Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PABPC1 | P11940 | 1/20 | 0.50 |
| ▸ | BACE1 | P56817 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.40 |
| ▸ | JAK2 | O60674 | 2/20 | 0.40 |
| ▸ | GPR3 | P46089 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.39 |
| ▸ | MPO | P05164 | 1/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.37 |
| ▸ | METAP2 | P50579 | 1/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | AKT1 | P31749 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.36 |
| ▸ | PLAU | P00749 | 1/20 | 0.36 |
| ▸ | NQO2 | P16083 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11518864 | 0.78 | PABPC1 (0.50) | PABPC1BACE1HTTCYP1A2CYP2C19 | |
| Hydrochloric Acid SCHEMBL11516790 | 0.76 | PABPC1 (0.48) | PABPC1BACE1HTTCYP1A2CYP2C19 | |
| SCHEMBL17075876 | 0.74 | NT5E (0.38) | PABPC1BACE1HTTCYP1A2CYP2C19 | |
| SCHEMBL16294313 | 0.74 | ALOX15 (0.39) | PABPC1BACE1HTTCYP1A2CYP2C19 | |
| SCHEMBL24252437 | 0.74 | PABPC1 (0.47) | PABPC1BACE1HTTCYP1A2CYP2C19 | |
| SCHEMBL11516837 | 0.74 | GPR3 (0.61) | PABPC1HTTCYP1A2CYP2C19GPR3 | |
| SCHEMBL38660002 | 0.74 | GPR3 (0.61) | PABPC1HTTCYP1A2CYP2C19GPR3 | |
| SCHEMBL1580032 | 0.73 | DHODH (0.40) | PABPC1HTTCYP1A2CYP2C19PIM1 | |
| SCHEMBL31372203 | 0.73 | DHODH (0.40) | PABPC1HTTCYP1A2CYP2C19PIM1 | |
| SCHEMBL10987574 | 0.73 | METAP2 (0.43) | PABPC1PDPK1JAK2ALKMETAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6951880-B2 | Aryl and heteroaryl compounds as antibacterial and antifungal agents | GENELABS TECHNOLOGIES, INC. (US) | 2005-10-04 | — | — | US | disclosed |
| EP-0831813-B1 | METHODS OF INHIBITING PNEUMOCYSTIS CARINII PNEUMONIA AND COMPOUNDS USEFUL THEREFOR | UNIV NORTH CAROLINA (US) | 2005-01-19 | — | — | EP | disclosed |
| WO-2004047724-A2 | ARYL AND HETEROARYL COMPOUNDS AS ANTIBACTERIAL AND ANTIFUNGAL AGENTS | GENELABS TECHNOLOGIES, INC (US) | 2004-06-10 | — | — | WO | disclosed |
| US-20030220340-A1 | Aryl and heteroaryl compounds as antibacterial and antifungal agents | GLAXOSMITHKLINE LLC | 2003-11-27 | — | — | US | disclosed |
| EP-0831811-B1 | CARBAZOLES FOR TREATING MICROBIAL INFECTIONS | UNIV NORTH CAROLINA (US) | 2003-11-19 | — | — | EP | disclosed |
| EP-0831811-A1 | METHODS OF TREATING MICROBIAL INFECTIONS | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1998-04-01 | — | — | EP | disclosed |
| EP-0831813-A1 | METHODS OF INHIBITING PNEUMOCYSTIS CARINII PNEUMONIA AND COMPOUNDS USEFUL THEREFOR | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1998-04-01 | — | — | EP | disclosed |
| US-5668166-A | CARBAZOLE COMPOUNDS | GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) | 1997-09-16 | — | — | US | disclosed |
| US-5668167-A | TREATMENT OF PNEUMOCYSTIS PNEUMONIA WITH CARBAZOLE DERIVATIVES | DUKE UNIVERSITY (US) | 1997-09-16 | — | — | US | disclosed |
| WO-1996040117-A1 | METHODS OF TREATING MICROBIAL INFECTIONS | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1996-12-19 | — | — | WO | disclosed |
| WO-1996040114-A1 | METHODS OF INHIBITING PNEUMOCYSTIS CARINII PNEUMONIA AND COMPOUNDS USEFUL THEREFOR | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1996-12-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030220340-A1 | Aryl and heteroaryl compounds as antibacterial and antifungal agents | AADAC, ERG28, LSS | PABPC1 4323/4885BACE1 1939/4885HTT 1426/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.