Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2 | P11137 | 1/20 | 0.46 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.40 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
| ▸ | NHERF1 | O14745 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4996302 | 0.79 | KDM4E (0.48) | MAP2GRIN1ALDH1A1KDM4EMEN1 | |
| SCHEMBL6356091 | 0.76 | ALDH1A1 (0.74) | MAP2ALDH1A1KDM4EGAAMEN1 | |
| SCHEMBL6353285 | 0.76 | GAA (0.72) | MAP2ALDH1A1KDM4EGAAPIN1 | |
| SCHEMBL2735911 | 0.70 | MAP2 (0.56) | MAP2ALDH1A1KDM4EGAAMEN1 | |
| SCHEMBL2735923 | 0.70 | ALDH1A1 (0.60) | MAP2ALDH1A1KDM4EGAAMEN1 | |
| SCHEMBL5738434 | 0.69 | ALDH1A1 (0.56) | MAP2ALDH1A1GAAMEN1KMT2A | |
| SCHEMBL2735926 | 0.68 | MAP2 (0.62) | MAP2ALDH1A1KDM4EGAAMEN1 | |
| SCHEMBL2735918 | 0.68 | ALDH1A1 (0.58) | MAP2ALDH1A1KDM4EGAAMAPT | |
| SCHEMBL18092612 | 0.68 | MEN1 (0.76) | ALDH1A1KDM4EGAAMEN1KMT2A | |
| SCHEMBL2735914 | 0.68 | MAP2 (0.59) | MAP2ALDH1A1KDM4EGAAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005040111-A2 | COMBINATORIAL LIBRARY OF 3-ARYL-1H-INDOLE-2-CARBOXYLIC ACIDS | F. HOFFMANN-LA ROCHE AG (DE) | 2005-05-06 | — | — | WO | disclosed |
| US-20050089936-A1 | Combinatorial library of 3-aryl-1H-indole-2-carboxylic acid amides | CAI JIANPING (US) | 2005-04-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050089936-A1 | Combinatorial library of 3-aryl-1H-indole-2-carboxylic acid amides | AADAC, KYNU, AANAT | MAP2 96/4885GRIN1 201/4885ALDH1A1 104/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.