Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.41 |
| ▸ | MDM4 | O15151 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | GALK1 | P51570 | 1/20 | 0.40 |
| ▸ | CCR6 | P51684 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13662396 | 1.00 | MAPT (0.46) | MAPTSMN1; SMN2ALDH1A1KMT2ANPC1 | |
| SCHEMBL9487635 | 0.87 | MAPT (0.45) | MAPTSMN1; SMN2ALDH1A1KMT2ANPC1 | |
| SCHEMBL9488596 | 0.86 | KDM4E (0.46) | MAPTALDH1A1KMT2AMEN1RAB9A | |
| SCHEMBL629505 | 0.84 | MAPT (0.48) | MAPTSMN1; SMN2ALDH1A1KMT2ANPC1 | |
| SCHEMBL1273130 | 0.84 | MAPT (0.48) | MAPTSMN1; SMN2ALDH1A1KMT2ANPC1 | |
| SCHEMBL629506 | 0.84 | MAPT (0.48) | MAPTSMN1; SMN2ALDH1A1KMT2ANPC1 | |
| SCHEMBL187459 | 0.84 | SRC (0.46) | MAPTSMN1; SMN2ALDH1A1KMT2ANPC1 | |
| SCHEMBL5142053 | 0.84 | SRC (0.46) | MAPTSMN1; SMN2ALDH1A1KMT2ANPC1 | |
| SCHEMBL14247549 | 0.84 | SRC (0.46) | MAPTSMN1; SMN2ALDH1A1KMT2ANPC1 | |
| SCHEMBL3858960 | 0.82 | GAA (0.51) | MAPTSMN1; SMN2ALDH1A1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8981147-B2 | Diphosphine ligand and transition metal complex using the same | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2015-03-17 | — | — | US | disclosed |
| US-8981147-B2 | Diphosphine ligand and transition metal complex using the same | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2015-03-17 | — | — | US | disclosed |
| US-20140171655-A1 | DIPHOSPHINE LIGAND AND TRANSITION METAL COMPLEX USING THE SAME | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2014-06-19 | — | — | US | disclosed |
| US-20140171655-A1 | DIPHOSPHINE LIGAND AND TRANSITION METAL COMPLEX USING THE SAME | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2014-06-19 | — | — | US | disclosed |
| US-8691718-B2 | Diphosphine ligand and transition metal complex using the same | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2014-04-08 | — | — | US | disclosed |
| EP-2420507-A1 | Diphosphine ligand and transition metal complex using the same | Takeda Pharmaceutical Company Limited (JP) | 2012-02-22 | — | — | EP | disclosed |
| US-20090270635-A1 | Diphosphine Ligand and Transition Metal Complex Using the Same | TAKEDA PHARMACEUTICAL COMPANY LIMITED | 2009-10-29 | — | — | US | disclosed |
| US-20090270635-A1 | Diphosphine Ligand and Transition Metal Complex Using the Same | TAKEDA PHARMACEUTICAL COMPANY LIMITED | 2009-10-29 | — | — | US | disclosed |
| US-7589215-B2 | Bisphosphines as bidentate ligands | DEGUSSA AG (DE) | 2009-09-15 | — | — | US | disclosed |
| US-7361786-B2 | Bisphosphines as bidentate ligands | DEGUSSA AG (DE) | 2008-04-22 | — | — | US | disclosed |
| US-20070179301-A1 | BISPHOSPHINES AS BIDENTATE LIGANDS | DEGUSSA AG (DE) | 2007-08-02 | — | — | US | disclosed |
| US-20070123733-A1 | BISPHOSPHINES AS BIDENTATE LIGANDS | DEGUSSA AG (DE) | 2007-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070123733-A1 | BISPHOSPHINES AS BIDENTATE LIGANDS | BPGM, SOST, BMP2 | MAPT 4657/4885SMN1; SMN2 4786/4885ALDH1A1 2699/4885 |
| US-20070179301-A1 | BISPHOSPHINES AS BIDENTATE LIGANDS | BPGM, SOST, BMP2 | MAPT 4657/4885SMN1; SMN2 4786/4885ALDH1A1 2699/4885 |
| US-20090270635-A1 | Diphosphine Ligand and Transition Metal Complex Using the Same | MVD, C5, C1S | MAPT 4851/4885SMN1; SMN2 4797/4885ALDH1A1 1165/4885 |
| US-20140171655-A1 | DIPHOSPHINE LIGAND AND TRANSITION METAL COMPLEX USING THE SAME | MVD, C5, C1S | MAPT 4851/4885SMN1; SMN2 4797/4885ALDH1A1 1165/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.