SCHEMBL6360650

SCHEMBL6360650

CSc1ccc(C(=O)Nc2ccc(C#N)cc2C(=O)O)cc1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 6/20 0.57
ALB P02768 2/20 0.55
MEN1 O00255 5/20 0.55
MAPT P10636 3/20 0.50
TDP1 Q9NUW8 2/20 0.50
ALDH1A1 P00352 1/20 0.50
HTT P42858 1/20 0.50
KCNK2 O95069 5/20 0.49
KCNK10 P57789 3/20 0.48
L3MBTL1 Q9Y468 1/20 0.47
PLK1 P53350 2/20 0.47
NR1H4 Q96RI1 1/20 0.47
CYP1A2 P05177 1/20 0.46
CYP3A4 P08684 1/20 0.46
CYP2D6 P10635 1/20 0.46
CYP2C9 P11712 1/20 0.46
CYP2C19 P33261 1/20 0.46
MCL1 Q07820 1/20 0.46
BCL2A1 Q16548 1/20 0.46
SERPINE1 P05121 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6359401 0.88 ALB (0.63) KMT2AALBMEN1MAPTTDP1
SCHEMBL6353729 0.87 PLK1 (0.54) KMT2AALBMEN1MAPTTDP1
SCHEMBL6346687 0.85 ALB (0.60) KMT2AALBMEN1MAPTTDP1
SCHEMBL6353963 0.84 KMT2A (0.62) KMT2AALBMEN1MAPTTDP1
SCHEMBL6348543 0.83 ALB (0.58) KMT2AALBMEN1MAPTTDP1
SCHEMBL6359657 0.82 MAPT (0.70) KMT2AALBMEN1MAPTTDP1
SCHEMBL6358978 0.82 ALB (0.55) KMT2AALBMEN1MAPTTDP1
SCHEMBL6349987 0.82 ALB (0.57) KMT2AALBMEN1MAPTTDP1
SCHEMBL6348677 0.82 SERPINE1 (0.66) KMT2AALBMEN1MAPTTDP1
Hydrochloric Acid SCHEMBL6834033 0.82 ALB (0.65) KMT2AALBMEN1MAPTTDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20050113450-A1 Antibacterial agents PHARMACIA & UPJOHN COMPANY 2005-05-26 US claimed
WO-2004018414-A2 ANTIBACTERIAL AGENTS PHARMACIA & UPJOHN COMPANY LLC (US) 2004-03-04 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050113450-A1 Antibacterial agents CLPP, SPOUT1, SAMHD1 KMT2A 3645/4885ALB 1682/4885MEN1 3274/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.