SCHEMBL6370851

SCHEMBL6370851

Clc1cc(Cl)c(Cl)c(-c2nc(-c3ccccc3)c(-c3ccccc3)n2-n2c(-c3cc(Cl)cc(Cl)c3Cl)nc(-c3ccccc3)c2-c2ccccc2)c1

nearest known ligand 0.41

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
GAA P10253 3/20 0.40
MGAM O43451 2/20 0.40
SI P14410 2/20 0.40
MGAM2 Q2M2H8 2/20 0.40
KDM4E B2RXH2 2/20 0.38
LMNA P02545 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
AKT1 P31749 1/20 0.37
AKT2 P31751 1/20 0.37
BCHE P06276 1/20 0.37
ACHE P22303 1/20 0.37
HSD11B1 P28845 1/20 0.37
THRB P10828 1/20 0.36
PKM P14618 1/20 0.36
SCN2A Q99250 1/20 0.35
ADORA2A P29274 1/20 0.35
ADORA2B P29275 1/20 0.35
ADORA1 P30542 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7123493 0.88 GAA (0.35) GAAMGAMSIMGAM2KDM4E
SCHEMBL2689067 0.84 HSD11B1 (0.54) GAAKDM4ELMNAL3MBTL1HSD11B1
SCHEMBL31467384 0.84 HSD11B1 (0.54) GAAKDM4ELMNAL3MBTL1HSD11B1
SCHEMBL29732755 0.80 HSD11B1 (0.49) KDM4ELMNABCHEACHEHSD11B1
SCHEMBL63728 0.80 HSD11B1 (0.49) KDM4ELMNABCHEACHEHSD11B1
SCHEMBL6693283 0.76 GAA (0.33) GAAMGAMSIMGAM2KDM4E
SCHEMBL10033037 0.76 GAA (0.51) GAAMGAMSIMGAM2KDM4E
SCHEMBL4597351 0.74 BCHE (0.45) GAAKDM4ELMNAL3MBTL1BCHE
SCHEMBL2140618 0.72 CYP2A6 (0.50) HSD11B1
SCHEMBL6362343 0.71 ADORA2A (0.42) GAAMGAMSIMGAM2KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0828182-B1 Storage-stable photoimageable compositions with improved leuco dye DU PONT (US) 2003-11-19 EP claimed
US-5744280-A MONOCHROME IMAGES;IMPROVED CONTRAST E. I. DU PONT DE NEMOURS AND COMPANY (US) 1998-04-28 US claimed
EP-0889363-B1 Near IR sensitive photoimageable/photopolymerizable compositions, media, and associated processes DU PONT (US) 2005-10-05 EP disclosed
US-6861201-B2 Near IR sensitive photoimageable/photopolymerizable compositions, media, and associated processes E. I. DU PONT DE NEMOURS AND COMPANY (US) 2005-03-01 US disclosed
US-20040191681-A1 Near IR sensitive photoimageable/photopolymerizable compositions, media, and associated processes WEED GREGORY C 2004-09-30 US disclosed
EP-0828182-B1 Storage-stable photoimageable compositions with improved leuco dye DU PONT (US) 2003-11-19 EP disclosed
US-20020064728-A1 Near IR sensitive photoimageable/photopolymerizable compositions, media, and associated processes E.I. DU PONT DE NEMOURS AND COMPANY 2002-05-30 US disclosed
EP-0889363-A1 Near IR sensitive photoimageable/photopolymerizable compositions, media, and associated processes E.I. DU PONT DE NEMOURS AND COMPANY (US) 1999-01-07 EP disclosed
EP-0828182-A1 Storage-stable photoimageable compositions with improved leuco dye E.I. DU PONT DE NEMOURS AND COMPANY (US) 1998-03-11 EP disclosed