Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | GFER | P55789 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | MAP2 | P11137 | 2/20 | 0.45 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.43 |
| ▸ | GPR17 | Q13304 | 3/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 4/20 | 0.40 |
| ▸ | FBP1 | P09467 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.37 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6360987 | 0.79 | MAP2 (0.46) | KDM4EALDH1A1MEN1KMT2AMAP2 | |
| SCHEMBL5738434 | 0.72 | ALDH1A1 (0.56) | ALDH1A1HPGDMEN1KMT2AHSD17B10 | |
| SCHEMBL3091494 | 0.70 | KDM4E (0.66) | KDM4EALDH1A1HPGDMEN1HTT | |
| SCHEMBL5699201 | 0.70 | ALDH1A1 (0.54) | KDM4EALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL9547957 | 0.67 | MAP2 (0.51) | KDM4EALDH1A1HPGDMAP2MCL1 | |
| SCHEMBL11300000 | 0.67 | ALDH1A1 (0.65) | KDM4EALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL19330991 | 0.66 | GPR17 (0.44) | ALDH1A1MEN1KMT2AMAP2GRIN1 | |
| SCHEMBL3107289 | 0.66 | ALDH1A1 (1.00) | KDM4EALDH1A1HPGDMEN1HTT | |
| SCHEMBL8938387 | 0.65 | NHERF1 (0.66) | KDM4EALDH1A1MEN1KMT2AMAP2 | |
| SCHEMBL29030308 | 0.65 | PDE9A (0.56) | KDM4EALDH1A1HPGDMEN1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7396940-B2 | Combinatorial library of 3-aryl-1H-indole-2-carboxylic acid | HOFFMANN-LA ROCHE INC. (US) | 2008-07-08 | — | — | US | disclosed |
| WO-2005040073-A2 | SOLID PHASE SYNTHESIS OF 3-ARYL-2- INDOLYLCARBOXYLIC ACIDS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-05-06 | — | — | WO | disclosed |
| US-20050089935-A1 | Combinatorial library of 3-aryl-1h-indole-2-carboxylic acid | CAI JIANPING (US) | 2005-04-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050089935-A1 | Combinatorial library of 3-aryl-1h-indole-2-carboxylic acid | AADAC, KYNU, DDC | KDM4E 3666/4885ALDH1A1 253/4885HPGD 1691/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.