO KILL LIVING MICROSPORIDIA IN THE PATIENT'S GASTROINTESTINAL TRACT; MAKING AN ANIMAL MODEL OF IBD MORETTI ITAGIBA G (BR) 2000-09-05 US claimed
WO-2000048636-A1 PHARMACEUTICAL COMPOSITIONS CONTAINING COMPOUNDS WITH ACTIVITY FOR THE ENHANCEMENT OF ABSORPTION OF ACTIVE INGREDIENTS INPHARMA S.A. (CH) 2000-08-24 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170291886-A1 METHODS FOR TREATING PROTOZOAN INFECTIONS DPM1, ABCB11, PIGS ALDH1A1 840/4885NAMPT 1911/4885KDM4E 3521/4885
US-20120121661-A1 DEVICES WITH MULTIPLE SURFACE FUNCTIONALITY PHOSPHO1, CD44, SELP ALDH1A1 2513/4885NAMPT 2211/4885KDM4E 2309/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.