Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B1 | P14061 | 3/20 | 0.34 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.34 |
| ▸ | PGR | P06401 | 2/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.31 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5727958 | 0.84 | HSD17B1 (0.38) | HSD17B1HSD17B2PGRCYP2A6ALDH1A1 | |
| SCHEMBL6992007 | 0.82 | NPC1 (0.37) | PGRALDH1A1MAPTHSD17B10RAB9A | |
| SCHEMBL144429 | 0.69 | CYP2A6 (0.45) | HSD17B1HSD17B2PGRCYP2A6ALDH1A1 | |
| SCHEMBL7615770 | 0.68 | ALDH1A1 (0.37) | ALDH1A1POLBMAPTL3MBTL1RAB9A | |
| SCHEMBL9193008 | 0.67 | CYP2A6 (0.50) | HSD17B1HSD17B2PGRCYP2A6ALDH1A1 | |
| SCHEMBL5540662 | 0.67 | CYP2A6 (0.40) | HSD17B1HSD17B2CYP2A6ALDH1A1MAPT | |
| SCHEMBL9108694 | 0.66 | PTGS1 (0.33) | — | |
| SCHEMBL8295556 | 0.64 | HSD17B1 (0.42) | HSD17B1HSD17B2PGRCYP2A6ALDH1A1 | |
| SCHEMBL128706 | 0.62 | — | — | |
| SCHEMBL6084576 | 0.62 | HSD17B1 (0.33) | HSD17B1HSD17B2CYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050256159-A1 | 1,4-disubstituted piperidine derivatives and their use as 11,betahsd1 inhibitors | ASTRAZENECA AB (SE) | 2005-11-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050256159-A1 | 1,4-disubstituted piperidine derivatives and their use as 11,betahsd1 inhibitors | HSD11B1, HSD3B1, P4HA1 | HSD17B1 5/4885HSD17B2 9/4885PGR 2858/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.