SCHEMBL6693283

SCHEMBL6693283

Clc1cc(Cl)c(Cl)c(-c2nc(-c3ccccc3)c(-c3ccccc3)n2C2(c3cc(Cl)cc(Cl)c3Cl)N=C(c3ccccc3)C(c3ccccc3)=N2)c1

nearest known ligand 0.33

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
GAA P10253 3/20 0.33
AKT1 P31749 3/20 0.33
AKT2 P31751 3/20 0.33
MGAM O43451 2/20 0.33
SI P14410 2/20 0.33
MGAM2 Q2M2H8 2/20 0.33
KDM4E B2RXH2 2/20 0.32
LMNA P02545 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
PKM P14618 1/20 0.30
BCHE P06276 1/20 0.30
ACHE P22303 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7590002 0.93 KDM4E (0.30) GAAKDM4ELMNAL3MBTL1
SCHEMBL16746551 0.83 P2RX7 (0.34) GAAAKT1AKT2KDM4ELMNA
SCHEMBL476565 0.82 HSD11B1 (0.42) GAAKDM4ELMNAL3MBTL1PKM
SCHEMBL29389827 0.82 HSD11B1 (0.42) GAAKDM4ELMNAL3MBTL1PKM
SCHEMBL307038 0.79 HSD11B1 (0.37) GAAAKT1AKT2KDM4ELMNA
SCHEMBL476551 0.79 GAA (0.38) GAAAKT1AKT2MGAMSI
SCHEMBL29359500 0.79 HSD11B1 (0.37) GAAAKT1AKT2KDM4ELMNA
SCHEMBL29749791 0.79 HSD11B1 (0.37) GAAAKT1AKT2KDM4ELMNA
SCHEMBL17133349 0.78 BCHE (0.36) GAAAKT1AKT2KDM4ELMNA
SCHEMBL6370851 0.76 GAA (0.40) GAAAKT1AKT2MGAMSI

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1376164-A1 Holographic multicolor optical elements for use in liquid crystal displays and methods of making the elements E.I. DU PONT DE NEMOURS AND COMPANY (US) 2004-01-02 EP disclosed
EP-0764282-B1 HOLOGRAPHIC MULTICOLOR OPTICAL ELEMENTS FOR USE IN LIQUID CRYSTAL DISPLAYS AND METHODS OF MAKING THE ELEMENTS DU PONT (US) 2003-11-26 EP disclosed
EP-0764283-B1 COLOR TUNED HOLOGRAPHIC OPTICAL ELEMENTS AND METHODS OF MAKING THE ELEMENTS DU PONT (US) 2002-04-24 EP disclosed
EP-0957378-A1 Holographic reflector for liquid crystal display E.I. DU PONT DE NEMOURS AND COMPANY (US) 1999-11-17 EP disclosed
EP-0764283-A1 COLOR TUNED HOLOGRAPHIC OPTICAL ELEMENTS AND METHODS OF MAKING AND USING THE ELEMENTS E.I. DU PONT DE NEMOURS AND COMPANY (US) 1997-03-26 EP disclosed
EP-0764282-A1 HOLOGRAPHIC MULTICOLOR OPTICAL ELEMENTS FOR USE IN LIQUID CRYSTAL DISPLAYS AND METHODS OF MAKING THE ELEMENTS E.I. DU PONT DE NEMOURS AND COMPANY (US) 1997-03-26 EP disclosed
US-5526145-A Color tuned holographic optical elements and methods of making and using the elements E. I. DU PONT DE NEMOURS AND COMPANY (US) 1996-06-11 US disclosed
WO-1995034834-A1 HOLOGRAPHIC MULTICOLOR OPTICAL ELEMENTS FOR USE IN LIQUID CRYSTAL DISPLAYS AND METHODS OF MAKING THE ELEMENTS E.I. DU PONT DE NEMOURS AND COMPANY (US) 1995-12-21 WO disclosed
WO-1995034833-A1 COLOR TUNED HOLOGRAPHIC OPTICAL ELEMENTS AND METHODS OF MAKING AND USING THE ELEMENTS E.I. DU PONT DE NEMOURS AND COMPANY (US) 1995-12-21 WO disclosed